Cognitive profile in prodromal dementia with Lewy bodies

Kemp, Jennifer; Philippi, Nathalie; Phillipps, Clélie; Demuynck, Catherine; Albasser, Timothée; Milch, Catherine; Schmidt-Mutter, Catherine; Crétin, Benjamin; Blanc‬, ‪Frederic

doi:10.1186/s13195-017-0242-1

Cited by 68 publications

(76 citation statements)

References 60 publications

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“…These results, along with the absence of a significant difference in the VOSP scores, might be explained by the relatively low severity of cognitive impairment in our DLB and AD patients at the group level: their mean MMSE scores were, respectively, 24.4 ± 4 and 24.1 ± 5, which usually corresponds to the limit between the prodromal and dementia stages. Indeed, according to Kemp et al [11], visuoperceptual impairments are more likely to occur at the dementia stage. As an illustration, Calderon et al [10] used the same fragmented letters task in their neuropsychological study, with DLB and AD groups whose mean MMSE scores were 20.0 and 21.4 (respectively), and they observed a significantly lower performance in the DLB patients compared to the AD and control groups.…”

Section: Discussionmentioning

confidence: 99%

“…The evaluation also included various subtests from the VOSP battery: number location, cube analysis, object decision, silhouettes, dot position. For a comprehensive description of the different neuropsychological assessments, see Kemp et al [11]. …”

Section: Methodsmentioning

confidence: 99%

“…All these results suggest that DLB patients experience visual processing deficits, affecting the perception of both objects and space. In terms of timing, a recent study [11] showed that visuospatial impairments are already present from the prodromal stage in DLB patients, while visuoperceptual impairments seem to appear later, at the dementia stage.…”

Section: Introductionmentioning

confidence: 99%

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Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Chabran

Roquet

Gounot

et al. 2018

Dement Geriatr Cogn Disord

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Aims: Limited research has been done on the functional connectivity in visuoperceptual regions in dementia with Lewy bodies (DLB) patients. This study aimed to investigate the functional connectivity differences between a task condition and an inter-task resting state condition within a visuoperceptual paradigm, in DLB patients compared with Alzheimer disease (AD) patients and healthy elderly control subjects. Methods: Twenty-six DLB, 29 AD, and 22 healthy subjects underwent a detailed clinical and neuropsychological examination along with a functional MRI during the different conditions of a visuoperceptual paradigm. Functional images were analyzed using group-level spatial independent component analysis and seed-based connectivity analyses. Results: While the DLB patients scored well and did not differ from the control and AD groups in terms of functional activity and connectivity during the task conditions, they showed decreased functional connectivity in visuoperceptual regions during the resting state condition, along with a temporal impairment of the default-mode network activity. Functional connectivity disturbances were also found within two attentional-executive networks and between these networks and visuoperceptual regions. Conclusion: We found a specific functional profile in the switching between task and resting state conditions in DLB patients. This result could help better characterize functional impairments in DLB and their contribution to several core symptoms of this pathology such as visual hallucinations and cognitive fluctuations.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Chabran

Roquet

Gounot

et al. 2018

Dement Geriatr Cogn Disord

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“…6,7 In contrast to MCI as a result of AD (MCI-AD), research on MCI as a result of Lewy bodies (MCI-LB) is limited. 4 Some cross-sectional studies suggest that the cognitive profile of MCI-LB differs from MCI-AD, with less pronounced memory impairment, 8 but lower performance in attention, 3,9 executive, 8,10 and visuospatial functions. 10,11 Other studies in MCI-LB found prominent neuropsychiatric symptoms (NPS), with frequent anxiety, apathy, and sleep disturbances.…”

mentioning

confidence: 99%

“…4 Some cross-sectional studies suggest that the cognitive profile of MCI-LB differs from MCI-AD, with less pronounced memory impairment, 8 but lower performance in attention, 3,9 executive, 8,10 and visuospatial functions. 10,11 Other studies in MCI-LB found prominent neuropsychiatric symptoms (NPS), with frequent anxiety, apathy, and sleep disturbances. 3,8 Only a few longitudinal studies on MCI-LB have been described.…”

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confidence: 99%

Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression

et al. 2020

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A BS TRACT: Objective: The objective of this study was to examine clinical characteristics, cognitive decline, and predictors for time to dementia in prodromal dementia with Lewy bodies with mild cognitive impairment (MCI-LB) compared with prodromal Alzheimer's disease (MCI-AD). Methods: We included 73 MCI-LB patients (12% female; 68 AE 6 years; Mini Mental State Examination, 27 AE 2) and 124 MCI-AD patients (48% female; 68 AE 7 years; Mini Mental State Examination, 27 AE 2) from the Amsterdam Dementia Cohort. Follow-up was available for 61 MCI-LB patients and all MCI-AD patients (3 AE 2 years). We evaluated dementia with Lewy bodies core features, neuropsychiatric symptoms, caregiver burden (Zarit caregiver burden interview), MRI, apolipoprotein genotype, and cerebrospinal fluid biomarkers (tau/Aβ 1-42 ratio). Longitudinal outcome measures included cognitive slopes (memory, attention, executive functions, and language and visuospatial functions) and time to dementia. Results: Parkinsonism was the most frequently present core feature in MCI-LB (69%). MCI-LB patients more often had neuropsychiatric symptoms and scored higher on ZARIT when compared with the MCI-AD patients. Linear mixed models showed that at baseline, MCI-LB patients performed worse on nonmemory cognitive domains, whereas memory performance was worse in MCI-AD patients. Over time, MCI-LB patients declined faster on attention, whereas MCI-AD patients declined faster on the Mini Mental State Examination and memory. Cox proportional hazards regressions showed that in the MCI-LB patients, lower attention (hazard ratio [HR] = 1.6; 95% confidence interval [CI], 1.1-2.3) and more posterior cortical atrophy (HR = 3.0; 95% CI, 1.5-5.8) predicted shorter time to dementia. In the MCI-AD patients, worse performance on memory (HR = 1.1; 95% CI, 1.0-1.2) and executive functions (HR = 1.3; 95% CI, 1.0-1.6) were independently associated with time to Alzheimer's dementia. Conclusion: MCI-LB patients have distinct neuropsychiatric and cognitive profiles with prominent decline in attention when compared with MCI-AD patients. Our results highlight the importance of early diagnosis because symptoms already have an impact in the prodromal stages.

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Individualized, cross‐validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms

Borland,

Mattson‐Carlgren,

Tideman

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONWe aimed to develop an algorithm to predict the individualized risk of future dementia using brief cognitive tests suitable for primary care.METHODSWe included 612 participants with subjective cognitive decline (SCD) or mild cognitive impairment (MCI) from the Alzheimer's Disease Neuroimaging Initiative (ADNI) study, assessed for at least 4 years or until progression to dementia. A logistic regression model, using cognitive tests as predictors and dementia progression as an outcome, stratified participants into low, intermediate, or high risk. A second model, including 1‐year cognitive test changes, was applied to the intermediate group. The models were replicated in 392 SCD/MCI participants from the BioFINDER‐1 study.RESULTSThe best two‐step model for predicting dementia incorporated Trail Making Test B (attention/executive function), Animal Fluency (verbal fluency), Mini‐Mental State Examination (global cognition), and 10‐word list recall (memory). The model's positive predictive value in ADNI was 85.8% and negative predictive value was 92.2% versus 62.5% and 95.6%, respectively, in BioFINDER‐1.DISCUSSIONThis two‐step model accurately predicts individualized dementia risk.Highlights To our knowledge, this is the first algorithm for predicting all‐cause dementia using a novel two‐step model utilizing brief cognitive tests. Applying a validated model including the Trail Making Test B, Animal Fluency, MMSE, Alzheimer's Disease Assessment Scale delayed, and immediate recall can robustly and accurately categorize individuals into low, intermediate, or high risk of dementia progression and can facilitate clinical decision‐making and personalized patient care. We created an app that is available for research and educational purposes at https://brainapps.shinyapps.io/PredictAllCauseDementia to provide an individualized risk score for dementia progression.

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Cognitive profile in prodromal dementia with Lewy bodies

Cited by 68 publications

References 60 publications

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Functional Disconnectivity during Inter-Task Resting State in Dementia with Lewy Bodies

Prodromal Dementia With Lewy Bodies: Clinical Characterization and Predictors of Progression

Individualized, cross‐validated prediction of future dementia using cognitive assessments in people with mild cognitive symptoms

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