Cohort Profile: The Kadoorie Study of Chronic Disease in China (KSCDC)

Chen, Zhengming; Li, Liming; Chen, Junshi; Collins, Rory; Wu, Fan; Guo, Yu; Linksted, Pamela; Pető, Richárd

doi:10.1093/ije/dyi174

Cited by 358 publications

(337 citation statements)

References 9 publications

Supporting

Mentioning

335

Contrasting

Unclassified

Order By: Relevance

“…Participants were from 10 regions covering 5 rural counties (Gansu, Henan, Zhejiang, Sichuan, and Hunan provinces) and 5 urban cities (Harbin, Qingdao, Suzhou, Liuzhou, and Haikou); among these 10 regions, 4 are located in north China (Harbin, Qingdao, Gansu, and Henan), whereas the other 6 are in the south. The cohort design, sampling strategy, and baseline characteristics were reported elsewhere 18, 19. A total of 512 891 adult residents aged 30 to 79 years were enrolled between 2004 and 2008.…”

Section: Methodsmentioning

confidence: 99%

“…Information on incident IHD was regularly collected through linkage with the regional disease registry system and, through unique national identifiers, with an established national health insurance system, which records details of International Classification of Diseases, 10th Revision (ICD‐10) coded hospitalization information 18. The vital status of each participant was obtained by linkage to China's Disease Surveillance Points system, checked annually against local residential cards, health insurance records, and local street committees 19.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Self‐Rated Health Status and Risk of Ischemic Heart Disease in the China Kadoorie Biobank Study: A Population‐Based Cohort Study

Dong

Pan

Yu³

et al. 2017

JAHA

Self Cite

View full text Add to dashboard Cite

BackgroundSelf‐rated health (SRH) is a strong predictor of mortality in different populations. However, the associations between SRH measures and risk of ischemic heart disease (IHD) have not been extensively explored, especially in a Chinese population.Methods and ResultsMore than 500 000 adults from 10 cities in China were followed from baseline (2004–2008) through December 31, 2013. Global and age‐comparative SRH were reported from baseline questionnaires. Incident IHD cases were identified through links to well‐established disease registry systems and the national health insurance system. During 3 423 542 person‐years of follow‐up, we identified 24 705 incident cases of IHD. In multivariable‐adjusted models, both global and age‐comparative SRH was significantly associated with incident IHD. Compared with excellent SRH, the hazard ratios for good, fair, and poor SRH were 1.02 (95% confidence interval [CI], 0.98–1.07), 1.32 (95% CI, 1.27–1.37), and 1.76 (95% CI, 1.68–1.85), respectively. Compared with better age‐comparative SRH, the hazard ratios for same and worse age‐comparative SRH were 1.23 (95% CI, 1.19–1.27) and 1.78 (95% CI, 1.70–1.86), respectively. The associations persisted in all subgroup analyses, although they were slightly modified by study location, education, and income levels.ConclusionsA simple questionnaire for self‐assessment of health status was significantly associated with incident IHD in Chinese adults. Individuals and healthcare providers can use SRH measures as a convenient tool for assessing future IHD risk.

show abstract

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Self‐Rated Health Status and Risk of Ischemic Heart Disease in the China Kadoorie Biobank Study: A Population‐Based Cohort Study

Dong

Pan

Yu³

et al. 2017

JAHA

Self Cite

View full text Add to dashboard Cite

show abstract

“…To help address these issues, we report cross‐sectional data from the China Kadoorie Biobank of 0.5 million people 8. The objectives were to examine: 1) the relationship between self‐reported, doctor‐diagnosed diabetes and the prevalence of cardiovascular disease; 2) the relevance of age, sex, area, education, smoking status, alcohol consumption, blood pressure, physical activity and adiposity to observed associations; and 3) the association between random blood glucose levels and the prevalence of cardiovascular disease among people without prior diabetes.…”

Section: Introductionmentioning

confidence: 99%

Associations of blood glucose and prevalent diabetes with risk of cardiovascular disease in 500 000 adult Chinese: the China Kadoorie Biobank

Bragg

Smith

et al. 2014

Diabet. Med.

View full text Add to dashboard Cite

AimsTo examine the relationship of self‐reported diabetes, and of random blood glucose levels among individuals without known diabetes, with the prevalence of cardiovascular disease in Chinese adults.MethodsWe examined cross‐sectional data from the China Kadoorie Biobank of 0.5 million people aged 30–79 years recruited from 10 diverse regions of China in the period 2004–2008. Logistic regression was used to estimate the odds ratios of prevalent cardiovascular disease associated with self‐reported diabetes, and with measured random blood glucose levels among participants with no history of diabetes, adjusting simultaneously for age, sex, area, education, smoking, alcohol, blood pressure and physical activity.ResultsA total of 3.2% of participants had self‐reported diabetes (men 2.9%; women 3.3%) and 2.8% had screen‐detected diabetes (men 2.6%; women 2.8%), i.e. they had no self‐reported history of diabetes but a blood glucose level suggestive of a diagnosis of diabetes. Compared with individuals without a history of diabetes, the odds ratios associated with self‐reported diabetes were 2.18 (95% CI 2.06–2.30) and 1.88 (95% CI 1.75–2.01) for prevalent ischaemic heart disease and stroke/transient ischaemic attack, respectively. Among participants without self‐reported diabetes there was a positive association between random blood glucose and ischaemic heart disease and stroke/transient ischaemic attack prevalence (P for trend <0.0001). Below the diabetic threshold (<11.1 mmol/l) each additional 1 mmol/l of random blood glucose was associated with 4% (95% CI 2–5%) and 5% (95% CI 3–7%) higher odds of prevalent ischaemic heart disease and stroke/transient ischaemic attack, respectively.ConclusionsIn this adult Chinese population, self‐reported diabetes was associated with a doubling of the odds of prevalent cardiovascular disease. Below the threshold for diabetes there was still a modest, positive association between random blood glucose and prevalent cardiovascular disease.

show abstract

“…And the people that biobanks seek to help rarely involve the poorest of the poor in lowincome countries, though a few exceptions do of course exist. [87][88][89] Besides sharing of medical benefits, the sharing of potential financial benefits is a pertinent issue. 90 The actual size of financial benefits is contested and only limited amounts of evidence are publically available.…”

Section: Ethical Issuesmentioning

confidence: 99%

Size matters: the ethical, legal, and social issues surrounding large-scale genetic biobank initiatives

Hoeyer¹

2012

Nor J Epidemiol

View full text Add to dashboard Cite

During the past ten years the complex ethical, legal and social issues (ELSI) typically surrounding large-scale genetic biobank research initiatives have been intensely debated in academic circles. In many ways genetic epidemiology has undergone a set of changes resembling what in physics has been called a transition into Big Science. This article outlines consequences of this transition and suggests that the change in scale implies challenges to the roles of scientists and public alike. An overview of key issues is presented, and it is argued that biobanks represent not just scientific endeavors with purely epistemic objectives, but also political projects with social implications. As such, they demand clever maneuvering among social interests to succeed.

show abstract

Cohort Profile: The Kadoorie Study of Chronic Disease in China (KSCDC)

Cited by 358 publications

References 9 publications

Self‐Rated Health Status and Risk of Ischemic Heart Disease in the China Kadoorie Biobank Study: A Population‐Based Cohort Study

Self‐Rated Health Status and Risk of Ischemic Heart Disease in the China Kadoorie Biobank Study: A Population‐Based Cohort Study

Associations of blood glucose and prevalent diabetes with risk of cardiovascular disease in 500 000 adult Chinese: the China Kadoorie Biobank

Size matters: the ethical, legal, and social issues surrounding large-scale genetic biobank initiatives

Contact Info

Product

Resources

About