In this article, several cohomology spaces associated to the arithmetic groups SL 3 (Z) and GL 3 (Z) with coefficients in any highest weight representation M λ have been computed, where λ denotes their highest weight. Consequently, we obtain detailed information of their Eisenstein cohomology with coefficients in M λ . When M λ is not self dual, the Eisenstein cohomology coincides with the cohomology of the underlying arithmetic group with coefficients in M λ . In particular, for such a large class of representations we can explicitly describe the cohomology of these two arithmetic groups. We accomplish this by studying the cohomology of the boundary of the Borel-Serre compactification and their Euler characteristic with coefficients in M λ . At the end, we employ our study to discuss the existence of ghost classes.
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