Coinfection of a Bearded Dragon, <i>Pogona vitticeps</i>, with Adenovirus- and Dependovirus-like Viruses

Jacobson, Elliott R.; Kopit, W.; Kennedy, Frances A.; Funk, Richard S.

doi:10.1177/030098589603300313

Cited by 50 publications

(38 citation statements)

References 11 publications

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“…In addition to human and primates, AAV has also been isolated from different species including cow [Schmidt, M et al, 2004], chicken [Bossis. I and Chiorini, JA, 2003], sheep [Clarke, JK et al, 1979], snake [Farkas, SL et al, 2004], lizard [Jacobson, ER et al, 1996], and goat [Olson, EJ et al, 2004]. The isolation of new AAV serotypes from animal tissues and the development of these new variants into gene therapy vectors are discussed in a separate review in this issue [Gao et al].…”

Section: Isolation Of Aav Serotypes From Animal Tissues: Aav1 -11mentioning

confidence: 99%

AAV Hybrid Serotypes: Improved Vectors for Gene Delivery

Choi¹,

McCarty²,

Samulski³

2005

CGT

165

128

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In recent years, significant efforts have been made on studying and engineering adeno-associated virus (AAV) capsid, in order to increase efficiency in targeting specific cell types that are nonpermissive to wild type (wt) viruses and to improve efficacy in infecting only the cell type of interest. With our previous knowledge of the viral properties of the naturally occurring serotypes and the elucidation of their capsid structures, we can now generate capsid mutants, or hybrid serotypes, by various methods and strategies. In this review, we summarize the studies performed on AAV retargeting, and categorize the available hybrid serotypes to date, based on the type of modification: 1) transcapsidation, 2) adsorption of bi-specific antibody to capsid surface, 3) mosaic capsid, and 4) chimeric capsid. Not only these hybrid serotypes could achieve high efficiency of gene delivery to a specific targeted cell type, which can be better-tailored for a particular clinical application, but also serve as a tool for studying AAV biology such as receptor binding, trafficking and genome delivery into the nucleus. Keywords

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Section: Isolation Of Aav Serotypes From Animal Tissues: Aav1 -11mentioning

confidence: 99%

AAV Hybrid Serotypes: Improved Vectors for Gene Delivery

Choi¹,

McCarty²,

Samulski³

2005

CGT

165

128

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“…Initially, the presence of several RNA and DNA viruses in different reptilian hosts was diagnosed essentially on the basis of light or electron microscopic histology findings, and successful virus isolation has been limited to a few occasions only. By histology, parvovirus-like particles were observed and described in a bearded dragon (Pogona vitticeps) with concurrent adenovirus (AdV) infection (Jacobson et al, 1996). A similar double infection by adenovirus and dependovirus in California mountain kingsnakes (Lampropeltis zonata multicincta) has been published more recently (Wozniak et al, 2000).…”

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confidence: 83%

“…These viruses are capable of autonomous replication in spite of their genome organisation and phylogenetic place showing them clearly to belong to the Dependovirus genus (Le Gall-Reculé and Jestin, 1994;Brown et al, 1995;Zádori et al, 1995). Nonetheless, parvoviruses in reptiles have been found with concomitant adeno-or herpesvirus infection in all cases reported previously (Heldstab and Bestetti, 1984;Ahne and Scheinert, 1989;Jacobson et al, 1996;Wozniak et al, 2000;Kim et al, 2002;Farkas and Gál, 2008).…”

mentioning

confidence: 89%

Novel parvovirus from the worm lizard Trogonophis wiegmanni — First virus ever detected in amphisbaenian hosts

Pénzes

Benkő

2014

Acta Veterinaria Hungarica

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To explore the diversity of some DNA viruses in reptiles, a continuous screening is going on, in our laboratory, by PCR using different consensus primers designed for the detection of the most conserved genome regions of adeno-, herpes-and parvoviruses. The test material consists essentially of dead specimens collected randomly from private pet owners, local pet shops, or at occasional exotic pet fairs. Here we report the partial sequence of a putative novel parvovirus obtained from a dead checkerboard worm lizard (Trogonophis wiegmanni) that had been wild-caught in its native habitat. An in-house-developed PCR with consensus primers targeting the gene of the parvoviral capsid protein was used. Other PCRs, intended to detect certain large DNA viruses, remained negative. The sequence of the PCR product indicated the presence of a hitherto unknown parvovirus in the internal organs of the checkerboard worm lizard. In phylogeny reconstruction, the novel sequence clustered with the members of the Dependovirus genus of the Parvoririnae subfamily, closest to the branch of snake adenoassociated virus. Since we could not demonstrate the presence of a potential helper virus, the putative amphisbaenian parvovirus supposedly can replicate autonomously. This is the first virus infection ever detected in any members of the suborder Amphisbaenia, and only the third parvoviral sequence obtained from any reptilian host.

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“…AAV genomes have not been isolated only from primates, but also from other species such as horse (Dutta, 1975), lizard (Jacobson et al, 1996), chicken (Bossis and Chiorini, 2003), cow (Schmidt et al, 2004), snake (Farkas et al, 2004) and goat (Olson et al, 2004;Arbetman et al, 2005). Among these, AAV isolates from bovine, avian and caprine species have been developed into vectors for gene transfer studies (Schmidt et al, 2004;Bossis and Chiorini, 2003;Arbetman et al, 2005).…”

Section: Adeno-associated Virus Serotypesmentioning

confidence: 99%

A role for adeno-associated viral vectors in gene therapy

Coura

Nardi

2008

Genet. Mol. Biol.

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Gene therapy constitutes a therapeutic intervention based on modification of the genetic material of living cells, by correcting genetic defects or overexpressing therapeutic proteins. The success of gene therapy protocols depends on the availability of therapeutically suitable genes, appropriate gene delivery systems and proof of safety and efficacy. Recent advances on the development of gene delivery systems, particularly on viral vectors engineering and improved gene regulatory systems, have led to marked progress in this field. Although the available vector systems can successfully transfer genes into cells, the ideal delivery vehicle has not been found. In this context, adeno-associated virus vectors (AAV) are arising as a promising tool for a wide range of applications, due to a combination of characteristics such as lack of pathogenicity and immunogenicity, wide range of cell tropism and long-term gene expression. Since its isolation, the biological properties of the adeno-associated virus have been increasingly understood, improving our ability to manipulate and use it as a safe and efficient gene therapy vector of wide spectrum. In this work, we review the bases of gene therapy, main types of gene transfer systems and basic properties and use of AAV vectors.

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Coinfection of a Bearded Dragon, Pogona vitticeps, with Adenovirus- and Dependovirus-like Viruses

Cited by 50 publications

References 11 publications

AAV Hybrid Serotypes: Improved Vectors for Gene Delivery

AAV Hybrid Serotypes: Improved Vectors for Gene Delivery

Novel parvovirus from the worm lizard Trogonophis wiegmanni — First virus ever detected in amphisbaenian hosts

A role for adeno-associated viral vectors in gene therapy

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