The acquisition of the defining equations of Rees algebras is a natural way to study these algebras and allows certain invariants and properties to be deduced. In this paper, we consider Rees algebras of codimension 2 perfect ideals of hypersurface rings and produce a minimal generating set for their defining ideals. Then, using generic Bourbaki ideals, we study Rees algebras of modules with projective dimension one over hypersurface rings. We describe the defining ideal of such algebras and determine Cohen-Macaulayness and other invariants.