Cohen, D., S. Denbo, K. Fitzpatrick, M. Furlough, J. Grossman, C. Henry, G. Henry, R. H. Kieft, D. Marcum, J. Ruttenberg., E. Shore., A. M. Stuaffer, E. A. Waraksa, and S. Wheatley, <i>“Concerted Thought, Collaborative Action, and the Future of the Print Record.”</i>

Walker, Lizzy

doi:10.1080/01462679.2017.1412686

Cited by 1 publication

(1 citation statement)

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“…[7] CGRP can be associated with lipid metabolism, although its action in adipose tissue is still nuclear. [8] In addition, CGRP is elevated in many chronic inflammatory conditions, while PPARγ is usually decreased. [4] SP also induces production and release of pro-inflammatory cytokines, such as IL-1, IL-6 and TNFα in addition to PPARγ via neurokinin (NK) 1 receptor signalling.…”

Section: Con Clus Ionsmentioning

confidence: 99%

Evidence for neurogenic inflammation in lichen planopilaris and frontal fibrosing alopecia pathogenic mechanism

Doche

Wilcox

Ericson

et al. 2019

Experimental Dermatology

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Lichen planopilaris (LPP) and frontal fibrosing alopecia (FFA) are lymphocytic scarring alopecias affecting primarily the scalp. Although both diseases may share some clinical and histopathological features, in the last decade, FFA has become an “epidemic” particularly in Europe, North and South America with unique clinical manifestations compared to LPP, thus, raising the idea that this disease may have a different pathogenesis. Symptoms such as scalp burning, pruritus or pain are usually present in both diseases, suggesting a possible role for nerves and neuropeptides in the pathogenesis of both diseases. Based on some previous studies, neuropeptides, such as substance P (SP) and calcitonin gene‐related peptide (CGRP), have been associated with lipid metabolism and many chronic inflammatory disorders. In this study, we asked if these neuropeptides are associated with LPP and FFA scalp lesions. Alteration in the expression of SP and CGRP in affected and unaffected scalp skin from patients with both diseases was found with examination of sections using immunohistochemical techniques and confocal microscopy. We then quantitatively assessed and compared SP and CGRP expression from control, LPP and FFA scalp biopsies. Although LPP and FFA share similar histopathologic findings, opposite results were found in affected and unaffected scalp in the ELISA tests, suggesting that these diseases may have different pathogenic mechanisms. We also found presence of histopathological inflammation irrespective of evident clinical lesions, which raises the possibility that both diseases may be more generalized processes affecting the scalp.

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Section: Con Clus Ionsmentioning

confidence: 99%