The possibility of using astrophysical observations of rotational transitions in the methanol molecule to measure, or constrain temporal and spatial variations in the proton-to-electron mass ratio (µ) has recently been investigated by several groups. Here we outline some of the practical considerations of making such observations, including both the instrumental and astrophysical limitations which exist at present. This leads us to conclude that such observations are unlikely to be able to improve evidence either for, or against the presence of variations in the proton-to-electron mass ratio by more than an order of magnitude beyond current limits.PACS numbers: 06.20. Jr, 98.38.Er, 98.58.Ec The possibility of using astrophysical observations of rotational transitions in the methanol molecule to measure, or constrain temporal and spatial variations in the proton-to-electron mass ratio (µ) has recently been suggested by several groups [1,2]. The first attempts to use astronomical observations of methanol masers to constrain µ within the Milky Way show that |∆µ/µ| < 28 × 10 −9 [2].The hindered internal rotation exhibited by methanol produces the degeneracy which makes the different rotational transitions particularly sensitive to the protonto-electron mass ratio [1]. It also leads to the rich rotational and vibrational spectrum, which due to quantum mechanical selection rules produces a large number of centimetre and millimetre maser transitions in interstellar space. The strongest and most common of these is the 5 1 → 6 0 A + transition which has a rest frequency of approximately 6.7 GHz. It has been detected towards more than 900 sites of high-mass star formation in the Milky Way [see for example 3, 4]. The second strongest astrophysical transition of methanol is from the 2 0 → 3 −1 E transition which has a rest frequency of approximately 12.2 GHz, and is observed towards 43% of those sources showing 6.7 GHz emission [5]. In most methanol maser regions multiple spectral features are observed in the spectra of 6.7 or 12.2 GHz methanol masers at different Doppler shifted velocities [3,4]. The spectral features typically have near-Gaussian profiles (although spectral blending between spatially unresolved components affects most observations), and FWHM (full-width half maximum) of a few tenths of kilometers per second.The K µ coefficient measures the sensitivity of a transition to the proton-to-electron mass ratio and for the 6.7 and 12.2 GHz methanol transitions these have been calculated to be -42 and -33 respectively [1]. To improve constraints on |∆µ/µ|, beyond those already achieved [2], requires measurement of the relative Doppler shifted velocities of the different transitions to an accuracy of better than 100 ms −1 . When the 6.7 and 12.2 GHz methanol transitions exhibit peaks at the same velocity they have been demonstrated to arise from the same locations at the milliarcsecond level (corresponding to linear scales of a few AU at distances of a few kpc) [6,7]. The large number of 6.7 and 12.2 GHz methanol...