Cognitive Trajectories of Older Adults With Prediabetes and Diabetes: A Population-Based Cohort Study

Abstract

Diabetes is associated with a faster decline in perceptual speed and verbal abilities, while prediabetes is associated with lower memory performance in middle-age. However, the detrimental effects of hyperglycemia seem to not affect memory over time.

Participating in Mental, Social, and Physical Leisure Activities and Having a Rich Social Network Reduce the Incidence of Diabetes-Related Dementia in a Cohort of Swedish Older Adults

“…In support of previous findings, our results show that diabetes, especially of vascular origin, plays a role in the etiology of dementia. Furthermore, it has been suggested that diabetesrelated neurocognitive deterioration could start in the prediabetes stage (23,24). Prediabetes was associated with worse memory function in a cohort of cognitively healthy Swedish older adults (23).…”

“…Furthermore, it has been suggested that diabetesrelated neurocognitive deterioration could start in the prediabetes stage (23,24). Prediabetes was associated with worse memory function in a cohort of cognitively healthy Swedish older adults (23). Furthermore, impaired glucose metabolism, which characterizes prediabetes, has been related to smaller brain volumes, suggesting that cerebral changes may already occur in people with prediabetes (24).…”

Tracing temporal trends in dementia incidence over 25 years in central Stockholm, Sweden

“…Hypertension was defined as having blood pressure ≥140/90 mm Hg or use of antihypertensive medications (ATC codes C02‐C07 for KP and C02‐C09 for SNAC‐K) 28 . Diabetes was ascertained based on self‐report, use of antidiabetic medications (ATC code A10 for both KP and SNAC‐K), and blood glucose level 29,30 . The Stockholm patient registers were linked to both the KP and the SNAC‐K databases to ascertain the history of ischemic heart disease, atrial fibrillation, heart failure, and cerebrovascular diseases of participants at baseline.…”

Serum Insulin and Cognitive Performance in Older Adults: A Longitudinal Study

“…Insulin resistance and its related disorders such as physical inactivity, overweight and obesity are common conditions in older adults and are associated with a variety of other disorders, including cardiovascular, cerebrovascular, and peripheral vascular conditions [1][2][3][4] . Experimental studies have suggested that systemic insulin resistance or high circulating levels of insulin is accompanied by brain insulin resistance 4,5 .…”