A class of pseudo-hermitian quantum system with an explicit form of the positive-definite metric in the Hilbert space is presented. The general method involves a realization of the basic canonical commutation relations defining the quantum system in terms of operators those are hermitian with respect to a pre-determined positive definite metric in the Hilbert space. Appropriate combinations of these operators result in a large number of pseudo-hermitian quantum systems admitting entirely real spectra and unitary time evolution. The examples considered include simple harmonic oscillators with complex angular frequencies, Stark(Zeeman) effect with non-hermitian interaction, non-hermitian general quadratic form of N boson(fermion) operators, symmetric and asymmetric XXZ spin-chain in complex magnetic field, non-hermitian Haldane-Shastry spin-chain and LipkinMeshkov-Glick model.