Coherent phonons and excitons in biological systems

Moskalenko, S. A.; Miglei, M. F.; Khadshi, P. I.; Pokatilov, E. P.; Kiselyova, E. S.

doi:10.1016/0375-9601(80)90612-x

Cited by 6 publications

(2 citation statements)

References 21 publications

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“…23]. The interactions between biological molecules in a polar medium (water and lipids), based on such vibrations lead to the appearance of frequency-selective long-range forces which are efficient at a distance longer than one linear dimension of the interacting macromolecules (10 2 -10 3 Ǻ ) [20,23]. The concordance in frequencies between biological molecules allowing them further selective long-distance interactions will be referred to as frequency complementarity.…”

Section: Role Of Long-range Intermolecular Interactions In Biologicalmentioning

confidence: 99%

Application Of The EIIP/ISM Bioinformatics Concept in Development of New Drugs

Veljković¹,

Veljković²,

Ballana³

et al. 2007

CMC

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The development of a new therapeutic drug is a complex, lengthy and expensive process. On average, only one out of 10,000 - 30,000 originally synthesized compounds will clear all the hurdles on the way to becoming a commercially available drug. The process of early and full preclinical discovery and clinical development for a new drug can take twelve to fifteen years to complete, and cost approximately 800 million dollars. The field of bioinformatics has become a major part of the drug discovery pipeline playing a key role in improvement and acceleration of this time and money consuming process. Here we reviewed the application of the EIIP/ISM bioinformatics concept for the development of new drugs. This approach, connecting the electron-ion interaction potential of organic molecules and their biological properties, can significantly reduce development time through (i) identification of promising lead compounds that have some activity against a disease by fast virtual screening of the large molecular libraries, (ii) refinement of selected lead compounds in order to increase their biological activity, and (iii) identification of domains of proteins and nucleotide sequences representing potential targets for therapy. Special attention is paid in this review to the application of the EIIP/ISM bioinformatics platform along with other experimental techniques (screening of a phage displayed peptide libraries, testing selected peptides and small molecules for antiviral activity in vitro) in development of HIV entry inhibitors, representing a new generation of the AIDS drugs.

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Section: Role Of Long-range Intermolecular Interactions In Biologicalmentioning

confidence: 99%

Application Of The EIIP/ISM Bioinformatics Concept in Development of New Drugs

Veljković¹,

Veljković²,

Ballana³

et al. 2007

CMC

View full text Add to dashboard Cite

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“…The optical study shows that external energy pumped into different levels converge into one similar to the energy condensation (Mesquita et al, 1993;Moskalenko et al, 1980;Rotaru et al, 1999), one could alternately model this behavior with fractured band structure (Grigor'kin and Dunaevskiĭ, 2007;Michalski and Mele, 2008;Prodan and Prodan, 2009). The temporal relaxations for three fluorescence peaks for 900 s suggest that for tubulin and microtubule, even intensity variation follows the same trend; in the absence of synchronization, it is an exponential decay process.…”

Section: Binary Condensation Of Vibration and Non-linear Ultra-fast Rmentioning

confidence: 99%

Atomic water channel controlling remarkable properties of a single brain microtubule: Correlating single protein to its supramolecular assembly

Sahu

Ghosh²,

Ghosh³

et al. 2013

Biosensors and Bioelectronics

141

129

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Microtubule nanotubes are found in every living eukaryotic cells; these are formed by reversible polymerization of the tubulin protein, and their hollow fibers are filled with uniquely arranged water molecules. Here we measure single tubulin molecule and single brain-neuron extracted microtubule nanowire with and without water channel inside to unravel their unique electronic and optical properties for the first time. We demonstrate that the energy levels of a single tubulin protein and single microtubule made of 40,000 tubulin dimers are identical unlike conventional materials. Moreover, the transmitted ac power and the transient fluorescence decay (single photon count) are independent of the microtubule length. Even more remarkable is the fact that the microtubule nanowire is more conducting than a single protein molecule that constitutes the nanowire. Microtubule's vibrational peaks condense to a single mode that controls the emergence of size independent electronic/optical properties, and automated noise alleviation, which disappear when the atomic water core is released from the inner cylinder. We have carried out several tricky state-of-the-art experiments and identified the electromagnetic resonance peaks of single microtubule reliably. The resonant vibrations established that the condensation of energy levels and periodic oscillation of unique energy fringes on the microtubule surface, emerge as the atomic water core resonantly integrates all proteins around it such that the nanotube irrespective of its size functions like a single protein molecule. Thus, a monomolecular water channel residing inside the protein-cylinder displays an unprecedented control in governing the tantalizing electronic and optical properties of microtubule.

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Potential Use of Incoherent and Coherent Light-Emitting-Diodes (LEDs) in Photomedicine

Pratesi

1985

Laser Photobiology and Photomedicine

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Coherent phonons and excitons in biological systems

Cited by 6 publications

References 21 publications

Application Of The EIIP/ISM Bioinformatics Concept in Development of New Drugs

Application Of The EIIP/ISM Bioinformatics Concept in Development of New Drugs

Atomic water channel controlling remarkable properties of a single brain microtubule: Correlating single protein to its supramolecular assembly

Potential Use of Incoherent and Coherent Light-Emitting-Diodes (LEDs) in Photomedicine

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