Cohort of Patients Referred for Brugada Syndrome Investigation in an
            Electrophysiology Service - 19-Year Registry

Neto, Stefan Warpechowski; Leiria, Tiago Luiz Luz; Ley, Laura; Ley, Antonio Lessa Gaudie; Dutra, Luiza Zwan; Pires, Leonardo Martins; Kruse, Marcelo Lapa; Lima, Gustavo Glotz de

doi:10.5935/abc.20180094

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…The mean age and gender was not significantly different between inducible and noninducible patients. In line with our results, no considerable differences were found between inducible and noninducible patients 26 …”

Section: Discussionsupporting

confidence: 92%

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Brugada syndrome in Iran: Insights from a 12‐year longitudinal study

Haghjoo,

Askarinejad,

Madadi

et al. 2024

Cardiovasc electrophysiol

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BackgroundBrugada syndrome (BrS) is characterized by ST‐segment elevation in the right precordial leads, which is not explained by ischemia, electrolyte disturbances, or obvious structural heart disease.AimIn present study, we aim to evaluate presentation, long‐term outcome, genetic findings, and therapeutic interventions in patients with BrS.MethodsBetween September 2001 and June 2022, all consecutive patients with diagnosis of BrS were enrolled in the present study. All patients gave written informed consent for the procedure, and the local ethical committee approved the study.ResultsOf the 76 cases, 79% were proband and 21% were detected during screening after diagnosis of BrS in a family member. Thirty‐three (43%) patients had a typical spontaneous electrocardiogram (ECG) pattern. Thirty percent of the patients were symptomatic; symptomatic patients were more likely to have spontaneous type 1 Brugada ECG pattern in their ECGs (p = .01), longer PR interval (p = .03), and SCN5A mutation (p = .01) than asymptomatic patients. The mean PR interval was considerably longer in men than women (p = .034). SCN5A mutation was found in 9 out of 50 (18%) studied patients. Fifteen percent received appropriate implantable cardioverter‐defibrillator (ICD) therapy and inappropriate ICD interventions were observed in 17%. Presentation with aborted SCD or arrhythmic syncope was the only predictor of adverse outcome in follow‐up (odds ratio: 3.1, 95% confidence interval: 0.7–19.6, p = .001).ConclusionsSymptomatic patients with BrS are more likely to present with spontaneous type 1 Brugada ECG pattern, longer PR interval, and pathogenic mutation in SCN5A gene. Appropriate ICD interventions are more likely in symptomatic patients and those with SCN5A mutation.

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Section: Discussionsupporting

confidence: 92%

“…In line with our results, no considerable differences were found between inducible and noninducible patients. 26…”

Section: Electrophysiology Studymentioning

confidence: 99%

Brugada syndrome in Iran: Insights from a 12‐year longitudinal study

Haghjoo,

Askarinejad,

Madadi

et al. 2024

Cardiovasc electrophysiol

View full text Add to dashboard Cite

show abstract

“…Além disso, SBr acomete, principalmente, os pacientes da meia-idade, na maioria dos casos o diagnóstico ocorre aos 45 anos, sendo oito vezes mais prevalente nos homens do que nas mulheres (proporção de 8-9:1). [3][4][5] Foi descoberta em 1992 pelos irmãos Pedro e Josep Brugada, os quais publicaram uma série de relatos de oito pacientes com morte súbita abortada, ressuscitados com sucesso da fibrilação ventricular (FV). Esses pacientes apresentavam características semelhantes como bloqueio de ramo direito, elevação persistente do segmento ST e, morte súbita cardíaca.…”

Section: Introductionunclassified

Síndrome de Brugada: aspectos fisiopatológicos e práticas atuais no diagnóstico clínico e tratamento

Santos,

De Carvalho,

Rocha

et al. 2023

Braz. J. Hea. Rev.

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Síndrome de Brugada (SBr) é uma condição arrítmica não estrutural caracterizada por anormalidades eletrocardiográficas do segmento ST nas derivações precordiais direita, associada a risco elevado de arritmias ventriculares e morte súbita. O cardioversor desfibrilador implantável é a melhor conduta para prevenção desses eventos fatais, sendo a síndrome mais prevalente em homens do que em mulheres (proporção de 8-9:1). Identificar o quantitativo de artigos publicados que abordam sobre os aspectos fisiopatológicos, os métodos atuais no diagnóstico e como é realizado o tratamento dessa doença. Pesquisa desenvolvida através da revisão sistemática da literatura do quantitativo de estudo publicado sobre a fisiologia, fisiopatologia, diagnóstico e tratamento dessa síndrome. O referencial teórico foi baseado na análise de artigos publicados nos últimos cinco anos nas bases científicas Scielo, Medline e Lilacs, foram encontrados 402 artigos, sendo 31 selecionados para a escrita deste trabalho. Os critérios de exclusão são textos publicados antes de 2015 e artigos em que SBr não é o principal assunto abordado. Foram encontradas 31 referências que abordam sobre os temas propostos, sendo 29 artigos publicados nos últimos cinco anos e dois livros publicados em 2011 e 2013. Recomenda-se a realização de mais estudos sobre a SBr com objetivo de promover debates e difundir conhecimento sobre essa síndrome.

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Cohort of Patients Referred for Brugada Syndrome Investigation in an Electrophysiology Service - 19-Year Registry

Cited by 2 publications

References 21 publications

Brugada syndrome in Iran: Insights from a 12‐year longitudinal study

Brugada syndrome in Iran: Insights from a 12‐year longitudinal study

Síndrome de Brugada: aspectos fisiopatológicos e práticas atuais no diagnóstico clínico e tratamento

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