Cognitive profiling of Parkinson disease patients with mild cognitive impairment and dementia

Biundo, Roberta; Weis, Luca; Facchini, Silvia; Formento-Dojot, Patrizia; Vallelunga, Annamaria; Pilleri, Manuela; Antonini, Angelo

doi:10.1016/j.parkreldis.2014.01.009

Cited by 89 publications

(111 citation statements)

References 26 publications

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“…We found the highest RSD% expressed by MoCA in PDD (30 %). These results corroborate previous findings that MoCA is more sensitive than the MMSE in detecting early cognitive changes in PD (Biundo et al 2014; Chou et al 2014; Dalrymple-Alford et al 2011; Hoops et al 2009). Moreover, MoCA did not show a floor effect, suggesting that this scale, as well as the MMSE, may be a valid instrument to detect dementia in PD.…”

Section: Discussionsupporting

confidence: 92%

“…Pearson’s correlation between the two scale scores at 1-year follow-up assessment was calculated. Two-way ANOVA with scale (MMSE or MOCA) and baseline cognitive severity subgroups [based on published MoCA cut-offs (Biundo et al 2014)] as predictors and rate of cognitive decline as dependent factor was carried out. Paired t test and Wilcoxon non parametric test (if normality was not assumed) were used to compare mean annual rate of change between the scales for each cognitive severity subgroup.…”

Section: Methodsmentioning

confidence: 99%

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MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study

et al. 2016

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The Mini-Mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) are the most commonly used scales to test cognitive impairment in Lewy body disease (LBD), but there is no consensus on which is best suited to assess cognition in clinical practice and most sensitive to cognitive decline. Retrospective cohort study of 265 LBD patients [Parkinson’s disease (PD) without dementia (PDnD, N = 197), PD with dementia (PDD, N = 40), and dementia with Lewy bodies (DLB, N = 28)] from an international consortium who completed both the MMSE and MoCA at baseline and 1-year follow-up (N = 153). Percentage of relative standard deviation (RSD%) at baseline was the measure of inter-individual variance, and estimation of change (Cohen’s d) over time was calculated. RSD% for the MoCA (21 %) was greater than for the MMSE (13 %) (p = 0.03) in the whole group. This difference was significant only in PDnD (11 vs. 5 %, p < 0.01), but not in PDD (30 vs. 19 %, p = 0.37) or DLB (15 vs. 14 %, p = 0.78). In contrast, the 1-year estimation of change did not differ between the two tests in any of the groups (Cohen’s effect <0.20 in each group). MMSE and MoCA are equal in measuring the rate of cognitive changes over time in LBD. However, in PDnD, the MoCA is a better measure of cognitive status as it lacks both ceiling and floor effects.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study

et al. 2016

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“…8 This is consistent with the findings of a data reduction study 24 that found cognitive testing of PDD resulted in a complex profile of domains affected and other studies that find complex profiles of poor performance in PD-MCI 25–27 By result the cumulative effect of domain-by-domain cognitive declines becomes a marker of the time in PDD-specific cognitive decline. Moreover these declines are accumulating quickly (within 1–2 years) and early changes in CDR staging (see Sum of Boxes in Table 2) need to trigger for more intensive testing.…”

Section: Discussionsupporting

confidence: 85%

“…What extent of functional impairment is needed to distinguish PD-MCI from PDD? Since criteria for PD-MCI were published a discussion has developed regarding subtest sensitivities, 24,2526 cutpoints that should be applied, 25,2726 and whether or not there exists a single domain PD-MCI. 24 The burgeoning literature suggests that extensive psychometric work will need to be conducted by many centers.…”

Section: Introductionmentioning

confidence: 99%

Onset of Mild Cognitive Impairment in Parkinson Disease

Johnson

Langford²,

Garnier‐Villarreal³

et al. 2016

Alzheimer Disease &Amp; Associated Disorders

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Objective Characterize the onset and timing of cognitive decline in PD from the first recognizable stage of cognitively symptomatic PD - mild cognitive impairment (PD-MCI) - to PD dementia (PDD). Thirty-nine participants progressed from PD to PDD and 25 remained cognitively normal. Method Bayesian estimated disease-state models described the onset of an individual’s cognitive decline across 12 subtests with a changepoint. Results Subtests measuring working memory, visual imagery, and crystalized memory changed significantly 3–5 years before their first non-zero CDR and progressively worsened from PD to PD-MCI to PDD. Crystalized memory deficits were the hallmark feature of imminent conversion of cognitive status. Episodic memory tasks were not sensitive to onset of PD-MCI. For cognitively intact PD, all 12 subtests showed modest linear decline without evidence of a changepoint. Conclusions Longitudinal disease-state models support a prodromal dementia stage (PD-MCI) marked by early declines in working memory and visuospatial processing beginning 5 years prior to clinical diagnosis of PDD. Cognitive declines in PD affect motor ability (bradykinesia), working memory and processing speed (bradyphrenia) resulting in PD-MCI where visuospatial imagery and memory retrieval deficits manifest before eventual development of overt dementia. Tests of episodic memory may not be sufficient to detect and quantify cognitive decline in PD.

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“…This finding further suggests a distinctive relation between object-related information and executive processes. Suggestively, studies with PD-MCI groups revealing naming and fluency deficits on nouns documented concomitant executive dysfunctions (Biundo et al, 2014;Caviness et al, 2007;Pfeiffer, Løkkegaard, Zoetmulder, Friberg, & Werdelin, 2014). Taken together, these data indicate that aspects of the BG may be involved in the networks supporting object-relevant knowledge (at the lexical and semantic levels) and their association with EFs, although further research is required in this regard.…”

Section: Accepted Manuscriptmentioning

confidence: 73%

Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences

Bocanegra

García

Pineda

et al. 2015

Cortex

150

129

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Cognitive profiling of Parkinson disease patients with mild cognitive impairment and dementia

Cited by 89 publications

References 26 publications

MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study

MMSE and MoCA in Parkinson’s disease and dementia with Lewy bodies: a multicenter 1-year follow-up study

Onset of Mild Cognitive Impairment in Parkinson Disease

Syntax, action verbs, action semantics, and object semantics in Parkinson's disease: Dissociability, progression, and executive influences

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