Cognutuve and Neurological Complications of Bacterial Meningitis in Adult Patients : A Hospital Based Study

El-Gindy, Eman M; Ali-Eldin, Fatima A; BAYOUMY, IMAN; Abdel-Moneim, Lamiaa; Ibrahim, Wesam A.

doi:10.12816/0017908

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“…Six percent (4 of 67) of survivors had hearing loss, 7% (5 of 67) had hemiplegia, 7% (5 of 67) had seizure disorder, and 9% (6 of 67) had optic atrophy. Another study from Egypt included patients with a mix of microbiologically confirmed bacterial meningitis and tuberculous meningitis [ 28 ]. At hospital discharge, 43% (13 of 30) of survivors with bacterial meningitis and 45% (5 of 11) with tuberculous meningitis had severe disability determined by Glasgow Outcomes Scale score.…”

Section: Resultsmentioning

confidence: 99%

Neurological Sequelae of Adult Meningitis in Africa: A Systematic Literature Review

Goldberg

Tenforde

Mitchell

et al. 2017

Open Forum Infectious Diseases

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The high human immunodeficiency virus (HIV) prevalence in sub-Saharan Africa has markedly changed the epidemiology and presentation of adult meningitis. We conducted a systematic review using PubMed, Embase, Ovid, CENTRAL, and African Index Medicus to identify studies in Africa with data on neurological outcomes in adults after meningitis. We found 22 articles meeting inclusion criteria. From 4 studies with predominately pneumococcal meningitis, a median of 19% of survivors experienced hearing loss up to 40 days. Two studies of cryptococcal meningitis evaluated 6- to 12-month outcomes; in one, 41% of survivors had global neurocognitive impairment and 20% severe impairment at 1 year, and in a second 30% of survivors had intermediate disability and 10% severe disability at 6 months. A single small study of patients with tuberculosis/HIV found marked disability in 20% (6 of 30) at 9 months. Despite the high burden of meningitis in sub-Saharan Africa, little is known about neurological outcomes of patients with HIV-associated meningitides.

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Section: Resultsmentioning

confidence: 99%