Coinfection of Parvovirus B19 With Other Hepatitis Viruses Leading to Fulminant Hepatitis of Unfavorable Outcome in Children

Dwivedi, Manish Kumar; Manocha, Harmesh; Tiwari, Soumya; Tripathi, Gaurav; Tn, Dhole

doi:10.1097/inf.0b013e318198d05c

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…Dwivedi et al in their study of 48 patients with FHF, divided them into three groups as those associated with (i) B19 infection alone, (ii) one or more other hepatotropic viral infection in the absence of B19 infection, and (iii) B19 coinfection with other hepatotropic viruses. They found that FHF caused by B19 and coinfection with other hepatitis viruses had severe jaundice, high bilirubin, high alanine aminotransferase or aspartate aminotransferase activity, and unfavorable outcome resulting in death of most of these patients, compared with those with isolated B19 or other hepatitis viruses infection [56]. It was hypothesized that B19 possibly may cause injury to hepatocytes independently or by producing synergistic effect when present along with other hepatitis viruses.…”

Section: Parvovirus B19 and Hepatitismentioning

confidence: 99%

Parvovirus B19 Associated Hepatitis

Bihari

Rastogi

Saxena

et al. 2013

Hepatitis Research and Treatment

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Parvovirus B19 infection can present with myriads of clinical diseases and syndromes; liver manifestations and hepatitis are examples of them. Parvovirus B19 hepatitis associated aplastic anemia and its coinfection with other hepatotropic viruses are relatively underrecognized, and there is sufficient evidence in the literature suggesting that B19 infections can cause a spectrum of liver diseases from elevation of transaminases to acute hepatitis to fulminant liver failure and even chronic hepatitis. It can also cause fatal macrophage activation syndrome and fibrosing cholestatic hepatitis. Parvovirus B19 is an erythrovirus that can only be replicate in pronormoblasts and hepatocytes, and other cells which have globosides and glycosphingolipids in their membrane can also be affected by direct virus injury due to nonstructural protein 1 persistence and indirectly by immune mediated injury. The virus infection is suspected in bone marrow aspiration in cases with sudden drop of hemoglobin and onset of transient aplastic anemia in immunosuppressed or immunocompetent patients and is confirmed either by IgM and IgG positive serology, PCR analysis, and in situ hybridization in biopsy specimens or by application of both. There is no specific treatment for parvovirus B19 related liver diseases, but triple therapy regimen may be effective consisting of immunoglobulin, dehydrohydrocortisone, and cyclosporine.

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Section: Parvovirus B19 and Hepatitismentioning

confidence: 99%

Parvovirus B19 Associated Hepatitis

Bihari

Rastogi

Saxena

et al. 2013

Hepatitis Research and Treatment

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“…An increasing spectrum of clinical manifestation of B19V infection has been described ( Bathla et al 2014 ), including hepatitis, which is commonly caused by hepatotropic viruses (A-E) ( Hatakka et al 2011 , Rauff et al 2011 , Huang et al 2012 ). On the basis of its DNA detection in the liver of patients with acute liver failure (ALF) associated with BM aplasia and in the serum of patients with ALF of unknown aetiology, B19V has been implicated as an aetiological agent for ALF-associated aplastic anaemia ( Aoyagi et al 1987 , Langnas et al 1995 , Bernuau et al 1999 , Abe et al 2007 , Dwivedi et al 2009 , Huang et al 2012 , Bathla et al 2014 ).…”

mentioning

confidence: 99%

“…ALF is a severe complication of acute viral hepatitis, which occurs in less than 1% of the cases and is generally caused by hepatitis A-E viruses either single or in combinations ( Dwivedi et al 2009 ). However, previous reports have demonstrated a hepatic severity significantly greater in patients with hepatotropic viruses (A and E) co-infected with B19V ( Ozcay et al 2006 , Kishore & Sen 2009 ).…”

mentioning

confidence: 99%

“…However, previous reports have demonstrated a hepatic severity significantly greater in patients with hepatotropic viruses (A and E) co-infected with B19V ( Ozcay et al 2006 , Kishore & Sen 2009 ). Recently, one study carried out with 48 paediatric patients with ALF showed the presence of the B19V genome in 19 (39%) cases, of which 13 (27%) were also positive for IgM antibodies against other hepatitis viruses ( Dwivedi et al 2009) . Comparing the clinical characteristics and outcomes of patients having liver failure associated with B19V alone and co-infected with hepatitis A, B, C or E, the results showed that the disease was significantly more severe in patients with B19V co-infection.…”

mentioning

confidence: 99%

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Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A virus: no evidence of the co-infection as a cause of acute liver failure

Leon

Marchevsky

Gaspar

et al. 2016

Mem. Inst. Oswaldo Cruz

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This study was conducted to analyse the course and the outcome of the liver disease in the co-infected animals in order to evaluate a possible synergic effect of human parvovirus B19 (B19V) and hepatitis A virus (HAV) co-infection. Nine adult cynomolgus monkeys were inoculated with serum obtained from a fatal case of B19V infection and/or a faecal suspension of acute HAV. The presence of specific antibodies to HAV and B19V, liver enzyme levels, viraemia, haematological changes, and necroinflammatory liver lesions were used for monitoring the infections. Seroconversion was confirmed in all infected groups. A similar pattern of B19V infection to human disease was observed, which was characterised by high and persistent viraemia in association with reticulocytopenia and mild to moderate anaemia during the period of investigation (59 days). Additionally, the intranuclear inclusion bodies were observed in pro-erythroblast cell from an infected cynomolgus and B19V Ag in hepatocytes. The erythroid hypoplasia and decrease in lymphocyte counts were more evident in the co-infected group. The present results demonstrated, for the first time, the susceptibility of cynomolgus to B19V infection, but it did not show a worsening of liver histopathology in the co-infected group.

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Viral Causes of Acute Liver Failure in Children

Squires

2019

Viral Hepatitis in Children

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Coinfection of Parvovirus B19 With Other Hepatitis Viruses Leading to Fulminant Hepatitis of Unfavorable Outcome in Children

Cited by 12 publications

References 8 publications

Parvovirus B19 Associated Hepatitis

Parvovirus B19 Associated Hepatitis

Cynomolgus monkeys (Macaca fascicularis) experimentally infected with B19V and hepatitis A virus: no evidence of the co-infection as a cause of acute liver failure

Viral Causes of Acute Liver Failure in Children

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