Nowadays, the transradial approach is increasingly used for performing percutaneous coronary interventions and is preferred over the transfemoral approach. In the latest European Society of Cardiology guidelines (2017) for management of acute myocardial infarction in patients presenting with ST-segment elevation, the transradial approach is recommended over the transfemoral one if performed by an experienced radial operator (MATRIX study). Transradial procedure failures may be related to puncture failure, artery spasm, or to anatomical variations that require specific catheter handling or changing with a contralateral or transfemoral approach. Herein we report a failure of transradial heart catheterization due to brachial artery coiling.