Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children

Dodoo, Daniel; Aikins, Anastasia Rosebud; Kusi, Kwadwo Asamoah; Lamptey, Helena; Remarque, Ed; Milligan, Paul; Bosomprah, Samuel; Chilengi, Roma; Osei, Yaa Difie; Akanmori, Bartholomew D.; Theisen, Michael

doi:10.1186/1475-2875-7-142

Cited by 127 publications

(142 citation statements)

References 55 publications

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“…Antibody level increases with age and Pf carriage. Similar results were found previously [24][25][26][27]. Seroprevalence of anti-MSP1 _42 and anti-AMA1 antibodies increase with age.…”

Section: Smc Area (N=464) Control Area (N=275) P Valuesupporting

confidence: 91%

Effect of Seasonal Malaria Chemoprevention (SMC) with SulfadoxinePyrimethamine (SP) and Amodiaquine (AQ) on the Acquisition of antiAMA1 and anti-MSP1_42 Antibodies among Children under 10 Years Living in the Southern part of Senegal (Velingara)

Sylla¹,

Tine²,

Sow³

et al. 2017

Malaria Contr Elimination

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“…Antibody level increases with age and Pf carriage. Similar results were found previously [24][25][26][27]. Seroprevalence of anti-MSP1 _42 and anti-AMA1 antibodies increase with age.…”

Section: Smc Area (N=464) Control Area (N=275) P Valuesupporting

confidence: 91%

Effect of Seasonal Malaria Chemoprevention (SMC) with SulfadoxinePyrimethamine (SP) and Amodiaquine (AQ) on the Acquisition of antiAMA1 and anti-MSP1_42 Antibodies among Children under 10 Years Living in the Southern part of Senegal (Velingara)

Sylla¹,

Tine²,

Sow³

et al. 2017

Malaria Contr Elimination

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“…Although in our current study, age influenced IgM levels significantly, Dodoo et al 2008, showed an increase in IgG with age. [50] Ladeia-Andrade et al 2009, suggested an increasing malaria infection rate with increasing age, and induction of a significant anti parasite immunity amongst native Amazonians in Brazil. [51] Some studies have shown a negative correlation between IgM levels parasitemia levels.…”

Section: Discussioncontrasting

confidence: 77%

“…[55] Multivalent malaria vaccine development offer a better chance towards an efficacious malaria vaccine compared to monovalent vaccine. [50] Antibody levels against the four vaccine candidates were significant suggesting that an ideal malaria vaccine should target more than one antigen.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of specific antibody responses to selected malaria vaccine candidates in Zimbabwean children

Marume

Nyandoro

Mutingwende

et al. 2015

Clinical Nursing Studies

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Introduction: There is high malaria related morbidity and mortality amongst infants and children in malaria endemic areas. An In-depth understanding of protective immunity correlates enables the long due necessary development of an effective malaria vaccine. This study aimed at evaluating antibody responses to apical membrane antigen 1 (AMA 1) that helps P falciparum entry into red blood cells, Glutamate rich protein (GLURP), an antigen expressed in the whole life cycle of the malaria causing pathogen, merozoite surface protein-1 (MSP 1) coding for a major antigen in the asexual stage of P falciparum and merozoite surface protein 3 (MSP 3), a polymorphic blood stage malaria antigen in Zimbabwean children living in malaria endemic areas. Methods: We characterized humoral immune responses to malaria vaccine candidates in a two year longitudinal survey among 136 children (6-16 years) from Burma and Kariba in Zimbabwe. Blood samples were collected and analyzed for malaria parasites, plasma and antibody titers against malaria vaccine candidates [MSP1, MSP3, GLURP, AMA] by ELISA technique. The blood samples were also checked for potential confounders like anemia, bilharzia and HIV sero-status using the ELISA technique. Results: Ig levels were significantly different (p < .0001) across the three time points, and against the different candidates (p < .0001). MSP3 had the highest (13,552.2) and GLURP the least (4,741.6) IgM titers. However, IgG, IgG1, IgG3 and IgG4 levels were highest against AMA compared to other vaccine candidates, 3) and anti-GLURP IgG4 (58.7)]. Anemia burden was about 44% at baseline with a threefold decrease (-16%) over the 12 month follow up. Conclusions: This study highlights the need for robust evaluation of several malaria vaccine candidates in combination to understand correlates of protective immunity as suggested by the significant antibody levels against the four vaccine candidates. Longer follow up periods are needed to assess the impact of continuous malaria exposure on host immune responses. Multivalent malaria vaccine development offer a better chance towards an efficacious malaria vaccine compared to monovalent vaccine. Antibody levels against the four vaccine candidates were significant suggesting that an ideal malaria vaccine should target more than one antigen.

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“…These results are also buttressed by independent experiments where the extent of correlation between antibody levels in a healthy state and during concurrent infection seemed to be antigen‐specific 43, 77. Polymorphic GPI‐anchored antigens [such as anti‐mitochondrial antibodies (AMA)‐1] often induced relatively higher antibody levels compared with conserved antigens (such as the Rhs) 43, 78, 79, 80. Responses also seemed site‐specific, with different levels observed for the same antigen in different sites 42, 43.…”

Section: Antibodies and Protection: What We Have Learnt So Farmentioning

confidence: 99%

Evaluating antidisease immunity to malaria and implications for vaccine design

Ademolue

Awandare

2017

Immunology

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SummaryImmunity to malaria could be categorized broadly as antiparasite or antidisease immunity. While most vaccine research efforts have focused on antiparasite immunity, the evidence from endemic populations suggest that antidisease immunity is an important component of natural immunity to malaria. The processes that mediate antidisease immunity have, however, attracted little to no attention, and most interests have been directed towards the antibody responses. This review evaluates the evidence for antidisease immunity in endemic areas and discusses the possible mechanisms responsible for it. Given the key role that inflammation plays in the pathogenesis of malaria, regulation of the inflammatory response appears to be a major mechanism for antidisease immunity in naturally exposed individuals.

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Cohort study of the association of antibody levels to AMA1, MSP119, MSP3 and GLURP with protection from clinical malaria in Ghanaian children

Cited by 127 publications

References 55 publications

Effect of Seasonal Malaria Chemoprevention (SMC) with SulfadoxinePyrimethamine (SP) and Amodiaquine (AQ) on the Acquisition of antiAMA1 and anti-MSP1_42 Antibodies among Children under 10 Years Living in the Southern part of Senegal (Velingara)

Effect of Seasonal Malaria Chemoprevention (SMC) with SulfadoxinePyrimethamine (SP) and Amodiaquine (AQ) on the Acquisition of antiAMA1 and anti-MSP1_42 Antibodies among Children under 10 Years Living in the Southern part of Senegal (Velingara)

Evaluation of specific antibody responses to selected malaria vaccine candidates in Zimbabwean children

Evaluating antidisease immunity to malaria and implications for vaccine design

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