Cohorte RIS de pacientes con infección por VIH sin tratamiento antirretroviral previo (CoRIS): metodología y primeros resultados

Caro-Murillo, Ana María; Castilla, Jesús; Pérez-Hoyos, Santiago; Miró, José M.; Podzamczer, Daniel; Rubio, Rafael; Riera, Melchor; Viciana, Pompeyo; Aldeguer, José López; Iribarren, José Antonio; Santos-Gil, Ignacio de los; Gómez-Sirvent, Juan Luís; Berenguer, Juan; Gutiérrez, Félix; Saumoy, María; Segura, Ferrán; Soriano, Vincent; Peña, Alejandro; Pulido, Federico; Oteo, José A.; Leal, M. J.; Casabona, Jordi; Amo, Julia del; Moreno, Santiago

doi:10.1157/13096749

Cited by 110 publications

(37 citation statements)

References 22 publications

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“…CoRIS is a prospective, open and multicenter cohort of patients newly diagnosed with HIV who are over 13 years of age and naïve to antiretroviral treatment at cohort entry [9,10]. Of the 28 centers participating in CoRIS, nine hospitals and one sexually transmitted disease clinic in each of eight cities (Madrid, Valencia, Logroño, Santa Cruz de Tenerife, Elche, Alicante, Murcia, and Donostia) from six Autonomous Communities of Spain participated in this project (see Additional file 1).…”

Section: Methodsmentioning

confidence: 99%

Reproductive desire in women with HIV infection in Spain, associated factors and motivations: a mixed-method study

Hernando

Alejos

Álvarez

et al. 2014

BMC Pregnancy Childbirth

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BackgroundAntiretroviral therapy has created new expectations in the possibilities of procreation for persons living with HIV. Our objectives were to evaluate reproductive desire and to analyze the associated sociodemographic and clinical factors in HIV-infected women in the Spanish AIDS Research Network Cohort (CoRIS).MethodsA mixed qualitative-quantitative approach was designed. Women of reproductive age (18–45) included in CoRIS were interviewed by phone, and data were collected between November 2010 and June 2012 using a specifically designed questionnaire. Reproductive desire was defined as having a desire to be pregnant at present or having unprotected sex with the purpose of having children or wanting to have children in the near future.ResultsOverall, 134 women were interviewed. Median age was 36 years (IQR 31–41), 55% were Spanish, and 35% were unemployed. 84% had been infected with HIV through unprotected sex, with a median time since diagnosis of 4.5 years (IQR 2.9-6.9). Reproductive desire was found in 49% of women and was associated with: 1) Age (women under 30 had higher reproductive desire than those aged 30–39; OR = 4.5, 95% CI 1.4-14.3); 2) having no children vs. already having children (OR = 3.2; 1.3-7.7 3); Being an immigrant (OR = 2.2; 1.0-5.0); and 4) Not receiving antiretroviral treatment (OR = 3.6; 1.1-12.1). The main reasons for wanting children were related to liking children and wanting to form a family. Reasons for not having children were HIV infection, older age and having children already. Half of the women had sought or received information about how to have a safe pregnancy, 87% had disclosed their serostatus to their family circle, and 39% reported having experienced discrimination due to HIV infection.ConclusionsThe HIV-infected women interviewed in CoRIS have a high desire for children, and the factors associated with this desire are not fundamentally different from those of women in the general population. Maternity may even help them face a situation they still consider stigmatized and prefer not to disclose. Health-care protocols for handling HIV-positive women should incorporate specific interventions on sexual and reproductive health to help them fulfill their procreation desire and experience safe pregnancies.

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Section: Methodsmentioning

confidence: 99%

Reproductive desire in women with HIV infection in Spain, associated factors and motivations: a mixed-method study

Hernando

Alejos

Álvarez

et al. 2014

BMC Pregnancy Childbirth

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“…24 Approval has been obtained from all Hospitals Ethics Committees and all patients have signed an informed consent. 25 CoRIS is a joint activity of the Research Network of Excellence (AIDS research network, RIS) that incorporates basic scientists, immunologists, virologists, clinicians, epidemiologists, and statisticians. A total of 27 hospitals from 13 of the 17 Autonomous Regions of the country participate in CoRIS.…”

Section: Methodsmentioning

confidence: 99%

Definition of Advanced Age in HIV Infection: Looking for an Age Cut-Off

Blanco

Jarrín

Vallejo

et al. 2012

AIDS Research and Human Retroviruses

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The age of 50 has been considered as a cut-off to discriminate older subjects within HIV-infected people according to the Centers for Disease Control and Prevention (CDC). However, the International AIDS Society (IAS) mentions 60 years of age and the Department of Health and Human Services (DHHS) makes no consideration. We aimed to establish an age cut-off that could differentiate response to highly active antiretroviral therapy (HAART) and, therefore, help to define advanced age in HIV-infected patients. CoRIS is an open, prospective, multicenter cohort of HIV adults naive to HAART at entry ( January 2004 to October 2009). Survival, immunological response (IR) (CD4 increase of more than 100 cell/ml), and virological response (VR) (HIV RNA less than 50 copies/ml) were compared among 5-year age intervals at start of HAART using Cox proportional hazards models, stratified by hospital and adjusted for potential confounders. Among 5514 patients, 2726 began HAART. During follow-up, 2164 (79.4%) patients experienced an IR, 1686 (61.8%) a VR, and 54 (1.9%) died. Compared with patients aged < 25 years at start of HAART, those aged 50-54, 55-59, 60-64, 65-59, and 70 or older were 32% (aHR: 0.68, 95% CI: 0.52-0.87), 29% (aHR: 0.71, 95% CI: 0.53-0.96), 34% (aHR: 0.66, 95% CI: 0.46-0.95), 39% (aHR: 0.61, 95% CI: 0.37-1.00), and 43% (aHR: 0.57, 95% CI: 0.31-1.04) less likely to experience an IR. The VR was similar across all age groups. Finally, patients aged 50-59 showed a 3-fold increase (aHR: 3.58; 95% CI: 1.07-11.99) in their risk of death compared to those aged < 30 years. In HIV infection, patients aged ‡ 50 years have a poorer immunological response to HAART and a poorer survival. This age could be used to define medically advanced age in HIV-infected people.

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“…El último informe de la Organización Mundial de la Salud (OMS) 2 en 2013 confirma un ligero descenso de las nuevas infecciones por el VIH, pero el número total de personas afectadas muestra un continuo incremento. La tasa de nuevos diagnósticos de infección por el VIH en España es superior a la media europea (8,5/100.000 versus 5,9/100.000) 3 . En España, la epidemiología de la infección VIH ha sufrido cambios notorios.…”

Section: Introductionunclassified

“…Entre los años anteriores y posteriores al año 2000, otro cambio importante fue el impacto de la inmigración. Aumentó la proporción de inmigrantes entre los nuevos casos diagnosticados [5][6][7][8] debido a la disminución del número de casos en autóctonos junto con el incremento de inmigrantes procedentes de áreas con altas prevalencias del VIH 9 .…”

Section: Introductionunclassified

Infección VIH/Sida y otras infecciones de transmisión sexual en la población inmigrante en España: revisión bibliográfica

Rovirola

Ortiz-Barreda

Montemayor

et al. 2014

Rev. Esp. Salud Publica

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RESUMENFundamentos: Los flujos migratorios tienen la capacidad de dispersar agentes infecciosos y alterar las epidemiologías locales. El objetivo del estudio es describir las características socio-epidemiológicas, clínicas y de microbiología/epidemiología molecular de la infección VIH/Sida en la población inmigrada.. Métodos:Revisión de la literatura científica mediante la metodología de Scoping Review. Se realizó una búsqueda bibliográfica en las bases de datos Medline y MEDES. Se seleccionaron artículos originales realizados en España y publicados entre 1998-2012, en los que participara población procedente de América Latina, África subsahariana, Norte de África, Asia y Europa del Este.Resultados: Se seleccionaron 41 artículos. La población más estudiada fue la de América Latina (48,8%). Se observaron prevalencias mayores de VIH que en autóctonos en los hombres que tienen sexo con hombresde América Latina (18,1%), travestis y transexuales trabajadores del sexo de América Latina (23,3%), mujeres gestantes (0,9%) y hombres y mujeres de África Subsahariana (9,1% y 7,5%). Las conductas de riesgo fueron diferentes en función del país de origen y del sexo. El retraso diagnóstico llegó al 43% de las infecciones VIH, hallándose mayor prevalencia en inmigrantes de África subsahariana, que mostraron retraso diagnóstico en el 41% y resistencias al tratamiento anti-retroviral en el 13%. Las mujeres inmigrantes presentaron más pérdidas de seguimiento, peor respuesta inmunológica al TARV y menor tiempo de fracaso terapéutico.Conclusiones: La mayor prevalencia de VIH la presentan los sujetos procedentes de África subsahariana y los hombres que tienen sexo con hombres y travestis y transexuales trabajadores del sexo de América Latina. También las mujeres gestantes. El retraso diagnóstico y las resistencias al tratamiento son más frecuentes en sujetos de África Subsahariana. Las mujeres inmigrantes respondieron peor al tratamiento antiretroviral. Background: Migration flows have the ability to disperse infectious agents and alter local epidemiologies. The aim of the study is to describe the socio-epidemiological, clinical and microbiology / molecular epidemiology of HIV / AIDS infection in the immigrant population.

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Cohorte RIS de pacientes con infección por VIH sin tratamiento antirretroviral previo (CoRIS): metodología y primeros resultados

Cited by 110 publications

References 22 publications

Reproductive desire in women with HIV infection in Spain, associated factors and motivations: a mixed-method study

Reproductive desire in women with HIV infection in Spain, associated factors and motivations: a mixed-method study

Definition of Advanced Age in HIV Infection: Looking for an Age Cut-Off

Infección VIH/Sida y otras infecciones de transmisión sexual en la población inmigrante en España: revisión bibliográfica

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