Cohort Profile: The PROLIFE study in Kerala, India

Soman, C. R.; Shahulhameed, Safraj; Ramankutty, V.; Vijayakumar, K.; Kunjukrishnapillai, Rajamohanan; Kamalasanan, Ajayan; Sajikumar, Sarasan

doi:10.1093/ije/dyp275

Cited by 25 publications

(31 citation statements)

References 3 publications

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“…8 According to the PROLIFE study it was shown that the coronary heart disease death rates in women is only about half that in men. 9 This difference is attributed at least partly to the favourable effects of oestrogens on serum lipid concentrations. 10 Menopause has a great effect on the circulating levels of lipids and lipoproteins.…”

Section: Discussionmentioning

confidence: 99%

Effect of surgical menopause on serum lipid profile-a prospective study

2018

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INTRODUCTIONFor most women menopause marks the beginning of uninterrupted oestrogen deficiency and indicates the onset of permanent cessation of ovarian function.Menopause is diagnosed after 12months of amenorrhea and the mean age at menopause is 51years. It has been shown than several symptoms and diseases have a causal association with menopause.1 The Prospective Pittsburgh Study has found that menopause is associated with changes in several heart disease risk factors such as increasing LDL cholesterol and decreasing HDL cholesterol. Natural menopause has an unfavourable effect on lipid metabolism which may contribute to an increase in the risk of coronary artery disease. 2 Women with premature menopause (before the age of 40years) or early menopause (between 40 and 45years) experience an increased risk of overall mortality cardiovascular disease, psychiatric disease, osteoporosis and other sequelae. ABSTRACTBackground: Menopause marks the onset of cessation of ovarian function which is associated with changes in cardiovascular risk factors especially an unfavourable change in lipid profile. This is more pronounced is perimenopausal females who have undergone total hysterectomy with bilateral sapingo oopherectomy. This study aimed at looking into the changes occurring in the lipid profile and other cardiovascular risk in patients who have underwent oopherectomy over a 3 months period. Methods: The study was conducted as a case control one. We studied 70 consecutive perimenopausal patients admitted in a tertiary care teaching medical college hospital in Kerala, South India who were admitted for hysterectomy and bilateral oopherectomy over a 1year period. The lipid profile and anthropometric measurement with blood pressure recording was done prior to surgery and the same patients were followed up after 3 months when the cardiovascular risk assessment and lipid profile estimation were repeated. Here, the cases acted as controls after the end of third month. Results: It was found that after the end of 3 months of surgical menopause there was no significant change in body mass index, waist hip ratio or systolic BP. However, the DBP was higher in patients after surgery (78.68±7.94 vs 83.31±11.03, P <0.001). There was also statistically significant increase in total cholesterol (166.07±28.22 vs 242.94±45.65 [P<0.001]), TG (129.33±31.16 vs 177.06±50.57 P<0.001) and LDLc (107.83±20.06 vs 166.73±48.51 P>0.001). The HDLc was found to be 27% after 3 months of surgical menopause (59.31±8.22 vs 43.73±35 P>0.001. Conclusions: Thus, it was concluded that there was a significant unfavourable effects on lipid profile and diastolic blood pressure 3 months after surgical menopause.

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Section: Discussionmentioning

confidence: 99%

Effect of surgical menopause on serum lipid profile-a prospective study

2018

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“…20 In our community, 41% of people had sedentary habits, 10% had self-reported diabetes, and 9.4% had self-reported hypertension. 7 The very high mortality from CHD and stroke indicates that CVD is quite high in Kerala. After presentation, these diseases demand lifetime management often necessitating expensive interventions.…”

Section: Discussionmentioning

confidence: 99%

All-Cause Mortality and Cardiovascular Mortality in Kerala State of India

Soman

Kutty

Shahulhameed

et al. 2010

Asia Pac J Public Health

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“…[10] Briefl y PROLIFE is a prospective cohort study launched on 1 st July 2002 on close to 1,61,942 participants residing in Varkala rural development block in Trivandrum district of the South Indian state, Kerala. Data have been collected on events including death in the cohort till 31 st December 2007.…”

Section: Methodsmentioning

confidence: 99%

“…Follow-up has been achieved for more than 80% of the cohort. [10] Information about each participant's educational attainment (schooling in a number of years), socio economic status and age was obtained from the investigator administered questionnaire. Every home in which a death had been recorded was visited by nonmedical fi eld surveyors to obtain information about the cause of death, occupation, education and alcohol use.…”

Section: Methodsmentioning

confidence: 99%

Risk of mortality among alcohol using adult males in a population-based cohort in Kerala, India: PROFILE study

Vijayakumar

Philip

Marinaik

et al. 2015

Int J Med Public Health

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Context: Information on the pattern of mortality among alcohol users is important for advocacy and planning. The proportion of deaths attributed to alcohol is often underestimated. Aim: We determined the risk of mortality among alcohol using adult males compared with adult male nonalcohol users. Settings and Design: Cohort study was conducted in the population registry of lifestyle diseases cohort in a rural block in Kerala, India. Materials and Methods: During 2002-2007, trained fi eld workers conducted interviews, and underlying cause of death was coded by local physicians trained in verbal autopsy. Statistical Analysis: Risk ratios of death among men using alcohol and not using alcohol were calculated. Risk ratio of alcohol for various causes of mortality across various age groups was also determined. Log-rank test was done to compare the mortality of adult men using and not using alcohol. Results: Risk ratios of all-cause mortality in alcoholic men were 1.87 (1.45, 2.4) in 20-44 age group, 1.3 (1.07, 1.57) for 45-59 age group. Relative risks of alcohol use status for coronary heart disease mortality were 2.91 (1.67, 5.05) among 20-44 years and 1.49 (1.09, 2.03) among 45-59 years. Conclusion: Young and middle-aged male alcohol users (20-59 years) showed signifi cantly increased risk ratio of death. Alcohol users have a higher risk of coronary artery disease mortality and mortality from injuries. The results support a restrictive alcohol policy and screening for coronary artery disease in men using alcohol seeking care in treatment facilities.

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Cohort Profile: The PROLIFE study in Kerala, India

Cited by 25 publications

References 3 publications

Effect of surgical menopause on serum lipid profile-a prospective study

Effect of surgical menopause on serum lipid profile-a prospective study

All-Cause Mortality and Cardiovascular Mortality in Kerala State of India

Risk of mortality among alcohol using adult males in a population-based cohort in Kerala, India: PROFILE study

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