Cohort Profile: The Fremantle Diabetes Study

Davis, Timothy; Bruce, David; Davis, Wendy A.

doi:10.1093/ije/dys065

Cited by 116 publications

(242 citation statements)

References 65 publications

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“…In this matched cohort study, we used administrative health data sets to identify dementia in participants with type 2 diabetes from the FDS1, a representative sample from an urban Australian community [21], and residents without diabetes matched by age, sex and postcode. The main aim was to compare the natural history, incidence and risk of dementia in the two groups.…”

Section: Discussionmentioning

confidence: 99%

“…The present study has several strengths. It was conducted in a community-based cohort with accurately diagnosed type 2 diabetes that was representative of the urban Australian diabetes community [21] and in carefully matched residents without diabetes, including matching to the level of Australian postcodes. Matching and dementia case-finding used WADLS, an established, well-developed and validated data linkage system.…”

Section: Discussionmentioning

confidence: 99%

“…Descriptions of recruitment, sample characteristics, including classification of diabetes type, and details of non-recruited patients have been published elsewhere [21]. Of 2258 residents with diabetes identified between 1993 and 1996, 1426 (63%) were recruited to the FDS1 and 1296 had type 2 diabetes.…”

Section: Methodsmentioning

confidence: 99%

“…The participants were recruited between 1993 and 1996 and followed with annual face-to-face clinical assessments for a further 5 years [21]. We have previously reported risk factor data for dementia and cognitive decline in middle-aged and older subsamples of FDS1 survivors with type 2 diabetes [22][23][24].…”

Section: Introductionmentioning

confidence: 99%

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Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I

et al. 2016

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Aims/hypothesis The study aimed to assess the incidence, age of onset, survival and relative hazard of dementia in wellcategorised community-based patients with type 2 diabetes compared with a matched cohort of individuals without diabetes. Methods A longitudinal observational study was undertaken involving 1291 participants with type 2 diabetes from the Fremantle Diabetes Study and 5159 matched residents without documented diabetes. Linkage with health-related databases was used to detect incident dementia. Relative hazards were assessed using both cause-specific and subdistribution proportional hazards models. Results During 13.8 ± 5.8 years of follow-up, incident dementia occurred in 13.9% and 12.4% of the groups of participants with and without diabetes, respectively (p = 0.15). With type 2 diabetes, the incidence of dementia was higher (incidence rate ratio [IRR] 1.28, 95% CI 1.08, 1.51), as was the competing risk of death (IRR 1.50, 95% CI 1.38, 1.64). The ages when dementia was first recorded and when death with dementia occurred were both earlier with diabetes, by 1.7 (95% CI 0.6, 2.9) and 2.3 (95% CI 1.1, 3.6) years, respectively (both p ≤ 0.004). Type 2 diabetes was associated with an adjusted subdistribution HR of 1.18 (95% CI 1.00, 1.39), and a causespecific HR of 1.51 (95% CI 1.27, 1.78) for all-cause dementia. Conclusions/interpretation Type 2 diabetes is associated with an increased incidence of dementia, and dementia onset occurs at a younger age. The relative hazards of both dementia and premature mortality are increased and, as a consequence, the increased risk of dementia in type 2 diabetes is not as marked as suggested by cause-specific HRs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I

et al. 2016

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“…In a study which was done by Davis. A Wendy et al, it was found that there was a decrease in mean FVC values in type 2 diabetics [7,9]. In a study which was done by Robert E. Walter et.al., it was found that there was a progressive decrease in mean FVC values by 109 ml/year [10].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Function Tests in Type 2 Diabetics and Non-Diabetic People -A Comparative Study

Aparna¹

2013

JCDR

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Background: The complications which are associated with type 2 Diabetes mellitus are mostly caused by macro vascular and micro vascular damages. The pulmonary complications of diabetes mellitus have been poorly characterised. The present study has focused on the mechanical aspects of lung dysfunction which are attributable to type 2 Diabetes Mellitus; maximal forced Spiro metric Pulmonary Function Tests (PFTs) like Forced vital capacity (FVC), Forced Expiratory Volume in 1sec (FEV1),. FEV1/FVC % and Peak expiratory flow rate (PEFR), to be specific.Aims and objectives: 1. To do a comparative analysis of the PFTs in type 2 diabetics and non-diabetics by using computerised spirometry. 2. To assess the effects of chronic hyperglycaemia on lung functions and functional limitations of activities of daily living which are ascribable to pulmonary complications, in patients with type 2 diabetes. Material and Methods:Spirometry was performed by using a computerised electronic spirometer, (RMS Helios 401, version 3-1-59, transducer number 4-16-1669) on 40 type 2 diabetics who were between 40-65 years of age and on 40 controls (who were matched for age, sex and BMI). Any person with a H/O smoking or any condition which affected the lung functions, was excluded from the study. The study was a cross sectional and a retrospective study. Data was analyzed and processed with the help of EPI INFO statistical software by using unpaired Student's 't'-test (two-tailed). The level of significance was taken as a p-value of <0.025.

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Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus

et al. 2017

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IntroductionType 2 diabetes mellitus is associated with global and hippocampal atrophy and cognitive deficits, and some studies suggest that the right hippocampus may display greater vulnerability than the left.MethodsHippocampal volumes, the hippocampal asymmetry index, and cognitive functioning were assessed in 120 nondemented adults with long duration type 2 diabetes.ResultsThe majority of the sample displayed left greater than right hippocampal asymmetry (which is the reverse of the expected direction seen with normal aging). After adjustment for age, sex, and IQ, right (but not left) hippocampal volumes were negatively associated with memory, executive function, and semantic fluency. These associations were stronger with the hippocampal asymmetry index and remained significant for memory and executive function after additional adjustment for global brain atrophy.ConclusionsWe conclude that asymmetric hippocampal atrophy may occur in type 2 diabetes, with greater atrophy occurring in the right than the left hippocampus, and that this may contribute to cognitive impairment in this disorder. These cross‐sectional associations require further verification but may provide clues into the pathogenesis of cognitive disorders in type 2 diabetes.

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Cohort Profile: The Fremantle Diabetes Study

Cited by 116 publications

References 65 publications

Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I

Dementia onset, incidence and risk in type 2 diabetes: a matched cohort study with the Fremantle Diabetes Study Phase I

Pulmonary Function Tests in Type 2 Diabetics and Non-Diabetic People -A Comparative Study

Hippocampal atrophy, asymmetry, and cognition in type 2 diabetes mellitus

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