Cohort profile: COpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO)

Abstract

PurposeMigraine has consistently been connected with rosacea. Commonalities in epidemiology, trigger factors and associated neuropeptides support shared aetiology and pathophysiological pathways, though underlying mechanisms remain unclear. We established two cohorts of patients diagnosed with either migraine and/or rosacea. All patients were phenotyped in regard to migraine and rosacea. In this article, we describe the baseline parameters of the cohorts. In the future, we expect that these cohorts will help uncover potential disease overlaps and allow for prolonged follow-up through national Danish health registers.ParticipantsCOpenhagen ROsacea COhort (COROCO) and COpenhagen MIgraine COhort (COMICO) are prospective cohorts based in the Capital region of Denmark. Participants for COROCO were recruited primarily through two tertiary dermatology clinics in Copenhagen, Denmark and patients for COMICO were recruited through a tertiary neurology clinic in Copenhagen, Denmark.Findings to dateCOROCO: 67.7% women (median age 51 years (interquartile range (IQR) 43.0–61.0)). Family history of migraine: 44.3%. Family history of rosacea: 45%. There were 13% who currently smoked, and 36.6% were former smokers. Regular intake of alcohol was present in 79.3% (median 4 items/week (IQR 1.0–9.0)). Median body mass index (BMI): 25.7 (IQR 23.1–29.0). Median Dermatology Life Quality Index (DLQI): 2 (IQR 1–5).COMICO: 88.5% women (median age 41 years (IQR 29.5–51.0)). Family history of migraine: 73.4%. Family history of rosacea: 18.4%. There were 17.1% who currently smoked, and 26.0% former smokers. Regular intake of alcohol was present in 62.2% (median intake: 2 item/week (IQR 1.0–3.0)). Median BMI was 24.6 (IQR 21.5–28.2). Median DLQI was 1 (IQR 0–2).Future plansCOROCO and COMICO serve as strong data sources that will be used for future studies on rosacea and migraine with focus on risk factors, occurrence, treatment, natural history, complications, comorbidities and prognosis.Trial registration numberClinicalTrials.gov Registry (NCT03872050).

Quality of life measurement in rosacea. Position statement of the European Academy of Dermatology and Venereology Task Forces on Quality of Life and Patient Oriented Outcomes and Acne, Rosacea and Hidradenitis Suppurativa

“…From the 207 articles identified in the literature search, 139 were excluded based on the exclusion criteria, leaving 68 publications 20–87 for the further analysis.…”

“…Another generic HRQoL instrument EuroQoL (EQ)‐5D 55,67 and its modifications EQ‐5D‐3L 76 and EQ‐5D‐visual analogue scale 77 were also used to assess quimp in rosacea. The dermatology‐specific Dermatology Life Quality Index (DLQI) was used for quimp assessment in 45 studies on rosacea 20–23,25,28–30,32,34,35,37,40–42,46,48–57,60,62–69,72–74,77,78,80,82,83,86,87 . Data on the DLQI scores from included articles is given in Figure 1.…”

“…Before (Italia) 87 Lockdown mask users. After (Italia) 87 Before treatment (Israel) 54 Online survey (International) 39 Survey (Germany) 63 Survey (Germany) 52 Before treatment (Germany) 50 Online survey (Germany) 49 Treatment group (Germany) 21 Placebo group (Germany) 21 Online survey (Denmark) 35 Outpatients (China) 74 Before treatment in study group (China) 69 Before treatment in control group (China) 69 Outpatients (China) 68 Rosacea patients with anxiety (China) 66 Rosacea patients with depression (China) 66 Rosacea patients without anxiety (China) 66 Rosacea patients without depression (China) 66 Online survey (China) 60 Outpatients and online survey (China) 53 Before treatment (China) 51 Before treatment (China) 20 Median DLQI…”

Evaluation of Dermatological and Neurological Aspects of the Relationship between Rosacea and Headaches

“…Both rosacea and migraine are commonly triggered by factors such as physical and mental stress, specific foods and drinks, exposure to ultraviolet light, as well as extreme temperatures [ 7 , 8 , 9 ]. Additionally, these conditions have been linked to anxiety and depression, significantly impacting the quality of life [ 9 ].…”

“…Both rosacea and migraine are commonly triggered by factors such as physical and mental stress, specific foods and drinks, exposure to ultraviolet light, as well as extreme temperatures [ 7 , 8 , 9 ]. Additionally, these conditions have been linked to anxiety and depression, significantly impacting the quality of life [ 9 ]. On the other hand, headaches include primary types such as tension-type headaches (TTHs), migraines, and cluster-type headaches (CTHs), as well as secondary types (STHs) that arise from pathological conditions [ 10 ].…”