Cohort Profile: The Rotterdam Periconceptional Cohort (Predict Study)

Steegers‐Theunissen, Régine P.M.; Verheijden-Paulissen, Jennifer Jfm; Uitert, E.M. van; Wildhagen, Mark F.; Exalto, N.; Koning, Anton H. J.; Eggink, Alex J.; Duvekot, Johannes J.; Laven, Joop S.E.; Tibboel, Dick; Reiss, Irwin; Steegers, Eric A.P.

doi:10.1093/ije/dyv147

Cited by 98 publications

(80 citation statements)

References 25 publications

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“…Cases were collected at the department of Obstetrics and Prenatal Medicine at Erasmus MC University Medical Center Rotterdam ( n = 47) and at Hôpital Princesse Grace Monaco ( n = 15). Additional cases ( N = 9) were included from the Rotterdam Predict study [11], a periconception cohort aimed at early pregnancy. Ultrasound scans were performed using the Voluson E8 Expert system (GE Medical Systems, Zipf, Austria) by operators experienced in collecting 3D ultrasound datasets.…”

Section: Methodsmentioning

confidence: 99%

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First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural Congenital Abnormalities Measured in Virtual Reality: An Observational Study

Baken

Benoit

Koning

et al. 2017

BioMed Research International

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Background. With the introduction of three-dimensional (3D) ultrasound it has become possible to measure volumes. The relative increase in embryonic volume (EV) is much larger than that of the crown-rump length (CRL) over the same time period. We examined whether EV is a better parameter to determine growth restriction in fetuses with structural congenital abnormalities. Study Design, Subjects, and Outcome Measures. CRL and EV were measured using a Virtual Reality (VR) system in prospectively collected 3D ultrasound volumes of 56 fetuses diagnosed with structural congenital abnormalities in the first trimester of pregnancy (gestational age 7+5 to 14+5 weeks). Measured CRL and EV were converted to z-scores and to percentages of the expected mean using previously published reference curves of euploid fetuses. The one-sample t-test was performed to test significance. Results. The EV was smaller than expected for GA in fetuses with structural congenital abnormalities (−35% p < 0.001, z-score −1.44 p < 0.001), whereas CRL was not (−6.43% p = 0.118, z-score −0.43 p = 0.605). Conclusions. CRL is a less reliable parameter to determine growth restriction in fetuses with structural congenital abnormalities as compared with EV. By measuring EV, growth restriction in first-trimester fetuses with structural congenital abnormalities becomes more evident and enables an earlier detection of these cases.

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Section: Methodsmentioning

confidence: 99%

“…It is well known that first-trimester growth is associated with pregnancy outcome [7–10] and that several factors like maternal factors and dietary pattern influence first-trimester growth [11–13]. Traditionally, first-trimester fetal growth has been documented by two-dimensional (2D) crown-rump length (CRL) measurements.…”

Section: Introductionmentioning

confidence: 99%

First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural Congenital Abnormalities Measured in Virtual Reality: An Observational Study

Baken

Benoit

Koning

et al. 2017

BioMed Research International

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“…This study was embedded in the ongoing Rotterdam Periconceptional Cohort study . Between November 2013 and July 2015, we invited women with an ongoing singleton pregnancy for prenatal 3D US examinations in the second and third trimesters of pregnancy and for cranial ultrasounds in the neonatal period.…”

Section: Methodsmentioning

confidence: 99%

“…Maternal, obstetrical and neonatal outcome data were collected from questionnaires at enrolment, at 24 weeks of gestation and after birth . Postnatal data included gender, GA at birth and birth weight.…”

Section: Methodsmentioning

confidence: 99%

Foetal fractional thigh volume: an early 3D ultrasound marker of neonatal adiposity

et al. 2017

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“…The GA was calculated according to the first day of the last menstrual period in case of a regular menstrual cycle of 28 days and adjusted for a longer or shorter cycle [14]. In case of a discrepancy in GA of > 7 days between crown-rump length (CRL) and the last menstrual period or an unknown last menstrual period, the GA was calculated by using CRL according to Robinson and Fleming [15] at the end of the first trimester using the latest available measurement.…”

Section: Pregnancy Datingmentioning

confidence: 99%

Evaluation of First-Trimester Physiological Midgut Herniation Using Three-Dimensional Ultrasound

Bogers¹,

Baken²,

Cohen–Overbeek³

et al. 2018

Fetal Diagn Ther

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Introduction:The aim of this study was to investigate the development of midgut herniation in vivo using three-dimensional (3D) ultrasonographic volume and distance measurements and to create reference data for physiological midgut herniation in ongoing pregnancies in a tertiary hospital population. Materials and Methods: The transvaginal 3D ultrasound volumes of 112 women, seen weekly during the first trimester of pregnancy, were obtained and subsequently analysed in a virtual reality environment. The width of the umbilical cord insertion, the maximum diameter of the umbilical cord, and the volume of midgut herniation were measured from 6 until 13 weeks gestational age (GA). Results: All parameters had a positive relation with GA, crownrump length, and abdominal circumference. In approximately 1 of 10 volumes no midgut herniation could be observed at 9 and 10 weeks GA. In 5.0% of the fetuses the presence of midgut herniation could still be visualised at 12 weeks GA. Conclusion: Reference charts for several dimensions of physiological midgut herniation were created. In the future, our data might be used as a reference in the first trimester for comparison in case of a suspected pathological omphalocele.

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Cohort Profile: The Rotterdam Periconceptional Cohort (Predict Study)

Cited by 98 publications

References 25 publications

First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural Congenital Abnormalities Measured in Virtual Reality: An Observational Study

First-Trimester Crown-Rump Length and Embryonic Volume of Fetuses with Structural Congenital Abnormalities Measured in Virtual Reality: An Observational Study

Foetal fractional thigh volume: an early 3D ultrasound marker of neonatal adiposity

Evaluation of First-Trimester Physiological Midgut Herniation Using Three-Dimensional Ultrasound

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