Cohort event monitoring of patients treated for uncomplicated malaria with artemisinin-based combination therapies in selected hospitals and community pharmacies in Nigeria

Bassi, PU; Osakwe, AI; Suku, Comfort; Kalat, M; Elagbaje, Cassandra; Isah, Ambrose O.; Ayinbuomwan, Stephen A; Wammanda, RD; Bob-Okon, II; Ambe, J P; Mava, Y; Adesina, AO; Ugochukwu, Chika G.; Nyong, EE; Ogunleye, OO; Onuoha, F; Jalo, I; Adegoke, VO; Balogun, Sulayman Tunde; Ntadom, Godwin; Ejiekpe, FN; Tahir, R; Dabit, K; Amodu, AA; Nwaosu, S; Habib, AT

doi:10.4103/1117-1936.196246

Cited by 7 publications

(6 citation statements)

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“…but with a higher prevalence of anaemia (84.1%). It differed from the report by Bassi et al (2016) in Jos, who reported prevalence of anaemia in pregnant women to be 65.3% in first trimester. Similarly, Bankole et al (2012) in Benin city reported a higher prevalence of 78.9% malarial infection and 46.2% anaemia among the pregnant women.…”

Section: Discussioncontrasting

confidence: 93%

Prevalence of Anaemia (Reduced Packed Cell Volume) Among Pregnant Women Attending Antenatal Clinics in Katsina Metropolis

Dibal,

Bashir,

Emere

2023

FJS

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Anaemia during pregnancy is still a major health problem in malaria endemic countries with clinical consequences including death of both mother and child. Moderate or severe anaemia during pregnancy may be associated with heavy parasitic infestation. This study investigated prevalence of anaemia among pregnant women attending antenatal clinics in Katsina metropolis, Katsina state. A cross-sectional study was carried out among 250 pregnant women attending four different public health centers in Katsina metropolis. Blood samples were obtained to determine their PCV. The PCV count was determined using hematocrit reader. The overall prevalence of anaemia for the all hospital was 110 (44.0%). The highest prevalence of anaemia 54 (84.38%) was recorded among pregnant women attending Turai Yar’adua Maternal and Children Hospital. The least prevalence of anaemia 14 (28.58%) was recorded among pregnant women attending PHC Kofar Marusa. A high prevalence of anaemia among pregnant women in this study was an indication of possible anaemia within the study area. This study advocates the need for pregnant women to undergo routine haemoglobin estimation and early malaria prophylaxis considering the deleterious effects of anaemia on them and their foetus.

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Section: Discussioncontrasting

confidence: 93%

Prevalence of Anaemia (Reduced Packed Cell Volume) Among Pregnant Women Attending Antenatal Clinics in Katsina Metropolis

Dibal,

Bashir,

Emere

2023

FJS

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“…This could be partly due to the perceived general safety of HMs (11) and unawareness of the inclusion of HMs among the products covered by PVG (unpublished data). Similarly, records have shown that most of the active surveillance of safety monitoring conducted in 2014 -2018 focused on antimalarial drugs (23,24). Thus, the NPC needs to improve on her activities such as (i) active surveillance of efficacy and safety of HMs, (ii) causality assessment of HMs-related reports, and (iii) awareness campaign and education of the public and relevant professionals on the need to report adverse reactions due to HMs.…”

Section: Discussionmentioning

confidence: 99%

“…In Nigeria, the National Pharmacovigilance Centre (NPC), a unit of the National Food and Drug Administration and Control (NAFDAC) is statutorily responsible for PVG activities (22). NPC has conducted several safety monitoring activities including cohort event monitoring of drugs (23), however, the efforts on HMs are considered inadequate. Similarly, few studies have evaluated the PVG system in Nigeria using the WHO indicators with a focus on conventional medicines (24).…”

Section: Introductionmentioning

confidence: 99%

Safety monitoring of herbal medicines in Nigeria: worrying state of pharmacovigilance system based on WHO core pharmacovigilance indicators

Balogun

Okon

Akanmu

et al. 2021

J Herbmed Pharmacol

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Introduction: Herbal medicines (HMs) have shown therapeutic and toxicological potentials. Thus, the WHO expanded the pharmacovigilance (PVG) scope to include HMs. This study appraised the state of PVG system in Nigeria for the safety monitoring of HMs using WHO core PVG indicators. Methods: Between January and June 2019, 39 PVG experts were requested to independently appraise the PVG system in Nigeria for safety monitoring of HMs using WHO PVG core structural (CSIs), process (CPIs) and outcome (COIs) indicators. The 27 indicators (CSIs = 10, CPIs = 9 and COIs = 8) were scored 3, 2, 1 and 0 for adequate, fairly adequate, inadequate and uncertain states, respectively. CSIs index (CSII) was determined by dividing the summation of CSIs mean score by total obtainable score (30) and expressed in percentage. This was applied to CPIs and COIs to obtain CPIs index (CPII) and COIs index (COII), respectively. Results: The mean ± standard deviation (SD) of participants’ age was 43.6 ± 10.3 years with mean ± SD work experience of 15.3 ± 9.3 years. Majority had doctoral degree (35.9%; 14/39; P >0.05) and were medical doctors (28.2%; 11/39; P > 0.05). Twelve of the 27 indicators scored at least 2.0 and CSIs, CPIs, and COIs accounted for 75.0% (9/12), 0.0% (0/12) and 25.0% (3/12), respectively (P < 0.05). The total mean score was 27.3 ± 0.2 for CSIs as against 8.0 ± 0.3 for CPIs and 11.2 ± 0.4 for COIs (P < 0.05). The CSII, CPII and COII were 91.0%; 29.6% and 46.7%, respectively (P < 0.05). Conclusion: Most of the structural elements are in place for safety monitoring of HMs in Nigeria. However, the process and outcome of PVG indicate an inadequate state. Thus, deliberate efforts are required to ensure the realization of PVG objectives.

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“…The initial safety concerns observed by health care practitioners within the country with the introduction of the ACTs prompted the Federal Ministry of Health (FMOH) to carry out a pilot programme on Cohort Event Monitoring (CEM) across the six geopolitical zones of the country in 2009 (7). This was subsequently scaled up to a cohort of 10,000 patients in 2012 (8).…”

Section: Introductionmentioning

confidence: 99%

Artemisinin-based antimalarial combination therapy amongst healthcare professionals in a tertiary facility in south-south Nigeria: preferences, tolerability, and cost considerations

Ayinbuomwan¹,

Opadeyi²,

Isah³

2022

REJHS

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Background: Nigeria adopted the Artemisinin-Based Combination Therapy (ACT) as the mainstay of treating uncomplicated malaria in February 2005. However, the individual preferences for the use of these medicines by health care professionals (HCP) as distinct from their observed prescribing practices is largely unknown. This study determined the preferences, tolerability and cost of the ACTs among HCPin Benin-City.Methods: This descriptive cross-sectional study was conducted in the University of Benin Teaching Hospital, Benin-City, Nigeria. Consenting HCPs were recruited consecutively for the study. Semistructured questionnaires were administered to doctors, nurses and pharmacists in the hospital. Information obtained included demographics, treatment of malaria in the previous year, antimalarial medication preferences and tolerability as well as cost of ACT.Results: A total of 556 HCPs, 295 doctors (54.1%), nurses 200 (36.0%), pharmacists 61(11.0%) completed the questionnaire. In the previous year, 224 (75.9%) doctors, 153 (79.1%) nurses, and 48 (70.5%) pharmacists had treatment for malaria and self-medication was highest among doctors (228, 77.3%). Artemether-Lumenfantrine was the most preferred antimalarial used, 294 (52.8%); however, 1.6% used chloroquine sulphate and ACTs were perceived to be ineffective by 25.4%. Adverse effects were experienced by 167 (29.1%) resulting in 50 (9.0%) discontinuing their medication. Between 500 and 1500 Naira (~US$1-4) was expended on ACT by 66.3% of the staff, while 21.4% were concerned about the high cost of medications.Conclusion: This study highlights the use and preferences, self-medication practices, perceived lack of effectiveness and high cost of ACTs from a HCP perspective. There is an urgent need to address these concerns in view of adverse consequences as well as the likely possibility of its the impact on prescribingpractices.

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Cohort event monitoring of patients treated for uncomplicated malaria with artemisinin-based combination therapies in selected hospitals and community pharmacies in Nigeria

Abstract: Various types of AEs were seen and documented during the CEM programme. The findings suggested that the AA/AL monitored during this programme was generally safe and remarkably well tolerated among the Nigerian populations.

Cited by 7 publications

References 1 publication

Prevalence of Anaemia (Reduced Packed Cell Volume) Among Pregnant Women Attending Antenatal Clinics in Katsina Metropolis

Prevalence of Anaemia (Reduced Packed Cell Volume) Among Pregnant Women Attending Antenatal Clinics in Katsina Metropolis

Safety monitoring of herbal medicines in Nigeria: worrying state of pharmacovigilance system based on WHO core pharmacovigilance indicators

Artemisinin-based antimalarial combination therapy amongst healthcare professionals in a tertiary facility in south-south Nigeria: preferences, tolerability, and cost considerations

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