Cognitive, visual, and motor development of 7-month-old Guadeloupean infants exposed to chlordecone

Dallaire, Renée; Muckle, Gina; Rouget, Florence; Kadhel, Philippe; Bataille, Henri; Guldner, Laurence; Seurin, Sophie; Chajès, Véronique; Monfort, Christine; Boucher, Olivier; Thomé, Jean-Pierre; Jacobson, Sandra W.; Multigner, Luc; Cordier, Sylvaine

doi:10.1016/j.envres.2012.07.006

Cited by 105 publications

(67 citation statements)

References 30 publications

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“…Monitoring contamination revealed the presence of CLD not only in soils but also in rivers, springs, drinking water, and food crop products such as tuber vegetables, cucurbits, food fishing products (shrimp, fish), and food breeding products too (ducks, hens). Consequently, contamination of the environment and of the food chain by CLD chronically exposes FWI populations, with consequences on human health such as higher prevalence of prostate cancer in FWI populations exposed to CLD (Multigner et al 2010), or delays in cognitive, visual, and motor development in young children exposed to CLD (Dallaire et al 2012).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the ecotoxicological impact of the organochlorine chlordecone on soil microbial community structure, abundance, and function

Merlin

Devers

Beguet

et al. 2015

Environ Sci Pollut Res

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The insecticide chlordecone applied for decades in banana plantations currently contaminates 20,000 ha of arable land in the French West Indies. Although the impact of various pesticides on soil microorganisms has been studied, chlordecone toxicity to the soil microbial community has never been assessed. We investigated in two different soils (sandy loam and silty loam) exposed to different concentrations of CLD (D0, control; D1 and D10, 1 and 10 times the agronomical dose) over different periods of time (3, 7, and 32 days): (i)

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Section: Introductionmentioning

confidence: 99%

Evaluation of the ecotoxicological impact of the organochlorine chlordecone on soil microbial community structure, abundance, and function

Merlin

Devers

Beguet

et al. 2015

Environ Sci Pollut Res

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“…The sanitary impact on the local population notably includes increased risk of the occurrence of prostate cancer (Multigner et al 2010), negative effects on cognitive and motor development of 7-month-old infants (Dallaire et al 2012), and increased risk of preterm birth (Kadhel et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants

Devault

Laplanche

Pascaline³

et al. 2015

Environ Sci Pollut Res

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OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible. This is an author-deposited version published in : http://oatao.univ-toulouse.fr/ Eprints ID : 15973 Abstract Chlordecone (CLD) was an organochlorine insecticide whose previous use resulted in an extensive pollution of the environment with severe health effects and social consequences. A closely related compound, 5b-hydrochlordecone (5b-hydroCLD), has been searched for and often detected in environmental matrices from the geographical area where CLD was applied. The current consensus considered that its presence was not the result of a biotic or abiotic dechlorination of CLD in these matrices but rather the consequence of its presence as impurity (synthesis by-product) in the CLD released into the environment. The aim of the present study was to determine if and to what extent degradation of CLD into 5b-hydroCLD occurred in the field. To test this hypothesis, the ratios of 5b-hydroCLD and CLD concentrations in a dataset of 810 soils collected between 2006 and 2012 in Martinique were compared to the ratios measured in 3 samples of the CLD dust commercial formulations applied in the banana fields of French West Indies (FWI) and 1 sample of the technical-grade CLD corresponding to the active ingredient used in such formulations. Soil data were processed with a hierarchical Bayesian model to account for random measurement errors and data censoring. Any pathway of CLD transformation into 5b-hydroCLD occurring over the long term in FWI soils would indeed change the ratio of 5b-hydroCLD/ CLD compared to what it was in the initially applied formulations. Results showed a significant increase of the 5b-hydroCLD/CLD ratio in the soils-25 times greater in soil than in commercial formulations-which suggested that natural CLD transformation into 5b-hydroCLD over the long term occurred in these soils. Results from this study may impact future decisions for the remediation of the polluted areas.

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“…In 2012 and 2013, respectively, Dallaire and Boucher [10,11] focused their studies on the development of infants (7-18 months old) with pre-and postnatal exposure of chlordecone mainly based on concentrations of chlordecone in cord blood and breast milk (respectively 0.06-22.9 and 0.06-6.7 g L) −1 . Conclusion of these studies suggests that exposure to environmental levels of chlordecone, OCP with well defined estrogen-like activity, is associated with persistent impairments in fine motor function during infancy.…”

Section: Introductionmentioning

confidence: 99%

Ultra-trace quantification method for chlordecone in human fluids and tissues

Bichon

Guiffard

Vénisseau

et al. 2015

Journal of Chromatography A

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Cognitive, visual, and motor development of 7-month-old Guadeloupean infants exposed to chlordecone

Cited by 105 publications

References 30 publications

Evaluation of the ecotoxicological impact of the organochlorine chlordecone on soil microbial community structure, abundance, and function

Evaluation of the ecotoxicological impact of the organochlorine chlordecone on soil microbial community structure, abundance, and function

Natural transformation of chlordecone into 5b-hydrochlordecone in French West Indies soils: statistical evidence for investigating long-term persistence of organic pollutants

Ultra-trace quantification method for chlordecone in human fluids and tissues

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