2022
DOI: 10.1136/bmjopen-2022-062187
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Cohort profile:Stop the Spread Ottawa (SSO)a community-based prospective cohort study on antibody responses, antibody neutralisation efficiency and cellular immunity to SARS-CoV-2 infection and vaccination

Abstract: PurposeTo investigate the robustness and longevity of SARS-CoV-2 immune responses conferred by natural infection and vaccination among priority populations such as immunocompromised individuals and people with post-acute sequelae of COVID-19 in a prospective cohort study (Stop the Spread Ottawa—SSO) in adults living in the Ottawa region. In this paper, we describe the study design, ongoing data collection and baseline characteristics of participants.ParticipantsSince October 2020, participants who tested posit… Show more

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Cited by 13 publications
(22 citation statements)
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“…The current multi-center prospective observational cohort study (CTN 328) of PWH recruited from sites in Montreal, Toronto, Ottawa, and Vancouver, with the plan to compare the COVID-19 immune response produced by vaccination, with that of HIV-negative controls, who had data collected at the same time points, in a parallel cohort study (Stop the Spread Ottawa-SSO) [ 13 ]. The CTN328 protocol was previously published [ 9 ], and later amended to accommodate 3rd and 4th doses/boosters.…”
Section: Study Design and Methodsmentioning
confidence: 99%
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“…The current multi-center prospective observational cohort study (CTN 328) of PWH recruited from sites in Montreal, Toronto, Ottawa, and Vancouver, with the plan to compare the COVID-19 immune response produced by vaccination, with that of HIV-negative controls, who had data collected at the same time points, in a parallel cohort study (Stop the Spread Ottawa-SSO) [ 13 ]. The CTN328 protocol was previously published [ 9 ], and later amended to accommodate 3rd and 4th doses/boosters.…”
Section: Study Design and Methodsmentioning
confidence: 99%
“…A subset of immunocompetent SSO participants was used as HIV-negative controls and was included if they had undergone parallel blood collection in relation to vaccination time. A detailed description of this cohort was recently published [ 13 ].…”
Section: Study Design and Methodsmentioning
confidence: 99%
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“…Cryopreserved peripheral blood mononuclear cells (PBMCs) from PLWH were obtained via the multi-centre prospective observational cohort study (CTN328) with recruitment sites located at the McGill University Health Center (Montreal, QC, Canada), University Health Network (Toronto, ON, Canada), the Ottawa Hospital (Ottawa, ON, Canada), and the British Columbia Centre for Excellence in HIV/AIDS (Vancouver, BC, Canada). Specimens from age-matched seronegative individuals were obtained from the Stop the Spread Ottawa (SSO) cohort [ 12 ]. Details regarding participant recruitment and inclusion/exclusion criteria for these cohorts have been previously described [ 8 , 12 ] and are outlined in Materials S1 .…”
Section: Methodsmentioning
confidence: 99%
“…Specimens from age-matched seronegative individuals were obtained from the Stop the Spread Ottawa (SSO) cohort [ 12 ]. Details regarding participant recruitment and inclusion/exclusion criteria for these cohorts have been previously described [ 8 , 12 ] and are outlined in Materials S1 . For the current study, participants were excluded if they had received any blood product or immunoglobulin preparation within 1 month of vaccination or if they experienced a SARS-CoV-2 infection (according to nucleic acid-, antigen-, or serology-based tests) during follow-up.…”
Section: Methodsmentioning
confidence: 99%