Coincidental aneurysms with tumours of pituitary origin.

Abstract

SUMMARY Angiographic studies on 150 pituitary adenomas and 33 craniopharyngiomas presenting for surgical treatment are reviewed. Eleven incidental silent aneurysms (four arising from the intracavernous and four from the supraclinoid carotid artery, and three from the anterior cerebral artery complex) are shown. Intracavernous aneurysms were also present in two acromegalic patients who had been treated previously with yttrium implantation. Although encasement of vessels by these tumours is unusual, the relevance of vascular abnormalities to surgical treatment is sufficient to justify routine magnification angiography.

Early Development and Rupture of De Novo Aneurysm. Case Report.

“…The coexistence of aneurysms with sellar neoplasms has an incidence of 6%, or 11 aneurysms among 150 pituitary adenomas and 33 craniopharyngiomas. 9) The annual incidence of de novo aneurysm is calculated to be 100 per 100,000 patients with known aneurysm. 12) De novo aneurysms commonly occur in the 3rd and 4th decades of life at an interval of 3-20 years.…”

Hypothalamic Hamartoma Associated With Anterior Paraclinoid Aneurysm of the Internal Carotid Artery-Case Report-

“…Location of the tumor at the base of the skull may also have some influence on the adjacent vessels. 9,10,16) Mechanical, microcirculatory, and hormonal factors have all been proposed in attempts to explain the association. Growth hormone might be responsible for the formation of intracranial aneurysm by causing atherosclerotic lesions of the blood vessels and changes in the composition of the collagen in the vessel wall.…”

“…1,9,22) Meningiomas accounted for 29%, gliomas 28%, and pituitary adenomas 21% in a series of 116 cases of the intracranial aneurysm-tumor association. 16) Local circulatory changes caused by the tumors might have induced the aneurysms.…”

Intrasellar internal carotid aneurysm coexisting with GH-secreting pituitary adenoma in an acromegalic patient

“…The prevalence of the coexistence of pituitary adenoma and cerebral aneurysm is higher then that with other benign brain tumors in the general population 5 . Approximately 50% of these patients have acromegaly 1,3,[5][6][7][8] , suggesting that high GH and IGF-1 levels or their biological effects might be implicated in the aneurysm's genesis. High IGF-1 induces artery dilation 8 , atherosclerotic and degenerative changes of the artery wall 8,9 , tumor invasion and tumor-directed neovessels 9 .…”

“…The coexistence of pituitary adenoma and cerebral aneurysm is rare, although its prevalence is higher then would be expected in general population [1][2][3][4][5] . We report on an extremely rare condition where growth hormone (GH) -secreting adenoma coexisted with an intrasellar internal carotid artery (ICA) aneurysm.…”