Coincidence of pachydermoperiostosis and synovitis, acne, pustulosis, hyperostosis, osteitis syndrome, a causal or casual association?

Abstract

Pachydermoperiostosis (PDP) is a rare disorder characterized by skin thickening, acropachia, and periostosis. Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome is also an orphan disease featured by different dermatological and osteoarthritic manifestations. Herein, we report the first case of an adolescent male diagnosed with both PDP and SAPHO syndrome, presenting with digital clubbing, polyarthralgia, ostealgia, pachydermia and acne on his face, chest and back. Furthermore, we distinguish the characteristics of both diseases and explore the potential pathological mechanism for this coexistence in one patient. Further investigations are needed to establish the detailed pathophysiological association of these 2 diseases.

Synovitis, acne, pustulosis, hyperostosis, osteitis syndrome with invisible organizing pneumonia: A case report

“…Synovitis, acne, pustulosis, hyperostosis, osteitis (SAPHO) syndrome, first introduced by Chamot et al in 1987, is an orphan disease featured by dermatological and osteoarthritic manifestations. 1,2 The relationship between SAPHO syndrome and lung abnormalities (such as pleural effusion, multiple pulmonary necrotic nodules and small cell lung cancer) has been discussed in previous case reports. [3][4][5] In this article, we present a case of a SAPHO patient complicated by invisible organized pneumonia (OP) and who ultimately recovered.…”