Cohort Profile: The 1895, 1905, 1910 and 1915 Danish Birth Cohort Studies - secular trends in the health and functioning of the very old

Rasmussen, S; Andersen‐Ranberg, Karen; Thinggaard, Mikael; Jeune, Bernard; Skytthe, Axel; Christiansen, Lene; Vaupel, James W.; McGue, Matt; Christensen, Kaare

doi:10.1093/ije/dyx053

Cited by 35 publications

(20 citation statements)

References 45 publications

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“…The COVID-19 strokes and as emergencies continued to developing, the WHO declares global emergency on Jan 31, 2020 (Sohrabi et al, 2020). Older people are more susceptible to a variety of diseases than younger, of course, including COVID-19 infection, which could dramatically increased the healthcare burden under the background of an aging society (Kingston, Robinson, Booth, Knapp, & Jagger, 2018;Rasmussen et al, 2017). The entire population is susceptible to the COVID-19, and the confirmed patients, asymptomatic carrier and people in the incubation period are contagious, it is difficult to control source of infection (Yang & Duan, 2020), and most of the adult patients were old people, who had higher morbidity and case-fatality rate (Sun, Lu, Xu, Sun, & Pan, 2020).…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of older patients infected with COVID-19: A descriptive study

Niu

Tian

Lou

et al. 2020

Archives of Gerontology and Geriatrics

261

215

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Since the outbreak of 2019 novel coronavirus (COVID-19), which has spread in the world rapidly. Population have a susceptibility to COVID-19, older people were more susceptible to have a variety diseases than younger, including COVID-19 infection with no doubt. This study focused on older patients with COVID-19 infection and analyzed the epidemiological and clinical characteristics of them. Methods: We collected information on confirmed older patient transferred by Beijing Emergency Medical Service (EMS) to the designated hospitals from Jan 20 to Feb 29, 2020. The information including demographic, epidemiological, clinical, classification of severity and outcomes. All cases were categorized into three groups and compared the difference between aged 50-64 years, 65-79 years and older than 80 years. Results: 56.7 % of elderly confirmed patients were male, fever (78.3 %), cough (56.7 %), dyspnea (30.0 %), and fatigue (23.3 %) were common symptoms of COVID-19 infection. Classification of severity has statistically significant differences between the three groups, compared with middle-aged patients and aged 65-79 years group, older than 80 years group had significant statistical differences in contacted to symptomatic case in 14 days. As of Feb 29, 38.3 % patients had discharged and 53.3 % patients remained in hospital in our study, the fatality of COVID-19 infection in elderly was 8.3 %. Conclusions: The COVID-19 infection is generally susceptible with a relatively high fatality rate in older patients, we should pay more attention to the elderly patients with COVID-19 infection.

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Section: Discussionmentioning

confidence: 99%

Clinical characteristics of older patients infected with COVID-19: A descriptive study

Niu

Tian

Lou

et al. 2020

Archives of Gerontology and Geriatrics

261

215

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“…Mild cases were defined as confirmed cases with fever, respiratory symptoms and radiographic evidence of pneumonia. Severe cases were defined as mild cases with one of the following conditions: ( 1 ) respiratory rate > 30 times/min; ( 2 ) oxygen saturation < 93% in resting state; ( 3 ) arterial oxygen partial pressure (Pa02)/oxygen concentration (Fi02) <300mmHg; ( 4 ) respiratory failure occurs and mechanical ventilation is required; ( 5 ) shock occurs; ( 6 ) other organ failure occurs and intensive care unit is required. Our study was approved by the ethics committee of West China hospital (No.2020/430) and the written informed consent was waived.…”

Section: Methodsmentioning

confidence: 99%

“…The pathogen has been identified and was named as «COVID-19» in February 11, 2020 ( 2 ). Older populations are more susceptible to variety of diseases compared to younger, including COVID-19 infection ( 3 , 4 ). Although the entire population is susceptible to the COVID-19, older patients had higher morbidity and case-fatality rate ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of Comorbidities on the Elderly Patients with COVID-19: Clinical Characteristics of Elderly Patients Infected with COVID-19 from Sichuan, China

Dai

Zhao

Jin

2021

The Journal of nutrition, health and aging

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Objectives The co-occurrence of chronic diseases in the elderly is a common problem. However, the relationship between comorbidities and the prognosis of elderly patients with COVID-19 was not clear. This study was supposed to describe the clinical characteristics of elderly patients with COVID-19 infection from Sichuan province and the effects of comorbidity. Design A retrospective study. Settings and participants COVID-19 patients from Public Health Clinical Center of Chengdu between December 16, 2019 and February 26, 2020 were included in this study. Patients were divided into elderly group (≥60 years old) and non-elderly group (< 60 years old). Results Elderly patients with COVID-19 indicated relatively higher proportion of comorbidities, and the most common were atherosclerotic cardiovascular disease (56.5%), hypertension (43.5%) and chronic pulmonary disease (21.7%). The proportion of severe cases was higher in elderly group than that in non-elderly group (73.9% and 42.2%, respectively, P=0.012). During hospitalization, elderly patients indicated relatively higher proportion of complications, such as shock (21.7%), respiratory failure (21.7%). The proportion of patients with a decreased number of CD8+ lymphocytes (82.6%) and B lymphocytes (77.8%) in elderly patients was significantly higher than that in non-elderly group (48.9% and 44.8%, respectively). All 3 deaths were elderly patients with comorbidities and the cell counts of T lymphocyte subsets, B and NK cells of them were significantly decreased at admission. Conclusions Elderly patients with COVID-19 had a high proportion of severe cases and comorbidities, more likely to show low immune function, and indicate higher proportion of complications.

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“…We searched for studies focusing on protective factors for cognitive impairment in nonagenarians, which gave us two results: The 90+ Study in the USA and the Danish Birth Cohort Studies [ 6 , 7 ]. Broadening the search to studies that started inclusion from the age of 85 years or focused on successful aging resulted in eight more studies: the H85 Gothenburg study, Leiden 85-plus Study, Newcastle 85+ Study, NonaSantfeliu study, Octabaix study, Project of Longevity and Aging in Dujangyan (PLAD), Umeå study and Vantaa 85+ Study [ 8 – 15 ].…”

Section: Introductionmentioning

confidence: 99%

Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study

et al. 2018

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BackgroundThe oldest-old (subjects aged 90 years and older) population represents the fastest growing segment of society and shows a high dementia prevalence rate of up to 40%. Only a few studies have investigated protective factors for cognitive impairment in the oldest-old. The EMIF-AD 90+ Study aims to identify factors associated with resilience to cognitive impairment in the oldest-old. In this paper we reviewed previous studies on cognitive resilience in the oldest-old and described the design of the EMIF-AD 90+ Study.MethodsThe EMIF-AD 90+ Study aimed to enroll 80 cognitively normal subjects and 40 subjects with cognitive impairment aged 90 years or older. Cognitive impairment was operationalized as amnestic mild cognitive impairment (aMCI), or possible or probable Alzheimer’s Disease (AD). The study was part of the European Medical Information Framework for AD (EMIF-AD) and was conducted at the Amsterdam University Medical Centers (UMC) and at the University of Manchester. We will test whether cognitive resilience is associated with cognitive reserve, vascular comorbidities, mood, sleep, sensory system capacity, physical performance and capacity, genetic risk factors, hallmarks of ageing, and markers of neurodegeneration. Markers of neurodegeneration included an amyloid positron emission tomography, amyloid β and tau in cerebrospinal fluid/blood and neurophysiological measures.DiscussionThe EMIF-AD 90+ Study will extend our knowledge on resilience to cognitive impairment in the oldest-old by extensive phenotyping of the subjects and the measurement of a wide range of potential protective factors, hallmarks of aging and markers of neurodegeneration.Trial registrationNederlands Trial Register NTR5867. Registered 20 May 2016.Electronic supplementary materialThe online version of this article (10.1186/s12877-018-0984-z) contains supplementary material, which is available to authorized users.

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Cohort Profile: The 1895, 1905, 1910 and 1915 Danish Birth Cohort Studies - secular trends in the health and functioning of the very old

Cited by 35 publications

References 45 publications

Clinical characteristics of older patients infected with COVID-19: A descriptive study

Clinical characteristics of older patients infected with COVID-19: A descriptive study

Effects of Comorbidities on the Elderly Patients with COVID-19: Clinical Characteristics of Elderly Patients Infected with COVID-19 from Sichuan, China

Resilience to cognitive impairment in the oldest-old: design of the EMIF-AD 90+ study

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