Coincidental occurance of episodic ataxia and multiple sclerosis: a case report and review of the literature

Ak, Ayşın Kısabay; Çetin, Güldeniz; Çelebi, Hamide Betül Gerik; Çam, Sırrı; Mavioğlu, Hatice

doi:10.1080/00207454.2020.1835896

Cited by 3 publications

(1 citation statement)

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“…Episodic ataxia may also be present in demyelinating diseases [95]. A recent case report revealed a coincidental occurrence of type 2 episodic ataxia and MS in a patient with previously unidentified heterozygous mutation in the gene coding for the voltagegated calcium channel subunit alpha 1A [96]. These cases highlight the various anatomical regions that can be affected in demyelinating lesions, resulting in ataxia and the long-term disability of ataxia in patients with MS.…”

Section: ) Ataxiamentioning

confidence: 86%

Movement Disorders in Multiple Sclerosis: An Update

Ghosh

Roy

Dubey

et al. 2022

Tremor and Other Hyperkinetic Movements

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Background: Multiple sclerosis (MS), a subset of chronic primary inflammatory demyelinating disorders of the central nervous system, is closely associated with various movement disorders. These disorders may be due to MS pathophysiology or be coincidental. This review describes the full spectrum of movement disorders in MS with their possible mechanistic pathways and therapeutic modalities. Methods:The authors conducted a narrative literature review by searching for 'multiple sclerosis' and the specific movement disorder on PubMed until October 2021. Relevant articles were screened, selected, and included in the review according to groups of movement disorders. Results:The most prevalent movement disorders described in MS include restless leg syndrome, tremor, ataxia, parkinsonism, paroxysmal dyskinesias, chorea and ballism, facial myokymia, including hemifacial spasm and spastic paretic hemifacial contracture, tics, and tourettism. The anatomical basis of some of these disorders is poorly understood; however, the link between them and MS is supported by clinical and neuroimaging evidence. Treatment options are disorder-specific and often multidisciplinary, including pharmacological, surgical, and physical therapies.Discussion: Movements disorders in MS involve multiple pathophysiological processes and anatomical pathways. Since these disorders can be the presenting symptoms, they may aid in early diagnosis and managing the patient, including monitoring disease progression. Treatment of these disorders is a challenge. Further work needs to be done to understand the prevalence and the pathophysiological mechanisms responsible for movement disorders in MS.

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Section: ) Ataxiamentioning

confidence: 86%