Cohort Profile: French hospital database on HIV (FHDH-ANRS CO4)

Abstract

The French Hospital Database on HIV (FHDH) is a hospital-based multicentre open cohort with inclusions ongoing since 1989. The research objectives focus mainly on mid- and long-term clinical outcomes and therapeutic strategies, as well as severe AIDS and non-AIDS morbidities, and public health issues relative to HIV infection. FHDH also serves to describe HIV-infected patients receiving hospital care in France. FHDH includes data on more than 120,000 HIV-infected patients from 70 French general or university hospitals distributed throughout France. Patients are eligible for inclusion if they are infected by HIV-1 or HIV-2 and give their written informed consent. Standardized variables are collected at each outpatient visit or hospital admission during which a new clinical manifestation is diagnosed, a new treatment is prescribed or a change in biological markers is noted, and/or at least every 6 months. Since its inception, variables collected in FHDH include demographic characteristics, HIV-related biological markers, the date and type of AIDS and non AIDS-defining events, antiretroviral treatments and the date and causes of death, as reported in the medical records. Since 2005, data have also been collected on: co-infection with hepatitis B or C virus; alcohol and tobacco use; and non HIV-related biomarkers. Anyone can submit a research project by completing a standardized form available on the FHDH website (http://www.ccde.fr/_fold/fl-1385734776-429.pdf) or from the corresponding author, describing the context and objectives of the study. All projects are reviewed by the scientific committee.

Impact of age on care pathways of people living with HIV followed up in hospital

“…The demographic and medical characteristics of the participants in our study were in line with those reported in the national French hospital database (FHDH) and the national French VESPA2 survey (Dray-Spira et al, 2013;Mary-Krause et al, 2014).…”

Latent Tuberculosis Infection Screening and 2-Year Outcome in Antiretroviral-Naive HIV-Infected Patients in a Low-Prevalence Country

“…This first estimate for this population in France is in agreement with findings from other low-burden countries: 9.4% in the Swiss cohort, as measured by Mantoux >5 mm (13), and 14.6% in Spain according to IGRAs (14). To rule out recruitment biases, we assessed the representativeness of our study population by comparing them to the ARTnaive HIV-infected patients followed within the French Hospital Database on HIV (FHDH) cohort (16). To rule out recruitment biases, we assessed the representativeness of our study population by comparing them to the ARTnaive HIV-infected patients followed within the French Hospital Database on HIV (FHDH) cohort (16).…”

Access to the waiting list and to kidney transplantation for people living with HIV: A national registry study

“…28 The FHDH ANRS-CO4 uses a unique encrypted identifier that is generated by an algorithm based on the first name, the last name, and the date of birth. A 1:2 (patient:control) ratio was chosen, as this was the highest number of controls we were able to select; we were able to find two HIV-uninfected counterparts with these criteria for almost all PLHIV, but rarely three.…”