In 1968, Frö hlich showed that a driven set of oscillators can condense with nearly all of the supplied energy activating the vibrational mode of lowest frequency. This is a remarkable property usually compared with Bose-Einstein condensation, superconductivity, lasing, and other unique phenomena involving macroscopic quantum coherence. However, despite intense research, no unambiguous example has been documented. We determine the most likely experimental signatures of Frö hlich condensation and show that they are significant features remote from the extraordinary properties normally envisaged. Frö hlich condensates are classified into 3 types: weak condensates in which profound effects on chemical kinetics are possible, strong condensates in which an extremely large amount of energy is channeled into 1 vibrational mode, and coherent condensates in which this energy is placed in a single quantum state. Coherent condensates are shown to involve extremely large energies, to not be produced by the Wu-Austin dynamical Hamiltonian that provides the simplest depiction of Frö hlich condensates formed using mechanically supplied energy, and to be extremely fragile. They are inaccessible in a biological environment. Hence the Penrose-Hameroff orchestrated objective-reduction model and related theories for cognitive function that embody coherent Frö hlich condensation as an essential element are untenable. Weak condensates, however, may have profound effects on chemical and enzyme kinetics, and may be produced from biochemical energy or from radio frequency, microwave, or terahertz radiation. Pokorný 's observed 8.085-MHz microtubulin resonance is identified as a possible candidate, with microwave reactors (green chemistry) and terahertz medicine appearing as other feasible sources.cognitive function ͉ coherence ͉ microwave reactor ͉ orchestrated objective reduction I n 1968, Fröhlich showed how a driven collection of vibrational oscillators could achieve a highly ordered nonequilibrium state that has some properties reminiscent of Bose-Einstein condensation (1-3). Specifically, this Fröhlich condensate has nearly all of its vibrational energy concentrated in just one of its collective motions, the motion of lowest frequency. Such a condensation would have a profound influence on the dynamical properties of the system, and there has been considerable interest in finding applications in physics (4, 5), biology (6-20), and medicine (21-26). Indeed, other phenomena that give rise to similar collective properties of a system such as lasing, superconductivity, and Bose-Einstein condensation are of great importance.Fröhlich condensation has even been postulated to play a central role in cognitive function within the Penrose-Hameroff orchestrated objective reduction (Orch OR) (27, 28) and related (29, 30) proposals. These controversial (31) proposals evoke Fröhlich condensation to maintain coherent quantum dynamics within microtubules inside cells on a physiologically relevant time scale (at least microseconds), enabling them to...