Cohort profile: the ChicagO Multiethnic Prevention and Surveillance Study (COMPASS)

Abstract

PurposeThe ChicagO Multiethnic Prevention and Surveillance Study or ‘COMPASS’ is a population-based cohort study with a goal to examine the risk and determinants of cancer and chronic disease. COMPASS aims to address factors causing and/or exacerbating health disparities using a precision health approach by recruiting diverse participants in Chicago, with an emphasis on those historically underrepresented in biomedical research.ParticipantsNearly 8000 participants have been recruited from 72 of the 77 Chicago community areas. Enrolment entails the completion of a 1-hour long survey, consenting for past and future medical records from all sources, the collection of clinical and physical measurement data and the on-site collection of biological samples including blood, urine and saliva. Indoor air monitoring data and stool samples are being collected from a subset of participants. On collection, all biological samples are processed and aliquoted within 24 hours before long-term storage and subsequent analysis.Findings to dateThe cohort reported an average age of 53.7 years, while 80.5% identified as African-American, 5.7% as Hispanic and 47.8% as men. Over 50% reported earning less than US$15 000 yearly, 35% were obese and 47.8% were current smokers. Moreover, 38% self-reported having had a diagnosis of hypertension, while 66.4% were measured as hypertensive at enrolment.Future plansWe plan to expand recruitment up to 100 000 participants from the Chicago metropolitan area in the next decade using a hybrid community and clinic-based recruitment framework that incorporates data collection through mobile medical units. Follow-up data collection from current cohort members will include serial samples, as well as longitudinal health, lifestyle and behavioural assessment. We will supplement self-reported data with electronic medical records, expand the collection of biometrics and biosamples to facilitate increasing digital epidemiological study designs and link to state and/or national level databases to ascertain outcomes. The results and findings will inform potential opportunities for precision disease prevention and mitigation in Chicago and other urban areas with a diverse population.RegistrationNA.

A metabolome-wide case-control study of african american breast cancer patients

“…The healthy controls were selected from the Chicago Multiethnic Prevention and Surveillance Study (COMPASS), a large scale, longitudinal cohort study with a current sample size of 7728 participants from 72 of the 77 Chicago community areas [ 39 ]. Residents of the greater Chicago area were eligible for COMPASS if they were: (1) 18 or older at the time of enrollment; (2) able to give consent and provide survey data in English or Spanish; (3) willing to provide blood, urine, saliva samples, and access to medical records.…”

The Role of Health Insurance Type and Clinic Visit on Hypertension Status Among Multiethnic Chicago Residents

“…Details of COMPASS have been described elsewhere. 32 Briefly, people are eligible for COMPASS if they are: (1) age 18 or older at the time of enrollment; (2) able to give consent and provide survey data in English or Spanish; (3) willing to provide blood, urine, and saliva samples as well as electronic health record access. COMPASS has employed multiple recruitment modalities in different settings, including a population-based approach, a community-based approach, and a hospital/clinic-based approach.…”

“…Details of COMPASS have been described elsewhere. 32 Briefly, people are eligible for COM-PASS if they are: (1) age 18 or older at the time of enrollment;…”

Urban Spatial Accessibility of Primary Care and Hypertension Control and Awareness on Chicago’s South Side: A Study From the COMPASS Cohort

“…Details of COMPASS have been described elsewhere. 12 Residents of the greater Chicago area are eligible for COMPASS if they are (1) age 35 or older at the time of enrollment; (2) able to give consent and provide survey data in English or Spanish; (3) willing to provide blood, urine, and saliva samples as well as electronic health record access. COMPASS has employed multiple recruitment modalities, including a population-based approach, a community-based approach, and a hospital/clinic-based approach.…”

“…11 On the Chicago's South Side, the largest continuous Black urban community in the United States, longstanding structural racism in the housing system has led to substantial challenges including concentrated poverty, violence, and food deserts. 12,13 A 30-year gap in life expectancy has been observed between South Side neighborhoods and Chicago's wealthier northern neighborhoods, 14 which could be largely attributable to high rates of hypertension, heart disease, and stroke. 15 A shortage of medical resources that prevents South Side residents from accessing primary care contributes to these alarming racial inequalities in health.…”