Coinfection and circulation of chikungunya virus and dengue virus in pediatric patients in Myanmar, 2019

Tun, Mya Myat Ngwe; Kyaw, Aung Kyaw; Nabeshima, Takeshi; Dumre, Shyam Prakash; Soe, Aung Min; Nwe, Khine Mya; Myaing, Su Su; Lwin, Ei Phyu; Win, Ye Thu; Inoue, Satoshi; Takamatsu, Yuki; Urano, Takeshi; Thu, Hlaing Myat; Thant, Kyaw Zin; Htun, Zaw Than; Morita, Kouichi

doi:10.1016/j.micinf.2023.105129

Cited by 6 publications

(10 citation statements)

References 41 publications

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“…The rest could be other kinds of infections and we could not check for other causes of infection in this study. The primer used to detect chikungunya virus in this study had no cross-reactivity with ZIKV, all four serotypes of DENV, West Nile virus, Kunjin Virus, enterovirus 71, echo virus, and other alpha viruses such as Ross River virus as described in the previous studies [ 8 , 26 ].…”

Section: Discussionmentioning

confidence: 87%

“…Among seropositive cases, 80% of IgM only positive and 96.4% of IgG only positive cases were confirmed for CHIKV infection. Among the dengue-suspected pediatric patients, 35.3% were only DENV-infected, 14.9% were only CHIKV-infected, and 29.4% were coinfected with DENV and CHIKV in previous studies [ 7 , 8 ]. The rest could be other kinds of infections and we could not check for other causes of infection in this study.…”

Section: Discussionmentioning

confidence: 95%

“…DENV, Zika Virus (ZIKV), and CHIKV are endemic to Myanmar and present with similar clinical manifestations [ 9 ]. No surveillance has been performed for CHIKV infections; therefore, estimates of the overall burden of the disease, immune statuses against CHIKV infection among the population, and hospital attendant rates in Myanmar are lacking [ 7 , 8 ]. To introduce a new vaccine into the expanded immunization program, baseline data regarding these factors are crucial [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The first case of CHIKV infection in Myanmar was serologically confirmed in 1976, and the first isolate of the East Central South African (ECSA) genotype was identified during the 2010 outbreak [ 5 , 6 ]. Subsequently, CHIKV silently circulated in the region, and 9 years after the initial outbreak, a new clade of the ECSA genotype emerged that caused a large outbreak in Myanmar [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…CHIKV infection has clinical manifestations that range from asymptomatic to fatal. The clinical manifestations of dengue virus (DENV) and CHIKV infections are similar such as high fever, headache, nausea, vomiting, rashes, arthralgia, and myalgia; however, acute arthritis and rash are more prominent in CHIKV infection [ 8 , 9 , 10 ]. In addition, atypical manifestations and neurological manifestations of CHIKV have been reported [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Burden of Chikungunya Virus Infection during an Outbreak in Myanmar

Ngwe Tun,

Kyaw,

Nwe

et al. 2023

Viruses

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Chikungunya virus (CHIKV) infection is a re-emerging arboviral disease with no approved vaccine, although numerous options are in development. Before vaccine implementation, disease burden, affected age group, and hospitalization rate information should be documented. In 2019, a sizeable outbreak of the East Central South African genotype of CHIKV occurred in Myanmar, and during this period, a cross-sectional study was conducted in two regions, Mandalay and Yangon, to examine the molecular and seropositivity rate of the CHIKV infection. The participants (1124) included dengue-suspected pediatric patients, blood donors, and healthy volunteers, who were assessed using molecular assays (quantitative real-time RT-PCR), serological tests (anti-CHIKV IgM capture and IgG indirect enzyme-linked immunosorbent assays), and neutralization tests. The tests confirmed the following positivity rates: 11.3% (127/1124) for the molecular assay, 12.4% (139/1124) for the anti-CHIKV IgM Ab, 44.5% (500/1124) for the anti-CHIKV IgG Ab, and 46.3% (520/1124) for the CHIKV neutralizing Ab. The highest rate for the molecular test occurred with the dengue-suspected pediatric patients. The seroprevalence rate through natural infection was higher in the healthy volunteers and blood donors than that in the pediatric patients. The results of this study will help stakeholders determine the criteria for choosing appropriate recipients when a CHIKV vaccine is introduced in Myanmar.

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Section: Discussionmentioning

confidence: 87%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Burden of Chikungunya Virus Infection during an Outbreak in Myanmar

Ngwe Tun,

Kyaw,

Nwe

et al. 2023

Viruses

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Possible vertical transmission of Chikungunya virus infection detected in the cord blood samples from a birth cohort in Vietnam

Ngwe Tun,

Luvai,

Toizumi

et al. 2024

Journal of Infection and Public Health

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Optimization of a ternary photonic crystal biosensor for enhanced chikungunya virus detection

El Mouncharih,

Takassa,

Elfatouaki

et al. 2024

Opt. Eng.

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The chikungunya virus (CHIKV), transmitted by mosquitos, induces severe symptoms such as joint pain, headaches, and exhaustion, necessitating swift diagnosis and intervention. In this investigation, the transfer matrix method is employed to enhance virus detection using a ternary photonic crystal (PC) biosensor across normal and infected blood constituents-plasma, platelets, red blood cells, and uric acid. These components possess distinctive refractive indices crucial for the biosensor's selective CHIKV detection. A peak sensitivity of 800 nm∕RIU at N ¼ 4 is achieved by analyzing PC transmittance spectrum curves in the presence of diverse blood elements to emulate real-world conditions. Optimal average sensitivity at 1037.5 nm∕RIU is observed at incidence angles of 30 deg, 55 deg, and 80 deg, with 30 deg yielding the highest quality factor of 1015.94. This PC-based biosensor exhibits promise for compact, highly sensitive, and precise virus detection, potentially advancing viral detection biosensor technology and enhancing diagnostic tools for infectious diseases.

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Coinfection and circulation of chikungunya virus and dengue virus in pediatric patients in Myanmar, 2019

Cited by 6 publications

References 41 publications

Burden of Chikungunya Virus Infection during an Outbreak in Myanmar

Burden of Chikungunya Virus Infection during an Outbreak in Myanmar

Possible vertical transmission of Chikungunya virus infection detected in the cord blood samples from a birth cohort in Vietnam

Optimization of a ternary photonic crystal biosensor for enhanced chikungunya virus detection

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