2022
DOI: 10.1155/2022/7745315
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Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma

Abstract: Objective. The role of coiled-coil domain-containing protein 45 (CCDC45) in the development of hepatocellular carcinoma (HCC) has not been reported. The present study is aimed at investigating the expression and prognosis of CCDC45 in HCC and its relevance to immune infiltration. Methods. We conducted CCDC45 expression analysis using The Cancer Genome Atlas (TCGA) tumor database, the Human Protein Atlas (HPA) database, and the Tumor Immunological Evaluation Resource (TIMER). We used the University of Alabama a… Show more

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“…INSRR encodes the insulin receptor related receptor which is involved in the transmembrane receptor protein tyrosine kinase activity, actin cytoskeleton reorganization, and the protein autophosphorylation, and has an important role in the alkaline pH-dependent activation mechanism ( 43 ). CEP95 encodes the centrosomal protein 95 and belongs to the family of proteins containing coiled-coil domains (CCDCs), which are involved in several functions in cell growth and development, such as regulation of gene expression ( 44 ). To date, no mutations in either INSRR or CEP95 have been linked to eye diseases, and further studies are needed to confirm the role of these genes in cataract etiology and determine their precise role in cataract susceptibility.…”
Section: Discussionmentioning
confidence: 99%
“…INSRR encodes the insulin receptor related receptor which is involved in the transmembrane receptor protein tyrosine kinase activity, actin cytoskeleton reorganization, and the protein autophosphorylation, and has an important role in the alkaline pH-dependent activation mechanism ( 43 ). CEP95 encodes the centrosomal protein 95 and belongs to the family of proteins containing coiled-coil domains (CCDCs), which are involved in several functions in cell growth and development, such as regulation of gene expression ( 44 ). To date, no mutations in either INSRR or CEP95 have been linked to eye diseases, and further studies are needed to confirm the role of these genes in cataract etiology and determine their precise role in cataract susceptibility.…”
Section: Discussionmentioning
confidence: 99%