Coincidence of cutaneous blastic plasmacytoid dendritic cell neoplasm and myelodysplastic syndrome derived from clonal hematopoiesis

Clinical, Histopathological and Molecular Spectrum of Cutaneous Lesions in Myelodysplastic Syndrome and Myeloproliferative Neoplasms (MDS/MPN): An Integrative Review

“…They performed targeted NGS and copy number analyses (CNA) that revealed that both originated from the same clonal origin which subsequently evolved into BPDCN by acquiring multiple CNVs. The higher VAFs of the common mutations compared to the other mutations suggest that the genetic events occurred in the early phase and could have originated from CHIP [65].…”

“…Case reports on the common clonal origins of BPDCN and MDS are rare. Recently, Yamada et al have reported a patient diagnosed with BPDCN limited to the skin and MDS with increased blasts 1 (MDS-IB1) in the BM [65]. They performed targeted NGS and copy number analyses (CNA) that revealed that both originated from the same clonal origin which subsequently evolved into BPDCN by acquiring multiple CNVs.…”

“…The following supporting information can be downloaded at: https: //www.mdpi.com/article/10.3390/cancers15245888/s1, Table S1: MDS/MPN related dermatoses with indolent clinical course with main clinical, epidemiological, immunophenotypic and genetic features; Table S2: Cutaneous processes related to either MDS/MPN and aggressive clinical behavior with main with main clinical, epidemiological, immunophenotypic and genetic features. References [6,7,12,13,15,16,24,25,29,30,35,[37][38][39][45][46][47][51][52][53][56][57][58][64][65][66][67][68][69][70][71][72][73]75,77,79] are cited in the supplementary materials.…”