Cohesive, multicomponent, dense powder flow characterization by NIR

Benedetti, C.; Abatzoglou, Nicolas; Simard, Jean-Sébastien; McDermott, Lorraine; Leonard, G. W.; Cartilier, L.

doi:10.1016/j.ijpharm.2006.12.014

Cited by 41 publications

(16 citation statements)

References 33 publications

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“…The critical diameter is the size of the smallest orifice through which powders flow. Flow rate may also be estimated by measuring the time to empty a hopper at various valve openings [7]. The tests based on avalanches characterize the flowability of a powder by measuring the time interval between avalanches in a rotating drum, where shorter times between avalanches are indicative of better flowability [8].…”

Section: Introductionmentioning

confidence: 99%

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Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding Part I: Development of the Methodology

et al. 2009

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In-line near-infrared spectroscopy (NIR) spectra were acquired and analyzed to assess the relationship between physical and chemical properties of voiding powders and their spectral changes. NIR spectra were obtained for powders voiding from a conical glass funnel while the powder flow was recorded with a digital camera. Two different approaches using in-line NIR spectra were developed to measure the flow interruptions in the powder voiding process. The first approach uses the noise in the spectra and the second is based on the baseline changes. The new method was also used to evaluate the effects of humidity on the flow of microcrystalline cellulose samples and to evaluate the effect of mixing method on the flow properties of the blends obtained. The method described may be applied to other applications that involve powder flow, and the same spectra may be used to determine drug concentration.

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Section: Introductionmentioning

confidence: 99%

“…A recently published method described the use of near-infrared spectroscopy (NIR) to measure the concentration of flowing ibuprofen powder mixtures emptied from a hopper [7]. Previous efforts have also shown that NIR spectroscopy may be used to obtain physical information from flowing blends.…”

Section: Introductionmentioning

confidence: 99%

Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding Part I: Development of the Methodology

et al. 2009

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“…The in-line measurement of powder streams is challenging, for several reasons: (i) fouling of the measurement probe frequently occurs; (ii) it is not always easy to define the actual sample size (e.g., the sampling volume of powder measured during the collection of a spectrum); and, (iii) the location of the probe should be investigated, since the probe should not block nor influence the powder stream; at the same time, it should be placed so that the moving powder stream is measured, not, e.g., only powder that is sticking to the hopper wall (i.e., when channeling occurs). Benedetti et al [10] developed a specially designed, non-contact sampling interfacing device with sapphire glass for quantitative evaluation of the API concentration in a flowing powder stream by means of near-infrared (NIR) spectroscopy. Spectra collection happened through the sapphire window and no fouling of the window was reported.…”

Section: Continuous Materials Transfer Between Unitsmentioning

confidence: 99%

Process Analytical Technology for continuous manufacturing of solid-dosage forms

Fonteyne

Vercruysse

Leersnyder

et al. 2015

TrAC Trends in Analytical Chemistry

145

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Currently, pharmaceutical production is making the switch from batch processing towards continuous processing. The quality of intermediate and end products produced by batch processes is assured by off-line testing. It is obvious that off-line tests in analytical laboratories cancel out the advantages of continuous processing, so the critical quality attributes of continuously produced pharmaceuticals need to be monitored in real time. In 2004, the US Food and Drug Administration launched the process analytical technology (PAT) concept to stimulate the pharmaceutical industry to change from off-line to real-time quality testing. This review explores the implementation of PAT tools within continuous pharmaceutical processes (i.e., blending, spray drying, roller compaction, twin-screw granulation and compression), focusing on both opportunities and challenges.

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“…77 In circumstances where post blend segregation is a high risk, on -line NIR can be used to monitor powder fl ow. 99,100 Benedetti and associates developed an on -line, real -time NIR method to characterize the homogeneity of fl owing powder mixtures while being discharged from a hopper prior to compression or encapsulation. A PLS model was used to predict API concentration from fl owing blend powder spectra.…”

Section: Powder Fl Owmentioning

confidence: 99%

On‐Line PAT Applications of Spectroscopy in the Pharmaceutical Industry

Smith‐Goettler¹

2010

Process Analytical Technology

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Cohesive, multicomponent, dense powder flow characterization by NIR

Cited by 41 publications

References 33 publications

Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding Part I: Development of the Methodology

Near-infrared Spectroscopy for the In-line Characterization of Powder Voiding Part I: Development of the Methodology

Process Analytical Technology for continuous manufacturing of solid-dosage forms

On‐Line PAT Applications of Spectroscopy in the Pharmaceutical Industry

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