With the continuous increase of mass information in the process of enterprise operation, information redundancy interference poses a challenge to enterprise information decision-making. As the core of an enterprise, reliability decision-making has a direct impact on the development of human economy and the overall economic strength of a country. Therefore, this paper applies big data analysis technology to enterprise information intelligent decision-making, and builds an enterprise information intelligent decisionmaking model based on big data analysis. The key data of enterprise is mined by using the density weight Canopy to improve the K-Gmedoids algorithm. After sorting, filtering, and transforming, the big data model designed in this paper uses interactive genetic algorithms to obtain the optimal decision-making strategy of enterprise information through experimental tests, which has a significant impact on the decision-making management of the enterprise and the competitiveness of the enterprise. The interactive genetic algorithm can obtain the information decision strategy that best matches the actual decision-making problems of the enterprise through a small number of iterations.INDEX TERMS Big data, enterprise information, intelligent algorithm, reliable decision-making, interactive genetic.