Cognitive status among patients with chronic obstructive pulmonary disease

Roncero, Carlos; Campuzano, Ana Isabel; Quintano, José Antonio; Molina, Jesús; Pérez, Joselín; Miravitlles, Marc

doi:10.2147/copd.s100850

Cited by 38 publications

(36 citation statements)

References 48 publications

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“…In the univariate analysis, patients with cognitive impairment had significantly worse CAT scores (25.2 [SD =6.9] versus 19.3 [SD =8.7], p <0.001). 31 It is important to point out that patients with severe cognitive impairment that prevents them from understanding and completing the questionnaires were not included in the study.…”

Section: Discussionmentioning

confidence: 99%

Depressive status explains a significant amount of the variance in COPD assessment test (CAT) scores

Miravitlles

Molina²,

Quintano³

et al. 2018

COPD

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BackgroundCOPD assessment test (CAT) is a short, easy-to-complete health status tool that has been incorporated into the multidimensional assessment of COPD in order to guide therapy; therefore, it is important to understand the factors determining CAT scores.MethodsThis is a post hoc analysis of a cross-sectional, observational study conducted in respiratory medicine departments and primary care centers in Spain with the aim of identifying the factors determining CAT scores, focusing particularly on the cognitive status measured by the Mini-Mental State Examination (MMSE) and levels of depression measured by the short Beck Depression Inventory (BDI).ResultsA total of 684 COPD patients were analyzed; 84.1% were men, the mean age of patients was 68.7 years, and the mean forced expiratory volume in 1 second (%) was 55.1%. Mean CAT score was 21.8. CAT scores correlated with the MMSE score (Pearson’s coefficient r=−0.371) and the BDI (r=0.620), both p<0.001. In the multivariate analysis, the usual COPD severity variables (age, dyspnea, lung function, and comorbidity) together with MMSE and BDI scores were significantly associated with CAT scores and explained 45% of the variability. However, a model including only MMSE and BDI scores explained up to 40% and BDI alone explained 38% of the CAT variance.ConclusionCAT scores are associated with clinical variables of severity of COPD. However, cognitive status and, in particular, the level of depression explain a larger percentage of the variance in the CAT scores than the usual COPD clinical severity variables.

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Section: Discussionmentioning

confidence: 99%

Depressive status explains a significant amount of the variance in COPD assessment test (CAT) scores

Miravitlles

Molina²,

Quintano³

et al. 2018

COPD

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“…Roncero et al showed CI in 39.4% of stable COPD patients. This study was large (N = 940), but it only assessed cognition using the Mini-Mental State Examination (MMSE) [21], which is useful as a screening tool but not as a diagnostic tool [22]. Samareh Fekri et al likewise administered the MMSE to 87 COPD patients and 60 age-and gender-matched individuals.…”

Section: Cross-sectional Studiesmentioning

confidence: 99%

“…Several studies showed an inverse relationship between CI and HRQoL as assessed with the COPD Assessment Test [21,60], the EuroQoL-5 dimensions questionnaire [21] or St George's Respiratory Questionnaire [22]. Then again, other studies did not confirm this relationship [19,62].…”

Section: Health Outcomesmentioning

confidence: 99%

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

Beers

Janssen

Gosker

et al. 2018

Expert Review of Respiratory Medicine

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Introduction: Cognitive impairment (CI) is an important but an under-recognized extra-pulmonary feature of chronic obstructive pulmonary disease (COPD). It is related to the burden of disability, worse health outcomes, and impaired self-management. Areas covered: CI includes deterioration of a wide range of cognitive functions, such as memory and various executive functions. Risk of hospitalization might be higher in patients with COPD compared to those without, with CI negatively impacting the wellbeing of patients with COPD. Disease-specific factors such as hypoxemia and inflammation, lifestyle factors such as dietary insufficiencies and lack of physical activity, and comorbidities such as obstructive sleep apnea and depression are likely to synergistically contribute to the development of CI in COPD. Tailored interventions can possibly improve CI in COPD, but this needs further investigation. Expert commentary: Further research is warranted involving the optimization of neuropsychological testing for screening and outcome assessment, longitudinal studies to investigate the development of CI in COPD over time, and randomized clinical trials to test the feasibility and efficacy of promising interventions.

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“…Cognitive impairment is multifactorial, but a history of cigarete smoking, aging and educational level are recognized as major determinants [25,26]. The origin of the cerebral dysfunction COPD -An Update in Pathogenesis and Clinical Managementin patients with COPD is still unknown, assuming the interference of several pathological relays: hypoxemia, oxidative stress, systemic inlammation, smoking, comorbidities, vascularmediated brain pathology, neurotransmiter metabolism in the central nervous system (CNS), a decrease in physical functioning, genetic and epigenetic factors.…”

Section: Copd: Fundamental Pathophysiological Mechanisms Susceptible mentioning

confidence: 99%

Neurocognitive Impairment as Systemic Effects of COPD

Oancea¹,

Tudorache²,

Tudorache³

2018

COPD - An Update in Pathogenesis and Clinical Management

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Mild cognitive impairment (MCI), also known as incipient dementia, is characterized by the decline of cognitive function greater than expected for a certain age and educational level of the individual but not severe enough to interfere with their daily activities. However, this mild cognitive impairment afects several areas: visuospatial, memory, atention and luency and it is a signiicant concern because it decreases the quality of life and treatment adherence of these patients. On the other hand, evidence suggests that individuals with Chronic obstructive pulmonary disease (COPD) also present an important risk of falls: 46% of these patients experience a fall/year, sometimes with fatal consequences. Standard clinical balance measures can predict the risk of falls in this population. Moreover, increased inlammatory biomarkers are associated with the decrease of cognitive functions and a higher risk of falls in this population. Patients with COPD have a higher balance and cognitive impairment than their healthy peers Therefore, it is important to identify, assess and understand the relevance of these comorbidities in order to characterize the full clinical spectrum of COPD and adjust prevention strategies, given the devastating consequences of these problems.

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Cognitive status among patients with chronic obstructive pulmonary disease

Cited by 38 publications

References 48 publications

Depressive status explains a significant amount of the variance in COPD assessment test (CAT) scores

Depressive status explains a significant amount of the variance in COPD assessment test (CAT) scores

Cognitive impairment in chronic obstructive pulmonary disease: disease burden, determinants and possible future interventions

Neurocognitive Impairment as Systemic Effects of COPD

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