Coherent backscattering in biological media: measurement and estimation of optical properties

Yoon, Gilwon; Roy, D. N. Ghosh; Straight, Richard C.

doi:10.1364/ao.32.000580

Cited by 52 publications

(49 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,8 Because of this relationship, CBS is sensitive to the optical scattering, absorption, and polarization properties that alter the spatial reflectance profile. Employing these sensitivities, CBS has been used to study such objects as fractal aggregates, 9,10 amplifying random media, 11 cold atoms, 12 liquid crystals, 13,14 and biological tissue [15][16][17] to name a few. For use in biomedical applications, CBS offers a noninvasive tool to interrogate the optical properties of biological materials at subdiffusion length-scales where information about the scattering phase function is preserved.…”

Section: Introductionmentioning

confidence: 99%

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Radosevich¹,

Rogers²,

Capoglu³

et al. 2012

J. Biomed. Opt

View full text Add to dashboard Cite

Abstract.We present an open source electric field tracking Monte Carlo program to model backscattering in biological media containing birefringence, with computation of the coherent backscattering phenomenon as an example. These simulations enable the modeling of tissue scattering as a statistically homogeneous continuous random media under the Whittle-Matérn model, which includes the Henyey-Greenstein phase function as a special case, or as a composition of discrete spherical scatterers under Mie theory. The calculation of the amplitude scattering matrix for the above two cases as well as the implementation of birefringence using the Jones N-matrix formalism is presented. For ease of operator use and data processing, our simulation incorporates a graphical user interface written in MATLAB to interact with the underlying C code. Additionally, an increase in computational speed is achieved through implementation of message passing interface and the semi-analytical approach. Finally, we provide demonstrations of the results of our simulation for purely scattering media and scattering media containing linear birefringence.

show abstract

Section: Introductionmentioning

confidence: 99%

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Radosevich¹,

Rogers²,

Capoglu³

et al. 2012

J. Biomed. Opt

View full text Add to dashboard Cite

show abstract

“…Although the EBS phenomenon has been extensively studied in a variety of non-biological media [13][14][15][16][17][18][19][20], the investigation of EBS in biological tissue has been extremely limited [21][22][23]. A biological tissue is a weakly scattering medium ( λ >> * s l ) with * s l ranging between 0.5 to 2mm.…”

Section: Introductionmentioning

confidence: 99%

Penetration depth of low-coherence enhanced backscattering photons in the sub-diffusion regime

Subramanian¹,

Pradhan²,

Kim³

et al. 2007

Complex Dynamics and Fluctuations in Biomedical Photonics IV

View full text Add to dashboard Cite

The mechanisms of photon propagation in random media in the diffusive multiple scattering regime have been previously studied using diffusion approximation. However, similar understanding in the low-order (sub-diffusion) scattering regime is not complete due to difficulties in tracking photons that undergo very few scatterings events. Recent developments in low-coherence enhanced backscattering (LEBS) overcome these difficulties and enable probing photons that travel very short distances and undergo only a few scattering events. In LEBS, enhanced backscattering is observed under illumination with spatial coherence length sc L less than the scattering mean free path s l . In order to understand the mechanisms of photon propagation in LEBS in the sub-diffusion regime, it is imperative to develop analytical and numerical models that describe the statistical properties of photon trajectories. Here we derive the probability distribution of penetration depth of LEBS photons and report Monte Carlo numerical simulations to support our analytical results. Our results demonstrate that, surprisingly, the transport of photons that undergo low-order scattering events has only weak dependence on the optical properties of the medium ( s l and anisotropy factor g) and strong dependence on the spatial coherence length of illumination, sc L relative to those in the diffusion regime. More importantly, these low order scattering photons typically penetrate less than l s into the medium due to low spatial coherence length of illumination and their penetration depth is proportional to the one-third power of the coherence volume (i.e. 3 / 1 2 ] [ s s L l π ).

show abstract

“…However, there have been only a few reports of EBS observation in biological media and no attempt has been made to use EBS for tissue diagnosis. [19][20][21] Yoo et al 19,20 first pioneered EBS in biological tissue. Yoon et al 21 also used the EBS phenomenon to measure optical properties of tissue such as the transport mean free path.…”

Section: Introductionmentioning

confidence: 99%

Low-coherence enhanced backscattering of light: characteristics and applications for colon cancer screening

Kim¹,

Pradhan²,

Turzhitsky³

et al. 2007

SPIE Proceedings

View full text Add to dashboard Cite

The phenomenon of enhanced backscattering (EBS) of light, also known as coherent backscattering (CBS) of light, is a spectacular manifestation of self-interference effects in elastic light scattering, which gives rise to an enhanced scattered intensity in the backward direction. Although EBS has been the object of intensive investigation in non-biological media over the last two decades, there have been only a few attempts to explore EBS for tissue characterization and diagnosis. We have recently made progress in the EBS measurements of biological tissue by taking advantage of lowcoherence (or partially coherent) illumination, which is referred to as low-coherence EBS (LEBS) of light. LEBS possess novel and intriguing properties such as speckle reduction, self-averaging effect, broadening of the EBS width, depth-selectivity, double scattering, and circular polarization memory effect. After we review the current state of research on LEBS, we discuss how these characteristics apply for early cancer detection, especially in colorectal cancer (CRC), which is the second leading cause of cancer mortality in the United States. Although colonoscopy remains the gold standard for CRC screening, resource constraints and potential complications make it impractical to perform colonoscopy on the entire population at risk (age > 50). Thus, identifying patients who are most likely to benefit from colonoscopy is of paramount importance. We demonstrate that LEBS measurements in easily accessible colonoscopically normal mucosa (e.g., in the rectum of the colon) can be used for predicting the risk of CRC, and thus LEBS has the potential to serve as accurate markers of the risk of neoplasia elsewhere in the colon.

show abstract

Coherent backscattering in biological media: measurement and estimation of optical properties

Cited by 52 publications

References 16 publications

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Open source software for electric field Monte Carlo simulation of coherent backscattering in biological media containing birefringence

Penetration depth of low-coherence enhanced backscattering photons in the sub-diffusion regime

Low-coherence enhanced backscattering of light: characteristics and applications for colon cancer screening

Contact Info

Product

Resources

About