Cohort Profile: Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohorts

Dabis, François; Balestre, Eric; Braitstein, Paula; Miotti, Paolo; Brinkhof, W. G.Martin; Schneider, Martin; Schechter, Mauro; Laurent, Christian; Boulle, Andrew; Kabugo, Charles; Capkun, Gorana; Seyler, Catherine; McIntyre, James; Sprinz, Eduardo; Bansgberg, David; Borght, S van der; Egger, Matthias; Anglaret, Xavier; Hosseinipour, Mina C.; Kumarasamy, Kumar; Sidle, John E.; Filali, Kamal Marhoum El; Wood, Robin; Dickinson, Diana; Ndir, Adama; Ekong, Ernest; Borght, Stefaan Van Der; Khongphatthanayothin, Mana; Bangsberg, David R.; Ba-Gomis, Franck Olivie; Sylla, Aliou; Meilo, Henriette; Miller, Steven; Mead, Tim P.

doi:10.1093/ije/dyi164

Cited by 68 publications

(20 citation statements)

References 19 publications

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“…This is traditionally attributed to incomplete adherence, and the psychosocial instability that comes with drug-seeking behavior [16, 17]. International treatment cohorts which have documented the efforts of ART programs in low income countries (ART-LINC) have excluded resource-limited countries with higher rates of IDU [5, 6]. Amongst developing nations, China and Russia have been estimated to have the highest rates of IDU [18].…”

Section: Discussionmentioning

confidence: 99%

“…The success of ART programs has been documented in resource-limited settings throughout the world [4]. However, cohorts examining the effectiveness of ART programs in low-income countries traditionally consist of countries with a low prevalence of IDU, the majority of which are in Africa [5, 6]. Thus, there is less information regarding ART scale-up efforts in resource-limited settings with a high burden of comorbid IDU.…”

Section: Introductionmentioning

confidence: 99%

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HIV Suppression among Patients on Treatment in Vietnam: A Review of HIV Viral Load Testing in a Public Urban Clinic in Ho Chi Minh City

Trinh

Montague

Flanigan

et al. 2011

AIDS Research and Treatment

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Background. There are few reports of HIV viral load (VL) testing among patients on ART in Vietnam. Methods. From a public clinic in Ho Chi Minh City (HCMC), we reviewed cases of VL measurements from adults on ART. Results. We identified 228 cases. Median age was 30 years (27–34), 85% were male, and 77% had a history of IDU. The mean ART duration was 26 months (95% CI 25–27); d4T/3TC/NVP was the most common regimen. Viral suppression was seen in 160/228 (70%). Viremia (>1000 copies/mL) was associated with prior ART exposure (OR 5.68, P < .0001) and immunologic failure (OR 4.69, P = .0001). Targeted testing accounted for 13% of cases, only half of which yielded viremia. Conclusion. We demonstrate a high HIV suppression rate among patients on ART in HCMC, Vietnam. In this setting, routine testing detects viremia missed by targeted testing.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

HIV Suppression among Patients on Treatment in Vietnam: A Review of HIV Viral Load Testing in a Public Urban Clinic in Ho Chi Minh City

Trinh

Montague

Flanigan

et al. 2011

AIDS Research and Treatment

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“…With the rapid scaling up of ART, mortality has been widely explored in HIV-1 infected patients receiving ART (31–33) but not so much in the context of HIV-2 infection. Indeed, some papers have described immune recovery and viral suppression (34*,35), but just a few of them described mortality and survival patterns of cohorts so far (36–39) (Table 2).…”

Section: Mortality Estimates In People Living With Hiv-2mentioning

confidence: 99%

Mortality and survival patterns of people living with HIV-2

Tchounga

Ekouévi

Balestre

et al. 2016

Current Opinion in HIV and AIDS

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Purpose of review People living with HIV-2 infected usually initiate antiretroviral therapy (ART) at an advanced period in the course of their infection after a long asymptomatic period characterized by high CD4 cell count and thus at a relatively advanced age. In the new international context of early and universal ART initiation, the aim was to review survival patterns among HIV-2 infected patients, either on ART or not. Recent findings Very few reports were published on mortality in people living with HIV-2 during the last five years. People living with HIV-2 experience high mortality rates although lower than people living with HIV-1 before ART initiation. They seem to survive longer regardless of the conditions of ART use. Mortality is associated with late presentation, male gender, CD4 count <500 cell/μl, high plasma viral load, hemoglobin rate <8 g/dl) and body mass index < 18 Kg/m2. Summary People living with HIV-2 initiate ART later than HIV-1 and HIV duals, resulting in higher disease progression and mortality rate. The clinical management of HIV-2 infected patients should now include early diagnosis and treatment initiation as per international guidelines. Further research needs to explore the “what to start” question and document specific causes of death in people living with HIV-2 and enrolled in care in Africa.

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“…We do not suspect that the error rates observed in our cohort are substantially higher than those that would be seen if source-to-database audits were performed in other multi-center HIV cohorts. Indeed, several of our sites have participated in other multi-site cohorts such as ART-LINC, TCHARI, and CHIAC [14], [23], [24]. We do not claim that the findings of other multi-center observational HIV cohorts are erroneous, but it is difficult to interpret study validity without a formal assessment of data quality.…”

Section: Discussionmentioning

confidence: 96%

Measuring the Quality of Observational Study Data in an International HIV Research Network

et al. 2012

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Observational studies of health conditions and outcomes often combine clinical care data from many sites without explicitly assessing the accuracy and completeness of these data. In order to improve the quality of data in an international multi-site observational cohort of HIV-infected patients, the authors conducted on-site, Good Clinical Practice-based audits of the clinical care datasets submitted by participating HIV clinics. Discrepancies between data submitted for research and data in the clinical records were categorized using the audit codes published by the European Organization for the Research and Treatment of Cancer. Five of seven sites had error rates >10% in key study variables, notably laboratory data, weight measurements, and antiretroviral medications. All sites had significant discrepancies in medication start and stop dates. Clinical care data, particularly antiretroviral regimens and associated dates, are prone to substantial error. Verifying data against source documents through audits will improve the quality of databases and research and can be a technique for retraining staff responsible for clinical data collection. The authors recommend that all participants in observational cohorts use data audits to assess and improve the quality of data and to guide future data collection and abstraction efforts at the point of care.

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Cohort Profile: Antiretroviral Therapy in Lower Income Countries (ART-LINC): international collaboration of treatment cohorts

Cited by 68 publications

References 19 publications

HIV Suppression among Patients on Treatment in Vietnam: A Review of HIV Viral Load Testing in a Public Urban Clinic in Ho Chi Minh City

HIV Suppression among Patients on Treatment in Vietnam: A Review of HIV Viral Load Testing in a Public Urban Clinic in Ho Chi Minh City

Mortality and survival patterns of people living with HIV-2

Measuring the Quality of Observational Study Data in an International HIV Research Network

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