Cohort Profile: the Etude Epidémiologique sur les Petits Ages Gestationnels-2 (EPIPAGE-2) preterm birth cohort

Tocolysis in the management of preterm prelabor rupture of membranes at 22–33 weeks of gestation: study protocol for a multicenter, double-blind, randomized controlled trial comparing nifedipine with placebo (TOCOPROM)

“…This is an average estimate taking into account the expected variation of gestational age at birth in our study population from 22 to 37+ weeks. This estimate is consistent with findings in recent studies [15,52,66].…”

“…About 50 to 60% of women will give birth within the first week after PPROM [8][9][10], which is thus responsible for a large share of preterm births (25 to 30%) [1,11] and is a leading cause of neonatal mortality and morbidity and maternal infectious morbidity [7,12]. Although the infant's prognosis depends mainly on gestational age at birth [13][14][15], fetal exposure to inflammation, infection, and acute obstetric complications (placental abruption, umbilical cord compression or prolapse) can increase short-and long-term mortality/morbidity [16][17][18]. Consequently, in cases of PPROM, medical teams must weigh the benefits of prolonging pregnancy to reduce prematurity-related adverse consequences against those of inducing delivery to shorten exposure to intrauterine inflammation, infection, and acute obstetric complications.…”

“…Antenatal management of women follows tertiary prevention principles and aims to reduce maternal, fetal, and neonatal adverse consequences [19]. With PPROM before 34 weeks, current evidence-based care includes expectant management in the absence of labor, overt infection, or fetal distress [20][21][22][23] to increase gestational age at birththe main determinant of the preterm child's prognosis [13][14][15]. Routine administration of antibiotics is recommended to prolong pregnancy and reduce neonatal and maternal morbidity [24][25][26][27].…”

Antibiotic prophylaxis in preterm premature rupture of membranes at 24–31 weeks’ gestation: Perinatal and 2‐year outcomes in the EPIPAGE‐2 cohort

“…This is a secondary analysis of the EPIPAGE-2 cohort, a prospective national population-based cohort of preterm infants that included all live born or stillborn infants and all terminations of pregnancy at 22-34 completed weeks' gestation in all maternity units from 25 regions in France in 2011. 17 Recruitment took place at birth, after families had received information and agreed to participate. Infants were included at three different periods by gestational age at birth: 8-month recruitment for births at 22-26 weeks, 6-month recruitment for 27-31 weeks, and 5-week recruitment for 32-34 weeks.…”

“…Maternal, obstetric and neonatal data were collected from medical records following a standardised protocol as previously reported. 17 At 2 years of corrected age, children participating in the follow-up were assessed with a detailed neurological and sensory examination performed by their referring physician, and a standardised questionnaire about development was completed by the parents. 18 The cohort relies on several sources of funding through grants awarded after external peer review for scientific quality.…”