This article evaluates the efficacy, effectiveness, and clinical significance of empirically supported couple and family interventions for treating marital distress and individual adult disorders, including anxiety disorders, depression, sexual dysfunctions, alcoholism and problem drinking, and schizophrenia. In addition to consideration of different theoretical approaches to treating these disorders, different ways of including a partner or family in treatment are highlighted: (a) partner-family-assisted interventions, (b) disorder-specific partner-family interventions, and (c)more general couple-family therapy. Findings across diagnostic groups and issues involved in applying efficacy criteria to these populations are discussed.Since the 1970s, there has been a major shift in knowledge regarding the effectiveness of couple-based and family-based interventions for treating adult mental health problems. During this period, various theoretical perspectives have been articulated, specific manual-based intervention strategies have been developed, and controlled treatment outcome investigations have explored a number of specific issues of importance. The current article examines the empirical status of these couple-and family-based interventions for treating (a) marital distress and (b) adult individual diagnosable disorders. More explicitly, the primary goal of this article is to use the criteria put forth by Chambless and Hollon (1998) to evaluate the efficacy, clinical significance, and effectiveness of various interventions that involve a couple or family format.The criteria provide a unifying framework for evaluating the wide variety of psychological interventions. As we reviewed the literature on couple-and family-based interventions, we became aware that there were a number of decisions that had to be made with regard to the application of these criteria. Given that other reviewers may have interpreted and applied the Chambless and Hollon (1998) guidelines in a different manner, we begin this We thank Emily Sartor for her assistance in the preparation of this article.Correspondence concerning this article should be addressed to Donald H. Baucom, Davie Hall CB 3270, Psychology Department, University of North Carolina, Chapel Hill, North Carolina 27599-3270. Electronic mail may be sent via Internet to don_baucom@unc.edu.review by articulating how we have applied them so that the reader can better understand the bases of our conclusions.One of the major decisions that affects the empirical status of an intervention involves what investigations to include in reviewing the literature. In determining the efficacy status of a treatment, we restricted our consideration to published investigations. Attempts to obtain a comprehensive set of findings from conference presentations, unpublished dissertations, and so forth necessarily result in an incomplete and potentially skewed set of data. At times, unpublished findings are cited if mey help to make a certain point or clarify issues, but they are not considered in dete...