The strengthening method of using hybrid fiber reinforced polymer is an effective way to increase the strengthening efficiency and lower the cost. This paper focuses on simulating the flexural behavior of reinforced concrete beam strengthened by prestressed C/GFRP (Carbon-Glass hybrid Fiber Reinforced Polymer) with different hybrid ratios and prestress levels. An elastoplastic damage constitution is used to simulate the mechanical behavior of concrete. A cohesive zone model under mixed mode is adopted to describe the debonding behavior of the FRP-concrete and concrete-steel interface. The results show good agreement with the experiment in the load-deflection curve, load-stress curve of steel, and HFRP. Furthermore, the failure mode of concrete and FRP debonding obtained from numerical simulation is the same as the test. Considering the improvement of the bending capacity, stiffness, and ductility of the strengthened beam in this paper, the best hybrid ratio of carbon to glass fiber is 1:1, and the suitable prestress level is between 30 and 50% of its ultimate strength.