Coherent detection techniques in optical imaging of tissues

Chan, Kin Pui; Devaraj, B.; Yamada, Makoto; Inaba, Humio

doi:10.1088/0031-9155/42/5/009

Cited by 18 publications

(4 citation statements)

References 37 publications

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“…laser source, exploiting the temporal coherence of the signal to provide heterodyne detection of the interference signal together with the directional 'antenna' property provided by the spatial coherence [21]. By employing a CAT system to combine a series of single-pixel transmission measurements through different projections of the sample, images have been achieved through a range of biological and other scattering samples [58] including chicken egg, chicken bone, human teeth and opaque industrial products [59], with spatial resolution down to 50 µm (e.g. [60]).…”

Section: Imaging Using Single Channel Coherent Detection: Coherent De...mentioning

confidence: 99%

Techniques for depth-resolved imaging through turbid media including coherence-gated imaging

Dunsby

French

2003

J. Phys. D: Appl. Phys.

159

102

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This article aims to review the panoply of techniques for realising optical imaging through turbid media such as biological tissue. It begins by briefly discussing optical scattering and outlines the various approaches that have been developed to image through scattering media including spatial filtering, time-gated imaging and coherence-based techniques. The discussion includes scanning and wide-field techniques and concentrates on techniques to discriminate in favour of unscattered ballistic light although imaging with scattered light is briefly reviewed. Wide-field coherence-gated imaging techniques are discussed in some detail with particular emphasis placed on techniques to achieve real-time high-resolution three-dimensional imaging including through turbid media, providing rapid whole-field acquisition and high depth and transverse spatial resolution images.

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Section: Imaging Using Single Channel Coherent Detection: Coherent De...mentioning

confidence: 99%

Techniques for depth-resolved imaging through turbid media including coherence-gated imaging

Dunsby

French

2003

J. Phys. D: Appl. Phys.

159

102

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“…In tissue, absorption is minimized between 700 and 1300 nm, in what is known as the window of transmission. 17 Below 700 nm, absorption in blood is high and above 2500 nm absorption in water is extremely high. 11 The amount of scattering in tissue also varies with wavelength, and is minimized in the near-infrared.…”

Section: Tissue Structure and Opticsmentioning

confidence: 99%

Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography

2004

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The effectiveness of an optical coherence tomography (OCT) system depends largely on the light source chosen. Published data on the optical properties of tissues are used to quantify the exponential attenuation of broadband light on transport through tissue. The effective attenuation coefficient is taken to be the sum of the absorption and scattering coefficients. This is used to demonstrate the effect on the spectra of a wide range of published OCT sources and the change in system resolution induced, and hence to comment on the suitability of different sources for OCT. The tissues studied include skin dermis, liver, and gallbladder. Sources at higher wavelengths are shown to be capable of high-resolution OCT imaging at greater depths. Titanium:sapphire lasers would be most suited for high-resolution OCT over comparatively shallow depths into tissue. For lower-resolution applications of OCT, a semiconductor optical amplifier and ytterbium fiber sources have better powers and bandwidths than superluminescent diodes. The resolution of OCT systems is not reduced significantly with imaging depth.

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“…By extracting the NASL component through effective elimination of the dominant diffuse light component, we not only improve transillumination images but also enable computed tomography (CT) using the directly propagated light component [68,69]. Numerous techniques using coherency, polarization, and time-of-flight of the probing light have been reported for extracting the non-scattered component [70][71][72][73]. However, because NASL results from repeated forward scattering, these techniques struggle to distinguish NASL from the dominant diffuse light.…”

Section: Hardware-based Scattering Suppressionmentioning

confidence: 99%

Near-Infrared Transillumination for Macroscopic Functional Imaging of Animal Bodies

Shimizu

2023

Biology

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The classical transillumination technique has been revitalized through recent advancements in optical technology, enhancing its applicability in the realm of biomedical research. With a new perspective on near-axis scattered light, we have harnessed near-infrared (NIR) light to visualize intricate internal light-absorbing structures within animal bodies. By leveraging the principle of differentiation, we have extended the applicability of the Beer–Lambert law even in cases of scattering-dominant media, such as animal body tissues. This approach facilitates the visualization of dynamic physiological changes occurring within animal bodies, thereby enabling noninvasive, real-time imaging of macroscopic functionality in vivo. An important challenge inherent to transillumination imaging lies in the image blur caused by pronounced light scattering within body tissues. By extracting near-axis scattered components from the predominant diffusely scattered light, we have achieved cross-sectional imaging of animal bodies. Furthermore, we have introduced software-based techniques encompassing deconvolution using the point spread function and the application of deep learning principles to counteract the scattering effect. Finally, transillumination imaging has been elevated from two-dimensional to three-dimensional imaging. The effectiveness and applicability of these proposed techniques have been validated through comprehensive simulations and experiments involving human and animal subjects. As demonstrated through these studies, transillumination imaging coupled with emerging technologies offers a promising avenue for future biomedical applications.

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Coherent detection techniques in optical imaging of tissues

Cited by 18 publications

References 37 publications

Techniques for depth-resolved imaging through turbid media including coherence-gated imaging

Techniques for depth-resolved imaging through turbid media including coherence-gated imaging

Effect of target biological tissue and choice of light source on penetration depth and resolution in optical coherence tomography

Near-Infrared Transillumination for Macroscopic Functional Imaging of Animal Bodies

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