Cognitive Therapy for Dementia Patients: A Systematic Review

Carrión, Carme; Folkvord, Frans; Anastasiadou, Dimitra; Aymerich, Marta

doi:10.1159/000490851

Cited by 63 publications

(57 citation statements)

References 66 publications

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“…CS is currently the intervention with the most robust evidence. Several studies reported an improvement of general cognitive functioning in patients with mild-to-moderate dementia after CS sessions of variable length (69–74). A recent meta-analysis showed that CS has a moderate effect size on the Mini Mental State Examination (75) and a small effect size on the Alzheimer's Disease Assessment Scale-cognitive subscale (76), which represent two commonly-used general cognitive functioning outcomes, in patients with dementia (73).…”

Section: Cognitive Interventionmentioning

confidence: 99%

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The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

Sinforiani²,

et al. 2018

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Background: Alzheimer's disease (AD) and dementia are chronic diseases with progressive deterioration of cognition, function, and behavior leading to severe disability and death. The prevalence of AD and dementia is constantly increasing because of the progressive aging of the population. These conditions represent a considerable challenge to patients, their family and caregivers, and the health system, because of the considerable need for resources allocation. There is no disease modifying intervention for AD and dementia, and the symptomatic pharmacological treatments has limited efficacy and considerable side effects. Non-pharmacological treatment (NPT), which includes a wide range of approaches and techniques, may play a role in the treatment of AD and dementia.Aim: To review, with a narrative approach, current evidence on main NPTs for AD and dementia.Methods: PubMed and the Cochrane database of systematic reviews were searched for studies written in English and published from 2000 to 2018. The bibliography of the main articles was checked to detect other relevant papers.Results: The role of NPT has been largely explored in AD and dementia. The main NPT types, which were reviewed here, include exercise and motor rehabilitation, cognitive rehabilitation, NPT for behavioral and psychological symptoms of dementia, occupational therapy, psychological therapy, complementary and alternative medicine, and new technologies, including information and communication technologies, assistive technology and domotics, virtual reality, gaming, and telemedicine. We also summarized the role of NPT to address caregivers' burden.Conclusions: Although NPT is often applied in the multidisciplinary approach to AD and dementia, supporting evidence for their use is still preliminary. Some studies showed statistically significant effect of NPT on some outcomes, but their clinical significance is uncertain. Well-designed randomized controlled trials with innovative designs are needed to explore the efficacy of NPT in AD and dementia. Further studies are required to offer robust neurobiological grounds for the effect of NPT, and to examine its cost-efficacy profile in patients with dementia.

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Section: Cognitive Interventionmentioning

confidence: 99%

“…There are still few data on the efficacy of CS on other outcomes, such as mood, behavioral symptoms, QoL, and well-being. However, preliminary results indicate that CS may improve QoL and well-being of caregivers of people with AD and dementia (69, 70, 74).…”

Section: Cognitive Interventionmentioning

confidence: 99%

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

Sinforiani²,

et al. 2018

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“…Our study showed the cognitive outcome was improved after integrative cognitive therapy, although the effect of non-pharmacological treatment on cognition has been limited and controversial in previous studies. 16 Consequently, the K-MMSE score was significantly improved after the use of the intervention. Because the practice effect of repeated cognitive tests might partly be different, we double-checked the subjective change of the cognitive function to identified caregivers using KDSQ-C.…”

Section: Discussionmentioning

confidence: 95%

“… 7 9 10 15 In addition, the effect of cognitive training has been controversial as noted in previous studies. 16 Furthermore, although most of the studies have usually reported the effect of either cognitive training, art therapy, or music therapy, few studies have reported the effect of the integrative therapy, which can be synergistically effective. We developed the integrated program comprising cognitive training, art therapy, and music therapy that is being conducted at the Centenarian's Good Memory School for several years.…”

Section: Introductionmentioning

confidence: 99%

Effect of Integrated Cognitive Intervention Therapy in Patients with Mild to Moderate Alzheimer's Disease

Jung

Lee

Kim

et al. 2020

Dement Neurocogn Disord

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Background and Purpose: The effect of the integrated program comprising cognitive training, art therapy, and music therapy has not been extensively studied in patients with Alzheimer's disease (AD). The present study investigated the effect of integrated cognitive intervention therapy on cognition, and activity of daily life (ADL), and mood in patients with mild to moderate AD. Methods: In this study, the data of 59 patients who met the National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer disease and Related Disorders Association (NINCDS-ADRDS) criteria of probable AD among those who registered at the Centenarian's Good Memory Program in Goyang from September 2014 to August 2019 were collected. We statistically analyzed the scores of Korean version of a Mini-Mental Status Examination (K-MMSE), Korean Dementia Screening Questionnaire-Cognition (KDSQ-C), Geriatric Depression Scale (GDS), Beck Anxiety Inventory (BAI), and Seoul-Instrumental Activities of Daily Living (S-IADL) of the same patients before and after the use of integrated cognitive intervention therapy. Results: K-MMSE slightly increased from 18.7±4.5 to 19.7±5.0 (p<0.001) and KDSQ-C improved from 14.5±7.6 before therapy to 12.6±7.2 after therapy (p=0.001). Mean S-IADL score improved from 17.6±7.6 before therapy to 15.7±9.5 after therapy (p<0.001). Additionally, mean GDS score before the therapy was 5.6±3.5 that improved to 4.2±3.0 after the therapy (p<0.001). Mean BAI score decreased from 8.4±10.3 before therapy to 5.9±8.4 after therapy (p=0.001). Conclusions: In conclusion, this study demonstrated the possibility that the use of an integrated cognitive therapy improved cognition, ADL, and mood (depression and anxiety) in patients with mild to moderate ADs.

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“…Psychosocial interventions are used for improving cognition or slowing the progression of cognitive impairment in ADRD patients (Duan et al, 2018). These interventions fall within a holistic view of non-pharmacological AD therapy based on the ideas of the brain's cognitive reserve and resilience that relies on keeping patients mentally and physically active (Carrión et al, 2018;Gravitz, 2018). In fact, it is widely recognized today by many that improving potentially modifiable behaviors such as involvement in social activities, doing physical exercise and keeping a healthy diet, among others, together with an active engagement in cognitive stimulating entertaining or intellectual activities, could help curtail neurodegeneration.…”

Section: Introductionmentioning

confidence: 99%

Virtual reality-based cognitive healthcare interventions: User-centered design considerations, guidelines and framework

García-Betances¹,

Mf²,

Mta³

2019

Preprint

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_______________________________________________________________________________________________________Design of computer-based non-pharmacological cognitive healthcare interventions for people afflicted by chronic neurodegenerative impairments must be soundly informed by and clearly centered on users' distinctive disabilities. In this article we present a use-oriented analysis of those cognitive interventions intended for healthcare of patients with Alzheimer's dementia and related disorders that use human-computer interaction based on virtual reality technology. The analysis identifies the most important strengths and weakness, and describes and assesses the main key opportunities and challenges inherent to the use of this type of cognitive healthcare interventions. The most critical specific usability concerns that considerably affect these interventions are described in order to be directly addressed during a user-centered design process. Significant evaluation issues that still trouble these interventions' general acceptance are also included. On the basis of this analysis, appropriate actions are recommended to help minimize accessibility and usability issues. Finally, concrete design guidelines, and a framework with its road map are proposed to direct the design process. The proposed framework's more outstanding features and functionalities are described in relation to user-centered design conceptualization, implementation and assessment. The use of a consistent usercentered design methodology, such as the one proposed here to tackle the main critical obstacles, could turn out to become the key that allows to achieve a substantial improvement of VR-based cognitive healthcare interventions effectiveness. _____________________________________________________________________________________________________ Keywords: Computerized cognitive healthcare, Virtual reality for healthcare, Non-pharmacological cognitive healthcare, Alzheimer's dementia.

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Cognitive Therapy for Dementia Patients: A Systematic Review

Cited by 63 publications

References 66 publications

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

The Multidisciplinary Approach to Alzheimer's Disease and Dementia. A Narrative Review of Non-Pharmacological Treatment

Effect of Integrated Cognitive Intervention Therapy in Patients with Mild to Moderate Alzheimer's Disease

Virtual reality-based cognitive healthcare interventions: User-centered design considerations, guidelines and framework

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