Cognitive Predictors of Dementia in Elderly Community Residents

Dartigues, Jean François; Commenges, Daniel; Letenneur, Luc; Barberger‐Gateau, Pascale; Gilleron, V.; Fabrigoule, Colette; Mazaux, J.-M.; Orgogozo, J. M.; Salamon, Roger

doi:10.1159/000109668

Cited by 72 publications

(47 citation statements)

References 23 publications

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“…One was a subjective memory complaint, which was reported by 17% of future AD patients and none of those who remained healthy. Subjective memory impairment has been found to be a harbinger of further decline in subjects with no cognitive impairment at study entry [31] and has been reported to be an early and strong predictor of AD [32,53]. Similarly, 17% of AD-P and none of the NC participants reported current cardiac problems.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychological Signs of Alzheimer's Disease 8 Years Prior to Diagnosis

Schmid¹,

Taylor

Foldi

et al. 2013

JAD

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Abstract. We investigated the earliest neuropsychological changes in Alzheimer's disease (AD) by comparing the baseline performance of 29 individuals who subsequently developed AD within an average of 7.91 ± 2.70 years with 29 pairwisematched individuals who remained cognitively healthy (NC). We hypothesized that subtle, qualitative changes in cognition precede clinical AD by several years, and therefore examined subjective as well as standard quantitative measures of cognition, in addition to subjective estimates of mood and medical status. Participants were selected from the 825 members of the longitudinal BASEL study (BAsel Study on the ELderly), all of whom had been ApoE-genotyped and received comprehensive bi-annual neuropsychological assessments. Within 13 years, 29 were diagnosed with probable AD. Each individual who progressed to AD (AD-P) was pairwise matched to a NC participant based on age, education, demographic status, observation period, and, importantly, ApoE genotype. A regression analysis using the lasso technique identified which of 115 neuropsychological variables best discriminated baseline NC from baseline AD-P performance. This analysis yielded eleven neuropsychological variables that optimally discriminated the two groups (correct classification rate: 60.4%): 1) Intrusions and 2) response bias in verbal learning and memory tasks; 3) delayed figure recall; 4-6) three Wechsler Adult Intelligence Scale (WAIS) Block Design subtest variables; 7-8) number of errors and repetitions on letter fluency; and 9-11) self-report of memory problems, a feeling of sadness, and cardiac problems. These results suggest that the preclinical neuropsychological cascade to AD includes subtle but identifiable qualitative impairments in verbal and visual memory, visuospatial processing, error control, and subjective neuropsychological complaints.

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Section: Discussionmentioning

confidence: 99%

Neuropsychological Signs of Alzheimer's Disease 8 Years Prior to Diagnosis

Schmid¹,

Taylor

Foldi

et al. 2013

JAD

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“…Previous work has shown that such subjects have a lower cognitive level than those who complete the test. 38 In the context of the present study, it appeared interesting to include the total population of subjects. In order to determine the two modalities, the threshold which displayed the best separation between subjects who had ceased driving and those who continued driving, was computed using the maximum likelihood for the univariate logistic regression model.…”

Section: Discussionmentioning

confidence: 99%

Driving Cessation and Self-Reported Car Crashes in Older Drivers: The Impact of Cognitive Impairment and Dementia in a Population-Based Study

Lafont

Laumon

Helmer

et al. 2008

J Geriatr Psychiatry Neurol

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The complexity of driving activity has incited numerous developed countries to initiate evaluative procedures in the elderly, varying according to first evaluation age, frequency and screening tools. The objective of this paper is to improve the knowledge of the driving cessation process in regard to factors associated with crash involvement. Driving cessation and self-reported crashes during the past five years were analyzed with multivariate models, in a cross-sectional study including a population-based sample of 1051 drivers aged 65 years and more. Visual trouble, Parkinson disease, dementia and stroke history were associated with driving cessation. Future dementia was associated with self-reported crashes only. Attentional and executive deficits were associated with both outcomes. The detection of attentional and executive problems should be included in driving evaluation procedures in order to improve awareness of these deficits by older drivers.

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“…The Paquid Study is designed to determine the prevalence and incidence of dementias and AD in people over 3 65 years in the South-West of France. This study has carefully assessed the predictive value of psychometric performance [3] and of memory complaints either isolated or associated with objective abnormalities observed by neuropsychological examinations.…”

Section: Oooooooooooooooooooooomentioning

confidence: 99%

“…This study has carefully assessed the predictive value of psychometric performance [3] and of memory complaints either isolated or associated with objective abnormalities observed by neuropsychological examinations. The incidence of dementias varies from 0.4 per 100 person-years in normal subjects without memory complaint to 3.6 per 100 personyears in patients with memory complaint and objective impairment.…”

Section: Oooooooooooooooooooooomentioning

confidence: 99%

Detection of Cerebral Aging,an Absolute Need: Predictive Valueof Cognitive Status

Forette

Thijs

et al. 1998

Eur Neurol

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Cognitive performance is predictive of functional status, morbidity and mortality in the elderly. In the SYST-EUR study, the Vascular Dementia Project run on 3,111 subjects 60 years old and over, with isolated systolic hypertension, has shown that the cognitive status as measured by the MMSE was inversely correlated with systolic blood pressure (p < 0.001) and age (p < 0.001) and positively correlated with the level of education (p < 0.001). It is significantly lower in patients with cardiovascular complications (p = 0.0001). Moderate alcohol consumption is linked to a higher MMSE score in women (p < 0.001) but not in men. In this study, the incidence of dementia is low and significantly related to the baseline value of the MMSE score and further analysis will show the influence of the treatment of systolic hypertension with calcium antagonists as first step on this incidence.

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Cognitive Predictors of Dementia in Elderly Community Residents

Cited by 72 publications

References 23 publications

Neuropsychological Signs of Alzheimer's Disease 8 Years Prior to Diagnosis

Neuropsychological Signs of Alzheimer's Disease 8 Years Prior to Diagnosis

Driving Cessation and Self-Reported Car Crashes in Older Drivers: The Impact of Cognitive Impairment and Dementia in a Population-Based Study

Detection of Cerebral Aging,an Absolute Need: Predictive Valueof Cognitive Status

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