Cohort profile: the Taicang and Wuqiang mother–child cohort study (TAWS) in China

Wang, Jie; Duan, Yifan; Jian-jun, Yang; Li, Jun; Li, Fang; Zhou, Pinjiao; Liu, Changqing; Zhao, Yongli; Gu, Xuyang; Yuan, Changzheng; Yin, Shan; Yang, Zhenyu; Lai, Jianghua

doi:10.1136/bmjopen-2022-060868

Cited by 6 publications

(3 citation statements)

References 27 publications

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“…The data of this study was from the Taicang site in the Taicang and Wuqiang cohort study (TAWS) (Wang et al, 2022 ). We recruited pregnant women in early pregnancy (less than 14 weeks of gestation), followed them up throughout the pregnancy and continued to follow them and their children until 3 years postpartum.…”

Section: Methodsmentioning

confidence: 99%

Trajectory of gestational weight gain is related to birthweight: The TAWS cohort study in China

Wang,

Li,

Yang

et al. 2024

Maternal & Child Nutrition

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Few studies have reported the timing and amount of gestational weight gain (GWG) to prevent large‐for‐gestational‐age (LGA) or small‐for‐gestational‐age (SGA). This study aimed to evaluate the association of GWG velocity in each trimester with LGA or SGA based on data from the Taicang and Wuqiang cohort study (TAWS, n = 2008). We used a linear mixed model to evaluate the association of trimester‐specific GWG velocity with birthweight categories and stratified by prepregnancy body mass index category and parity. For normal‐weight pregnant women, mothers with LGA births had higher GWG velocities than mothers with appropriate‐for‐gestational‐age (AGA) births in the first trimester (0.108 vs. 0.031 kg/week, p < 0.01), second trimester (0.755 vs. 0.631 kg/week, p < 0.01) and third trimester (0.664 vs. 0.594 kg/week, p < 0.01); in contrast, mothers with SGA births had lower GWG velocities than mothers with AGA births in the second trimester (0.528 vs. 0.631 kg/week, p < 0.01) and third trimester (0.541 vs. 0.594 kg/week, p < 0.01). For normal‐weight pregnant women with AGA births, multiparous women had lower GWG velocities than primiparous women in the second (0.602 vs. 0.643 kg/week, p < 0.01) and third trimesters (0.553 vs. 0.606 kg/week, p < 0.01). Therefore, for normal‐weight women, LGA prevention would begin in early pregnancy and continue until delivery and the second and third trimesters may be critical periods for preventing SGA; in addition, among normal‐weight pregnant women with AGA births, multiparous women tend to have lower weight gain velocities than primiparous women.

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Section: Methodsmentioning

confidence: 99%

Trajectory of gestational weight gain is related to birthweight: The TAWS cohort study in China

Wang,

Li,

Yang

et al. 2024

Maternal & Child Nutrition

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“…A prospective maternal and child nutrition and health cohort in China was carried out in Wuqiang, China [ 29 ]. All pregnant women were recruited in the cohort during Jun 2016 to Oct 2018 at prenatal care center and were followed through delivery in the current study.…”

Section: Methodsmentioning

confidence: 99%

Relationships between Maternal Gene Polymorphisms in One Carbon Metabolism and Adverse Pregnancy Outcomes: A Prospective Mother and Child Cohort Study in China

et al. 2022

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Background: To investigate relationships between five single nucleotide polymorphisms (SNP) in four maternal genes involved in one carbon metabolism and adverse pregnancy outcomes, including preterm birth (PTB), low birth weight (LBW), and small-for-gestational-age (SGA). Methods: This was a prospective mother and child cohort study in Wuqiang, China. Pregnant women (n = 939) were recruited from Jun 2016 to Oct 2018. Pregnancy outcomes (PTB, LBW, and SGA) were extracted from medical records and other information including age at childbearing, maternal education level, gravidity, parity, pre-pregnancy weight and height was collected by using a structured questionnaire. The maternal serum folate concentration was measured by using Abbott Architect i2000SR chemiluminescence analyzer in the first prenatal care visit. DNA genotyping of methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C, methionine synthase reductase (MTRR) A66G, methionine synthase (MTR) A2756G, and thymidylate synthetase (TYMS) rs3819102 was processed by Sequenom MassARRAY iPLEX Platform. Univariate and multivariate logistics regression analysis were used to test the relationships between 5 SNPs and PTB, LBW, SGA. Results: Totally, 849 dyads of women and infants were included in the analysis. The prevalence of PTD, LBW, and SGA were 3.76%, 1.58%, and 5.31% respectively. The homozygote frequencies of MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G, and TYMS rs3819102 were 44.2%, 1.4%, 6.7%, 1.3%, and 3.2%, and the alt allele frequencies were 66.1%, 10.8%, 24.9%, 10.5%, and 20.5% respectively. The average serum folate concentration was 11.95 ng/mL and the folate deficiency rate was 0.47%. There were no significant associations between MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G, TYMS rs3819102 alleles and PTD, LBW, SGA (p > 0.05). Conclusions: In the population with adequate folate status and low prevalence of adverse pregnancy outcomes, MTHFR C677T, MTHFR A1298C, MTRR A66G, MTR A2756G, TYMS rs3819102 alleles may not be related to PTD, LBW, and SGA.

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“…This is a case-control study. A prospective maternal and child nutrition and health cohort in China was selected in Wuqiang, China [23]. Since parity and fetal gender are factors that may affect amino acid levels in maternal and cord sera [24,25], a frequency matching method was adopted to select 39 macrosomia infants (BW ≥ 4000 g) and 39 normal birth weight infants (BW between 2500 g and 3999 g) and their mothers from this cohort.…”

Section: Study Participantsmentioning

confidence: 99%

The Association between Macrosomia and Amino Acids’ Levels in Maternal and Cord Sera: A Case-Control Study

et al. 2023

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This study aims to explore the relationship between macrosomia and amino acids in maternal and cord sera. Methods: In the case-control study, 78 pairs of mothers and newborns were recruited from December 2016 to November 2019. Participants were divided into the macrosomia group (BW ≥ 4000 g, n = 39) and the control group (BW between 2500 g and 3999 g, n = 39) according to the birth weight (BW) of newborns. Maternal vein blood samples were collected before delivery and cord vein blood samples were collected after birth. The levels of amino acids in maternal and cord sera were measured by liquid chromatography and mass spectrometry (LC-MS/MS) in the year 2021. The difference in amino acid levels in maternal and cord sera between the two groups was compared, and the contribution of each amino acid to the difference between the two groups was analyzed. Unconditional logistic regression analysis was used to test the relationship between macrosomia and amino acids. Results: In maternal serum during the antepartum, the levels of asparagine, glutamine, methionine, alanine, and threonine in the macrosomia group were higher but arginine was lower than that in the control group (p < 0.05). In cord serum, the levels of lysine, histidine, phenylalanine, arginine, tryptophan, valine, isoleucine, glutamate, tyrosine, and total essential amino acid (EAA) in the macrosomia group were lower while glutamine was higher than that in the control group (p < 0.05). The ratios of EAA, valine, threonine, methionine, tryptophan, and alanine in maternal serum to those in cord serum were higher, while the ratio of glutamine was lower in the macrosomia group (p < 0.05). Arginine and threonine in maternal serum and glutamate, glutamine, and histidine in cord serum were associated with macrosomia (p < 0.05). Conclusion: Most of the amino acid levels in the maternal sera of the macrosomia group are higher than those in the control group, while most of the amino acids’ levels in the cord sera of the macrosomia group are lower than those in the control group. The ratios of some amino acids in maternal serum to those in cord serum were different between the two groups. Arginine and threonine in maternal serum and glutamate, glutamine, and histidine in cord serum are closely related to macrosomia.

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Cohort profile: the Taicang and Wuqiang mother–child cohort study (TAWS) in China

Cited by 6 publications

References 27 publications

Trajectory of gestational weight gain is related to birthweight: The TAWS cohort study in China

Trajectory of gestational weight gain is related to birthweight: The TAWS cohort study in China

Relationships between Maternal Gene Polymorphisms in One Carbon Metabolism and Adverse Pregnancy Outcomes: A Prospective Mother and Child Cohort Study in China

The Association between Macrosomia and Amino Acids’ Levels in Maternal and Cord Sera: A Case-Control Study

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