Coincidence of Thyroid Tumor and Thyroglossal Duct Remnants. Review of the Literature and Presentation of Three Cases

Astl, Jaromı́r; Dušková, J; Kraus, Jaroslav; Vlček, Petr; Kodet, Roman; Laštůvka, Petr; Betka, Jan

doi:10.1177/030089160308900316

Cited by 14 publications

(26 citation statements)

References 23 publications

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“…13 The cause is obscure, although previous irradiation could be a possible risk factor, as indicated in some literature 2,12 Also the possibility of thyroid origin and spread from a primary site have been suggested and this obviously has important implications for the therapeutic approach in these cases. 14 The prognosis of PTC is excellent when it occurs in TDC. 2,9,13 Thyroglossal duct carcinoma may be clinically indistinguishable from a benign TDC, therefore necessitating that all TDC should be studied by FNA for accurate characterization and timely intervention.…”

Section: Discussionmentioning

confidence: 99%

Thyroglossal duct cyst: A cytopathologic study of 26 cases

et al. 2005

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Thyroglossal duct cyst (TDC), or embryologic remnants of thyroid gland, is a common congenital anomaly. TDC may cause a midline neck mass, which occasionally may become infected, and rarely gives rise to carcinoma. As a number of other nonneoplastic and neoplastic lesions can cause cystic masses in the neck, we explored the role of fine-needle aspiration (FNA) in making a preoperative diagnosis of TDC for a more accurate and timely clinical intervention. Twenty-six cases of TDC were identified from the cytopathology files of The Johns Hopkins Hospital in a 15-yr period (1990-2004). Material was obtained by FNA with or without radiologic (ultrasound) guidance. Smears were air-dried and stained with Diff-Quik, or wet-fixed and stained with Papanicolaou stain. Cytomorphologic characteristics were serially analyzed. Follow-up (tissue resection [n = 9] and clinical charts [n = 17]) was reviewed in all cases. Patients ranged in age from 8 to 83 yr (mean age, 55) with M:F ratio of 1.4:1. The size of the cyst ranged from 1.2 to 5 cm (mean 2.5 cm), as evaluated on radiological scans. The most common clinical presentation was a non-tender, mobile neck mass, which was painful on swallowing. Follow-up confirmed TDC in 18/26 cases (69%), whereas 8/26 cases resulted in various other benign lesions. During the same time period, 11/18 (61%) cases of surgically resected TDC were missed on prior FNA. Therefore, FNA showed a diagnostic sensitivity of 62% and a positive predictive value (PPV) of 69% for the diagnosis of TDC. The cytomorphologic features of TDC included the following: colloid (thick and fragmented, thin and watery, or mucinous), macrophages, lymphocytes, or predominantly neutrophils. The epithelium was ciliated columnar, metaplastic squamous or of mature squamous type. Thyroid epithelium was only rarely present (11%). FNA is only moderately sensitive for a preoperative evaluation of TDC. Cytomorphologic features are not unique; however, in the right clinicoradiologic setting should lead to an accurate diagnosis. Abundant colloid, most often with ciliated columnar epithelium, is the predominant cytopathologic finding. Thyroid epithelium is rarely identified. Differential diagnosis involves branchial cleft cyst, lymphoepithelial cyst, thyroid gland lesions, and lymphadenopathy (of various etiologies).

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Section: Discussionmentioning

confidence: 99%

Thyroglossal duct cyst: A cytopathologic study of 26 cases

et al. 2005

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“…3 Aspiration of a TDC usually reveals mucoid material, a proteinaceous background, mature squamous cells and inflammatory cells. Columnar epithelial cells may also be present.…”

Section: Discussionmentioning

confidence: 99%

“…Columnar epithelial cells may also be present. 3,4 This benign congenital cyst is common, estimated to occur in 7% of the adult population, but malignancy arising in the cyst wall is rare. 1,[3][4][5] As noted by Bardales and colleagues, approximately 150 cases of carcinoma arising in a TDC have been reported.…”

Section: Discussionmentioning

confidence: 99%

“…Carcinoma of thyroglossal duct remnants is very rare. [1][2][3] Approximately 170 TDC carcinoma cases have been reported in the literature worldwide. 3 At least 85% have been papillary carcinoma (PC).…”

mentioning

confidence: 99%

“…[1][2][3] Approximately 170 TDC carcinoma cases have been reported in the literature worldwide. 3 At least 85% have been papillary carcinoma (PC). 1,2,4 Even rarer are reports of these cases diagnosed by fine needle aspiration cytology (FNAC).…”

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confidence: 99%

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Tall Cell Variant of Papillary Carcinoma Arising from a Thyroglossal Cyst

Köybaşıoğlu¹,

Şimşek²,

Önal³

2006

Acta Cytologica

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Fine‐needle aspiration diagnosis of secondary malignant tumors of the thyroid gland: A single‐institution experience of 17 cases

Zhang,

Lei,

Chen

et al. 2024

Diagnostic Cytopathology

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BackgroundFine‐needle aspiration (FNA) is the most commonly used preoperative pathological diagnostic tool for thyroid tumors. Secondary malignant tumors of the thyroid gland account for less than 3% of all thyroid malignancies. The aim of this study was to investigate the types and cytopathological features of secondary thyroid tumors, evaluate diagnostic pitfalls in FNA.MethodsCases of secondary thyroid tumors diagnosed in the Department of Pathology of Shaanxi Provincial People's Hospital were collected, and their clinical data, cytologic features, immunohistochemical results, and histopathological diagnoses were summarized.ResultsThe study included 17 cases (8 males and 9 females) with a mean age of 60.4 ± 9.4 years (range, 45–83 years). Six cases had a known history of primary malignancy prior to FNA aspiration diagnosis. The most common organs of origin were the lungs (5 cases, 3 adenocarcinoma, and 2 small‐cell carcinoma) and esophagus (5 cases, 3 squamous‐cell carcinoma, 1 adenocarcinoma, and 1 small‐cell carcinoma). The next most common was squamous‐cell carcinoma of the larynx (3 cases), and gastric tumor (2 cases), including 1 lymphoma and 1 adenocarcinoma. Cell blocks and immunohistochemistry were performed in 12 of these cases. Comparison of the impact of positive history and IHC availability on the accuracy of pathologic diagnosis showed that both were statistically significant.ConclusionFNA is an effective means of diagnosing secondary malignancies of the thyroid, in which knowledge of the patient's history of malignancy is essential, and the use of cell blocks and immunohistochemistry helps to clarify the pathological diagnosis.

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Coincidence of Thyroid Tumor and Thyroglossal Duct Remnants. Review of the Literature and Presentation of Three Cases

Cited by 14 publications

References 23 publications

Thyroglossal duct cyst: A cytopathologic study of 26 cases

Thyroglossal duct cyst: A cytopathologic study of 26 cases

Tall Cell Variant of Papillary Carcinoma Arising from a Thyroglossal Cyst

Fine‐needle aspiration diagnosis of secondary malignant tumors of the thyroid gland: A single‐institution experience of 17 cases

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