Cohort Profile of the Japan Collaborative Cohort Study at Final Follow-up

Abstract

The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was established in the late 1980s to evaluate the risk impact of lifestyle factors and levels of serum components on human health. During the 20-year follow-up period, the results of the study have been published in almost 200 original articles in peer-reviewed English-language journals. However, continued follow-up of the study subjects became difficult because of the retirements of principal researchers, city mergers throughout Japan in the year 2000, and reduced funding. Thus, we decided to terminate the JACC Study follow-up at the end of 2009. As a final point of interest, we reviewed the population registry information of survivors. A total of 207 (0.19%) subjects were ineligible, leaving 110 585 eligible participants (46 395 men and 64 190 women). Moreover, errors in coding date of birth and sex were found in 356 (0.32%) and 59 (0.05%) cases, respectively, during routine follow-up and final review. Although such errors were unexpected, their impact is believed to be negligible because of the small numbers relative to the large total study population. Here, we describe the final cohort profile at the end of the JACC Study along with selected characteristics of the participants and their status at the final follow-up. Although follow-up of the JACC Study participants is finished, we will continue to analyze and publish study results.

Associations of daily walking and television viewing time with liver cancer mortality: findings from the Japan Collaborative Cohort Study

“…The Japan Collaborative Cohort Study for Evaluation of Cancer Risk (JACC Study) was 4 established in 1988-90 and has been described in detail elsewhere [14]. Briefly, 110,585 5 (46,395 men and 64,190 women) apparently healthy inhabitants aged 40 to 79 years 6 from 45 areas throughout Japan were enrolled.…”

Dietary patterns and breast cancer risk in a prospective Japanese study

“…The JACC Study is a large-scale cohort study, started in 1988-90, which has been described in detail elsewhere [26,27]. Briefly, the cohort consisted of 110,585 individuals, 46,395 men and 64,190 women aged 40-79 years, living in 45 areas across Japan.…”

<i>Helicobacter Pylori</i> Infection and Risk of Death From Cardiovascular Disease Among the Japanese Population: a Nested Case-Control Study within the JACC Study

“…For example, a 1998 meta-analysis of 18 studies found no significant association between H. pylori and risk of coronary heart disease (CHD), a major component of CVD 14) . Furthermore, neither of the two recent cohort studies showed a significant, positive associa-Study, 4287 men and 4043 women died from CVD (18). For our nested case-control study, the cases that were selected met the criteria of having provided a baseline blood sample and having died from CHD and stroke, as determined by the JACC Study, during the follow-up until December 31, 2003 18) .…”

“…Furthermore, neither of the two recent cohort studies showed a significant, positive associa-Study, 4287 men and 4043 women died from CVD (18). For our nested case-control study, the cases that were selected met the criteria of having provided a baseline blood sample and having died from CHD and stroke, as determined by the JACC Study, during the follow-up until December 31, 2003 18) . Those who were identified in the JACC Study as being diseasefree at the time the study ended were then selected from the remaining participants as controls 18) .…”

“…For our nested case-control study, the cases that were selected met the criteria of having provided a baseline blood sample and having died from CHD and stroke, as determined by the JACC Study, during the follow-up until December 31, 2003 18) . Those who were identified in the JACC Study as being diseasefree at the time the study ended were then selected from the remaining participants as controls 18) . The controls were matched with the cases in terms of sex, age, and area at a ratio of 1:1.…”