Cohort Profile: Project Viva

Oken, Emily; Baccarelli, Andrea; Gold, Diane R.; Kleinman, Ken; Litonjua, Augusto A.; Meo, Dawn De; Rich‐Edwards, Janet W.; Rifas‐Shiman, Sheryl L.; Sagiv, Sharon K.; Taveras, Elsie M.; Weiss, Scott T.; Belfort, Mandy B.; Burris, Heather H.; Camargo, Carlos A.; Huh, Susanna Y.; Mantzoros, Christos S.; Parker, Margaret G.; Gillman, Matthew W.

doi:10.1093/ije/dyu008

Cited by 310 publications

(290 citation statements)

References 69 publications

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“…Mothers were enrolled between April 1999 and July 2002. Detailed enrollment criteria have been described previously (15). Children were followed from birth.…”

Section: Methods Study Populationmentioning

confidence: 99%

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Lifetime Exposure to Ambient Pollution and Lung Function in Children

Rice

Rifas‐Shiman

Litonjua

et al. 2016

Am J Respir Crit Care Med

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121

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Rationale: Few studies have examined associations between exposure to air pollution and childhood lung function after implementation of strict air quality regulations in the 1990s.Objectives: To assess traffic-related pollution exposure and childhood lung function.Methods: We geocoded addresses for 614 mother-child pairs enrolled during pregnancy in the Boston area 1999-2002 and followed them until a mid-childhood visit (median age, 7.7). We calculated the proximity of the home to the nearest major roadway. We estimated first year of life, lifetime, and prior-year exposure to particulate matter with a diameter smaller than 2.5 mm (PM 2.5 ) by a hybrid model using satellite-derived aerosol optical depth, and to black carbon (BC) by a land-use regression model. Measurements and Main Results:Residential proximity to roadway and prior-year and lifetime PM 2.5 and BC exposure were all associated with lower FVC. Associations with FEV 1 were also negative and proportionally similar. Pollution exposures were not associated with the FEV 1 /FVC ratio or bronchodilator response. Compared with distances greater than or equal to 400 m, living less than 100 m from a major roadway was associated with lower FVC (298.6 ml; 2176.3 to 221.0). Each 2 mg/m 3 increment in prior-year PM 2.5 was associated with lower FVC (221.8 ml; 243.9 to 0.2) and higher odds of FEV 1 less than 80% predicted (1.41; 1.03-1.93). Each 0.2 mg/m 3 increment in prior-year BC was associated with a 38.9 ml (270.4 to 27.3) lower FVC.Conclusions: Estimates of long-term exposure to ambient pollution, including proximity to major roadway, PM 2.5 , and BC (a traffic-related PM 2.5 constituent), were associated with lower lung function in this Boston-area cohort of children with relatively low pollution exposures.

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“…Mothers were enrolled between April 1999 and July 2002. Detailed enrollment criteria have been described previously (15). Children were followed from birth.…”

Section: Methods Study Populationmentioning

confidence: 99%

“…Trained research assistants measured child height, weight, and lung function (15,23). Lung function measurements, including the FEV 1 , the FVC, and the forced expiratory flow at 25-75% of FVC were obtained using the EasyOne Spirometer (NDD Medical Technologies, Andover, MA).…”

Section: Data Collected From Study Participantsmentioning

confidence: 99%

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Rice

Rifas‐Shiman

Litonjua

et al. 2016

Am J Respir Crit Care Med

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121

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“…Details on recruitment and eligibility are described elsewhere (19). All mothers and children originally enrolled in Project Viva and had not subsequently disenrolled were eligible to attend the mid-childhood visit.…”

Section: Methodsmentioning

confidence: 99%

A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood

Perng

Gillman

Mantzoros

et al. 2014

Annals of Epidemiology

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108

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Purpose To examine the relations of maternal pre-pregnancy body mass index (ppBMI) and gestational weight gain (GWG) with offspring cardiometabolic health. Design We studied 1,090 mother-child pairs in Project Viva, a Boston-area pre-birth cohort. We measured overall (DXA total fat; BMI z-score) and central adiposity (DXA trunk fat), and SBP in offspring at 6–10 years. Fasting bloods (n=687) were assayed for insulin and glucose (for calculation of HOMA-IR), triglycerides, leptin, adiponectin, hsCRP and IL-6. Using multivariable linear regression, we examined differences in offspring outcomes per 1 SD maternal ppBMI and GWG. Results After adjustment for confounders, each 5 kg/m2 higher ppBMI corresponded with 0.92 (95% CI: 0.70, 1.14) kg higher total fat, 0.27 (0.21, 0.32) BMI z-score, and 0.39 (0.29, 0.49) kg trunk fat. ppBMI was also positively associated with HOMA-IR, leptin, hsCRP, IL-6, and SBP; and lower adiponectin. Each 5 kg of GWG predicted greater adiposity (0.33 [0.11, 0.54] kg total fat; 0.14 [0.04, 0.23] kg trunk fat) and higher leptin (6% [0%, 13%]) in offspring after accounting for confounders and ppBMI. Conclusions Children born to heavier mothers have more overall and central fat and greater cardiometabolic risk. Offspring of women with higher GWG had greater adiposity and higher leptin.

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“…Eligibility criteria included English speaking, singleton pregnancy, and < 22 weeks gestation. Recruitment procedures have been described in detail elsewhere (15). All women provided written informed consent and the research was approved by the Institutional Review Board at Harvard Pilgrim Health Care.…”

Section: Methodsmentioning

confidence: 99%

Very low maternal lead level in pregnancy and birth outcomes in an eastern Massachusetts population

Perkins

Wright

Amarasiriwardena

et al. 2014

Annals of Epidemiology

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Purpose Maternal lead exposure is associated with poor birth outcomes in populations with moderate to high blood levels. However, no studies have looked at exposure levels commonly experienced by US women. Methods We evaluated the relationship between maternal red blood cell (RBC) lead levels in mid-pregnancy and birth outcomes in 949 mother-child pairs in a pre-birth cohort. We used multiple linear regression and logistic regression, adjusted for potential confounders including maternal age, race, pre-pregnancy BMI and smoking, to relate maternal lead to infant birth size and risk for preterm birth (<37 weeks). Results Mean RBC lead level was 1.2 μg/dL (Range: 0.0, 5.0). Mean (SD) birthweight was 3505 (520) grams, birthweight for gestational age z-score 0.22 (0.93), and length of gestation 39.5 (1.7) weeks. Mothers in the highest vs. lowest lead quartile did not have higher odds (OR 1.85, 95% CI: 0.79, 4.34) of preterm delivery; after stratifying by child sex there was an association among males (OR: 5.51, 95% CI: 1.21, 25.15) but not females (OR 0.82, 95% CI: 0.24, 2.85). Maternal RBC lead was not associated with any continuous outcomes in combined or sex-stratified analyses. Conclusions Maternal lead exposure, even at very low levels, may adversely affect some child birth outcomes, particularly preterm birth among males.

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Cohort Profile: Project Viva

Cited by 310 publications

References 69 publications

Lifetime Exposure to Ambient Pollution and Lung Function in Children

Lifetime Exposure to Ambient Pollution and Lung Function in Children

A prospective study of maternal prenatal weight and offspring cardiometabolic health in midchildhood

Very low maternal lead level in pregnancy and birth outcomes in an eastern Massachusetts population

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