Let (C, E, s) be an extriangulated category with a proper class ξ of E-triangles.In this paper, we study complete cohomology of objects in (C, E, s) by applying ξ-projective resolutions and ξ-injective coresolutions constructed in (C, E, s). Vanishing of complete cohomology detects objects with finite ξ-projective dimension and finite ξ-injective dimension. As a consequence, we obtain some criteria for the validity of the Wakamatsu Tilting Conjecture and give a necessary and sufficient condition for a virtually Gorenstein algebra to be Gorenstein. Moreover, we give a general technique for computing complete cohomology of objects with finite ξ-Gprojective dimension. As an application, the relationships between ξ-projective dimensions and ξ-Gprojective dimensions for objects in (C, E, s) are given.